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Role of Tryptase in Abdominal Aortic Aneurysm (p 1316)
Zhang et al reveal tryptase as a mast cell mediator of aortic aneurysm.
Abdominal aortic aneurysms (AAAs) that develop because of the expansion of the artery like a balloon can be life-threatening in the event of rupture. The hope is that AAAs can be caught early and surgically repaired. Zhang et al have now found that in patients with AAA, serum tryptase levels correlate with expansion and pose a risk for later surgical repair and mortality. This suggests that tryptase might serve as a useful biomarker for AAA development. The team also showed that high levels of serum tryptase were a result of an increase in mast cells, previously …