EFFECT OF RATE OF GROWTH
Young, rapidly growing rabbits developed more aortic atherosclerosis on an ad libitum cholesterol-containing diet than did older, more slowly growing rabbits. This effect may be due to an affinity of newly formed tissue, produced during growth, for lipids; this may be a partial explanation of the increase in the number of fatty streaks seen around the age of puberty in humans. A possible mechanism, based on local aortic injury, is presented to account for the localization and development of human atherosclerotic lesions.
- Received December 8, 1961.
- © 1962 American Heart Association, Inc.