Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
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atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and collateral formation, stroke, and heart failure. In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development.
- NADPH oxidases
- vascular smooth muscle
- endothelial cells
- cardiac hypertrophy
- cardiovascular disease
- reactive oxygen species
- Received December 22, 2011.
- Revision received February 9, 2012.
- Accepted March 9, 2012.
- © 2012 American Heart Association, Inc.