Notice of Retraction

The American Heart Association (AHA) published an expression of concern^1–3 simultaneously in Circulation, Circulation Research, and Hypertension, and we have now been notified by Kyoto Prefectural University of Medicine that certain data and figures in these 5 articles were falsified. Kyoto Prefectural University of Medicine sends their deepest apologies to the academic community at large.

The AHA is hereby retracting these articles:

Fujiyama S, Matsubara H, Nozawa Y, Maruyama K, Mori Y, Tsutsumi Y, Masaki H, Uchiyama Y, Koyama Y, Nose A, Iba O, Tateishi E, Ogata N, Jyo N, Higashiyama S, Iwasaka T. Angiotensin AT₁ and AT₂ receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding–epidermal growth factor (EGF)–mediated EGF receptor transactivation. Circ Res. 2001;88:22-29. doi:10.1161/01.RES.88.1.22.

Shibasaki Y, Matsubara H, Nozawa Y, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T. Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase. Hypertension. 2001;38:367-372. doi:10.1161/01.HYP.38.3.367.

Iba O, Matsubara H, Nozawa Y, Fujiyama S, Amano K, Mori Y, Kojima H, Iwasaka T. Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs. Circulation. 2002;106:2019-2025. doi:10.1161/01.CIR.0000031332.45480.79.

Amano K, Matsubara H, Iba O, Okigaki M, Fujiyama S, Imada T, Kojima H, Nozawa Y, Kawashima S, Yokoyama M, Iwasaka T. Enhancement of ischemia-induced angiogenesis by eNOS overexpression. Hypertension. 2003;41:156-162. doi:10.1161/01.HYP.0000053552.86367.12.

Mano A, Tatsumi T, Shiraishi J, Keira N, Nomura T, Takeda M, Nishikawa S, Yamanaka S, Matoba S, Kobara M, Tanaka H, Shirayama T, Takamatsu T, Nozawa Y, Matsubara H. Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways. Circulation. 2004;110:317-323. doi:10.1161/01.CIR.0000135599.33787.CA.

• © 2013 American Heart Association, Inc.