Peripheral Vasoconstriction Associated with Hyperpotassemia
Hyperpotassemia was induced in hamsters by intravenous infusions of potassium salts. The caliber of blood vessels (10 to 100µ in diameter) in the cheek pouch was measured and comparisons were made when serum potassium concentration was maintained at 9.0 (σ= ± 1.64 mEq./L.) for 10 to 14 minutes and again at 12.3 (σ= ± 1.14 mEq./L.) for 10 to 14 minutes. In unoperated controls, a significant degree of vasoconstriction occurred in all arterial vessels at both levels of hyperpotassemia. Venular constriction was found at the higher potassium concentrations. Sympathetic denervation of the blood vessels had no effect on the vasoconstrictor response. Adrenalectomy prevented vasoconstriction at a potassium level of 9.0 mEq./L., but vasoconstriction was still evident in small arterioles at higher potassium levels. Sympathetic denervation of blood vessels in adrenalectomized animals, or treatment of intact animals with Dibenzylene, prevented vasoconstriction produced by hyperpotassemia. These data indicate that peripheral vasocontriction associated with hyperpotassemia is an indirect effect of the potassium ion.
- Received October 6, 1961.
- © 1962 American Heart Association, Inc.