Left Atrial Pressure Curve as an Index of Control of Fluid Volume
The concept that the left atrial pressure or pulse pressure acts as a stimulus to receptors for control of fluid volume was tested by examining the data on 67 persons who underwent right and left heart catheterization. Although there is no direct relationship between left atrial pulse pressure and congestive heart failure, no patient in failure had a pulse pressure below normal. Furthermore, those with the more severe grade of failure had the highest left atrial pulse pressure and the more rapid ascent of the left atrial pressure curve. These findings are inconsistent with the concept that a diminished left atrial pressure or pulse pressure stimulates left atrial receptors to set in motion a train of events which provoke antidiuresis in congestive heart failure. On the other hand, if increased left atrial pressure or pulse pressure promotes diuresis, the mechanism is completely overridden by more potent factors in human congestive heart failure.
- Received March 8, 1962.
- © 1962 American Heart Association, Inc.