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Editorial

Creatine—A Dispensable Metabolite?

Heinrich Taegtmeyer, Joanne S. Ingwall
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https://doi.org/10.1161/CIRCRESAHA.113.300974
Circulation Research. 2013;112:878-880
Originally published March 14, 2013
Heinrich Taegtmeyer
From the Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School, Houston, TX (H.T.); and Department of Medicine (Physiology), Harvard Medical School, Boston, MA (J.S.I.).
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Joanne S. Ingwall
From the Department of Internal Medicine, Division of Cardiology, The University of Texas Medical School, Houston, TX (H.T.); and Department of Medicine (Physiology), Harvard Medical School, Boston, MA (J.S.I.).
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  • creatine
  • creatinine
  • creatine kinase
  • phospho creatine
  • muscle
  • energy transfer

Ask any medical student for a definition of the terms creatinine or creatine kinase (CK), and he or she will come up with a precise answer. Ask the same person for a definition of creatine, and the answer will be less precise. In general terms, creatine is regarded as a muscle energizer, and in medical terms creatine is considered as the mother substance for both phosphocreatine (PCr) and creatinine (Figure). But what is creatine? Creatine is a nitrogenous organic acid, derived from glycine, l-arginine and S-adenosyl-l-methionine which is involved in energy transfer in the form of PCr and which is metabolized to creatinine to be excreted by the kidney. The bulk of creatine is stored in muscle, hence creatine’s name, derived from the Greek word for flesh (τό κϱέας). The mammalian body derives about half of its creatine stores from meat sources in food; the other half is made in the kidney and liver (Figure). The first enzyme in the pathway is l-arginine:glycine amidino transferase. The second enzyme in the pathway of creatine synthesis is arginine-glycine aminotransferase.1 Creatine (or β-methyl guanidoacetic acid, a β-amino acid) is nonenzymatically converted to creatinine. Up until now, creatine has been considered essential for muscle energetics and function.

Article, see p 945

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Figure.

The central role of creatine as substrate for the creatine kinase reaction and as substrate for the nonenzymatic conversion to creatinine. AGAT indicates l-arginine:glycine amidinotransferase (E.C.2.1.4.1); GAMT, G-Adenosyl-L-methionine:N-guanidino-methyltransferase (E.C.2.1.1.2); CrT, creatine transporter; CK, creatine kinase; PCr, phospho creatine; SAM, S-adenosyl-L-methionine; and SAH, S-adenosyl homecysteine. Not shown in the figure are the pleotropic functions of creatine, including creatine's role in amino acid metabolism and isoforms of CK (see text).

Cardiovascular scientists have long regarded creatine as an essential metabolite in the network of energy transfer.2,3 Indeed, the evidence for creatine and PCr as intermediaries of energy transfer is compelling and supported by a large body of literature.4–6 Over the years countless studies have described the multifaceted roles of PCr and the CK system. Loss of CK in heart or skeletal muscle results in contractile dysfunction. Classical experimental studies have included tissue-specific expression and subcellular location of CK isoforms, high-resolution molecular structure–function relationships, and deletion of CK isoforms.5 The CK/PCr system is both a buffer and a shuttle for energy-rich phosphates between the sites of ATP use and production, and the molecular and cellular basis for the cardioprotective action of PCr is well established.7 Not surprisingly, there is also wide ranging evidence for the beneficial effects of creatine supplementation, especially in the elderly,8 and in patients with muscle wasting disease.9 But even more importantly, the PCr system has long been regarded essential for energy transfer in muscle.

The authors of the paper by Lygate et al10 published in this issue are among the many who have contributed to this scenario, but they now challenge the concept of an essential role for creatine.

Using a combined genetic and dietary model of creatine deficiency in mice. Lygate et al10 observed no impairment in maximal exercise capacity, no changes in the response to chronic myocardial infarction, and no evidence for metabolic adaptations. In short, based on a lack of a phenotype, the workers question whether creatine is essential to support either high workload or chronic stress responses in heart and skeletal muscle. Does this mean that creatine (and with it, the CK system) is a dispensable molecule like there are dispensable α−amino acids?11 Are creatine and PCr perhaps akin to wisdom teeth in our mouth (ie, useful but atavistic)? The answer is "Probably not."

Low levels of creatine and PCr, and of CK and creatine transporter activities are all well-documented features of failing hearts.2,3,12–16 The evidence, deduced first from measurements of creatine levels and CK activity in failing mammalian hearts and subsequently from chemical inhibitors and genetic models, seems to support a causal relation between low creatine and PCr levels and heart failure. However, doubters may raise the question whether disturbances in creatine metabolism are cause or consequence of heart failure. The new results reported by Lygate et al10 seem to challenge the concept that low creatine concentrations in heart muscle mediate impaired contractile function of failing heart muscle (as has been proposed), or that low creatine transporter levels or low CK activity are mediators of maladaptive responses to hemodynamic and neurohumonal stresses. The data also cast doubt on the usefulness of creatine as a performance-enhancing drug in athletes, or as a drug for the treatment of cachexia and the pleiotropic effects of creatine, including adenine nucleotide metabolism, cardioprotection, and promotion of protein synthesis.5

One question to ask is "Why has evolutionary pressure put creatine into the system of cells with high rates of energy turnover (heart, brain, and skeletal muscle)"? According to Brosnan et al,17 creatine synthesis consumes 20% to 30% of arginine’s amidino groups, regardless of whether provided in the diet or synthesized by the body. Creatine synthesis is indeed a major pathway in amino acid metabolism, especially metabolism of arginine and methionine. Hence, there is an undisputed role for creatine in amino acid and nitrogen metabolism. There is also a role for creatine in protection of the ischemic, reperfused myocardium as the authors of the present study have recently shown.18

Are we looking for the key under the lamp post? Several issues come to mind. First, the creatine/PCr system is only one part of the complex and highly regulated system of enzyme catalyzed reactions involved in energy transfer in living tissues.19 Just like the stock market reflects the economy, it is not the economy itself. Second, only very few of us have considered the problem of how signal transduction events in heart (or any other tissue) are connected to cellular metabolism.20 We probably still do not know enough, and all the hard work of the brightest investigators is still not immune from the IKEA effect (a term used by economists to denote the increase in valuation of one’s own work).21 Third, and in spite of what has just been said, CK-catalyzed phosphotransfer is undoubtedly a major component of the energy-rich phosphate transfer coupling, ATP production in mitochondria to sites of ATP hydrolysis.22

The big enigma is why the loss of substrate for the CK reaction is tolerated by the mouse hearts, whereas loss of the enzyme CK is not. Both should be physiologically equivalent. The central issue here is whether the adaptive responses to the loss of CK may also exist hearts with no creatine. Deletion of CK induces a shift in substrate utilization networks by redirecting phosphotransfer flux through alternative adenylate kinase,23 glycolytic and guanine nucleotide systems.22,24 The present study may not have captured these adaptations. First, the authors have focused on the proteome of Cr-deficient mouse hearts at baseline and did not assess whether there are differences in the proteome during heart failure. Given that there were little or no changes in the activities of possible compensatory phosphotransfer enzymes in CK-deficient mouse hearts, it is not surprising to see no changes in the proteome of normal creatine-deficient mouse hearts. Second, some critical measurements yet to be made are flux through other phosphotransfer pathways and the assessment of changes in the metabolomic profile. Third, as pointed out by the authors, no information is available on any differences in post-translational modifications. Fourth, although the comprehensive in vivo characterization of the creatine-deficient model includes increased hemodynamic loads in response to exercise and myocardial infarction, an acute increase in workload is probably the best way to expose the function of PCr as an intracellular buffer for ATP.25 This was not attempted. Lastly, echoing the recent article suggesting that mice may not be a good model for human diseases,26 the mismatch in genotype–phenotype for the CK system in the mouse compared with large mammals, including man, suggests that the mouse may be an interesting anomaly. In short, the reasons why Cr-deficient mouse hearts do not demonstrate the phenotype observed for CK-deficient mouse hearts by many investigators, including these authors, remain undefined.

The study by Lygate et al10 thus exposes a new facet of the complexity of energy transfer in the heart. It is not the end, but only the beginning of further investigations into the burning question whether energy starvation of the failing heart4 is cause or consequence of contractile dysfunction. The metabolic derangements in the failing heart are now being assessed by a wide array of tools ranging from metabolomic to proteomic and transcriptionic analyses. They are at least as complex as the system of energy transfer itself.27 The paper by Lygate et al.10 heightens our awareness that the study of metabolic regulation in heart and skeletal muscle can still yield big surprises.

Acknowledgments

We thank Roxy A. Tate for expert editorial assistance, and Truong Lam for the illustration.

Sources of Funding

We are grateful for funding support by the National Heart, Lung, and Blood Institute: 5R01HL073162 and 5R01HL061483 (Heinrich Taegtmeyer).

Disclosures

None.

Footnotes

  • The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.

  • © 2013 American Heart Association, Inc.

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    Creatine—A Dispensable Metabolite?
    Heinrich Taegtmeyer and Joanne S. Ingwall
    Circulation Research. 2013;112:878-880, originally published March 14, 2013
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    Creatine—A Dispensable Metabolite?
    Heinrich Taegtmeyer and Joanne S. Ingwall
    Circulation Research. 2013;112:878-880, originally published March 14, 2013
    https://doi.org/10.1161/CIRCRESAHA.113.300974
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