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Pim-1 and Chromatid Segregation (p 1169)
Sundararaman et al report that asymmetry is best when it comes to progenitor cell chromatid division, and Pim-1 can help.
Stem cells do not divvy up their chromatids randomly at cell division. After DNA replication, sister chromatids are selectively distributed to daughter cells, though whether this is due to 1 cell always retaining the template strands—the immortal strand hypothesis—or is dependent on epigenetic differences between chromatids—the silent sister hypothesis—is not clear. Whatever the precise mechanism, this asymmetric chromatid division is thought to be essential for stem cell self-renewal. That is, the ability of stem cells to give rise not only to daughter cells that differentiate, but also to replacement stem cells. It is thought that boosting the ability of …