Protective Role for Myeloid Specific KLF2 in Atherosclerosis
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In this issue of Circulation Research, Lingrel and colleagues1 describe the phenotype of myeloid-specific Klf2 knockout mice. Although this transcription factor has long been known to be involved in protection from atherosclerosis, the cell type responsible was not clear.
Article, see p 1294
Chronic inflammatory diseases, such as atherosclerosis, are associated with imbalanced recruitment of monocytes and neutrophils to the impaired tissue. Neutrophils are among the first cells detected in developing atherosclerotic plaque. As early as in fatty streaks, monocytes enter the nascent lesions and can differentiate into macrophages.2 Lineage and microenvironmental stimuli determine the macrophages' phenotypic and biological functions, with proinflammatory …