Mechanism of the Myocardial Effects of Bretylium
The increased myocardial contractility resulting from the injection of bretylium has been shown to be accompanied by a myocardial release of catecholamines. Cardiac sympathetic nerve stimulation following bretylium is associated with neither an increased contractility nor a release of myocardial catecholamines. The failure to release catecholamines under these conditions does not result from depletion, but rather from a block of the nerve release mechanism.
- Received September 25, 1961.
- © 1962 American Heart Association, Inc.