A, Nanotechnology publications citing National Heart, Lung, and Blood Institute (NHLBI) funding (dark gray) and NHLBI Programs of Excellence in Nanotechnology (PEN)-supported publications (light gray). B, Citations of NHLBI-funded nanotechnology publications. Data were obtained using the Electronic Scientific Portfolio Assistant (eSPA).28
A, Gradient echo (GRE) and positive contrast (GRASP) MRIs obtained before (PR) and after (POST) administration of lipid-coated ultrasmall iron oxide particles (LUSPIO) in apoE+/+ mice. Yellow arrows indicate the lumen of the abdominal aorta. LUSPIO uptake appears as white on the positive contrast GRASP images. Matched histology sections show iron deposition (blue) within foam cells associated with the arterial wall. B, Quantification of changes in MR signal after administration of targeted and nontargeted LUSPIO. From Briley-Saebo et al,8 with permission from Elsevier.
A, Microcomputed tomography angiograms of hind limbs of mice subjected to femoral artery ligation and treated with vascular endothelial growth factor (VEGF) nanoparticles (VEGF-NP), VEGF 5 μg (V 5 μg), VEGF 2.5 μg (V 2.5 μg), or saline for 4 days. D0 animals were prepared for micro-CT immediately after surgery; nonsurgery animals were not subjected to ligation. B, Total vessel volume in the ligated limb compared with the nonligated limb. From Golub et al,11 with permission from the National Academy of Sciences.