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Poster Session 1Session Title: Cardiac Regeneration, Stem Cells and Tissue Engineering

Abstract P022: Functional and Transcriptomic Recovery of Infarcted Mouse Myocardium Treated with Bone Marrow Mononuclear Cells

Adriana B Carvalho, Stephan Lachtermacher, Bruno Esporcatte, Nazareth Rocha, Patricia Costa, Dumitru Iacobas, Sanda Iacobas, David C Spray, Regina Goldenberg, Antonio Carlos Campos de Carvalho
Circulation Research. 2011;109:AP022
Adriana B Carvalho
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Stephan Lachtermacher
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Bruno Esporcatte
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Nazareth Rocha
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Patricia Costa
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Dumitru Iacobas
Albert Einstein College of Medicine, New York, NY
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Sanda Iacobas
Albert Einstein College of Medicine, New York, NY
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David C Spray
Albert Einstein College of Medicine, New York, NY
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Regina Goldenberg
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Antonio Carlos Campos de Carvalho
Federal Univ of Rio de Janeiro, Rio de Janeiro, Brazil
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Abstract

Although bone marrow-derived mononuclear cells (BMNC) have been extensively used in cell therapy for cardiac diseases, little mechanistic information is available to support reports of their efficacy. To address this shortcoming, we compared structural and functional recovery and associated global gene expression profiles in post-ischaemic myocardium treated with BMNC transplantation. BMNC suspensions were injected into cardiac scar tissue ten days after experimental myocardial infarction. Six weeks later, mice undergoing BMNC therapy were found to have normalized antibody repertoire and improved cardiac performance measured by ECG, treadmill exercise time and echocardiography. After functional testing, gene expression profiles in cardiac tissue were evaluated using high-density oligonucleotide arrays. Expression of more than 18% of the 11981 quantified unigenes was significantly altered in the infarcted hearts. BMNC therapy restored expression of 2099 (96.2%) of the genes that were altered by infarction but led to altered expression of 286 new genes, considered to be a side effect of the treatment. Transcriptional therapeutic efficacy, a new metric calculated using a formula that incorporates both recovery and side effect of treatment, was 74.5%. In conclusion, our results confirm a beneficial role for bone marrow-derived cell therapy and provide new information on molecular mechanisms operating after BMNC transplantation on post ischemic heart failure in mice.

  • Stem/progenitor cells
  • Myocardial infarction, STEMI
  • Gene expression
  • © 2011 by American Heart Association, Inc.
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Circulation Research
9 December 2011, Volume 109, Issue Suppl 1
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    Abstract P022: Functional and Transcriptomic Recovery of Infarcted Mouse Myocardium Treated with Bone Marrow Mononuclear Cells
    Adriana B Carvalho, Stephan Lachtermacher, Bruno Esporcatte, Nazareth Rocha, Patricia Costa, Dumitru Iacobas, Sanda Iacobas, David C Spray, Regina Goldenberg and Antonio Carlos Campos de Carvalho
    Circulation Research. 2011;109:AP022, originally published October 8, 2015

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    Abstract P022: Functional and Transcriptomic Recovery of Infarcted Mouse Myocardium Treated with Bone Marrow Mononuclear Cells
    Adriana B Carvalho, Stephan Lachtermacher, Bruno Esporcatte, Nazareth Rocha, Patricia Costa, Dumitru Iacobas, Sanda Iacobas, David C Spray, Regina Goldenberg and Antonio Carlos Campos de Carvalho
    Circulation Research. 2011;109:AP022, originally published October 8, 2015
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