In the Circulation Research article by Sequeira et al (Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations. Circ Res. 2013;112:1491–1505) the authors recently discovered that one mutant sample in the study was mistakenly identified. In specific, the mutant sample (TPM1mut) that encodes a mutation in the gene of tropomyosin (TPM1) has been previously identified as M281T (a methionine was mutated to threonine at residue 281). However, liquid chromatography-mass spectrometry with peptide mass fingerprinting (LC-MS/MS) data has revealed that the mutation in the TPM1mut sample is consistent with I284V (isoleucine residue is mutated into a valine). This means that the mutation occurred on residue 284 (the last amino acid residue of tropomyosin), and not residue 281.
The specific alteration of the TPM1mut sample identification to I284V will not change, in any form, the message of the paper, and importantly will not affect the discussion and findings that concern the TPM1mut sample.
The authors apologize for this error, and the error has been noted in the online version of the article, which is available at http://circres.ahajournals.org/content/112/11/1491.full.
- © 2013 American Heart Association, Inc.