Metabolism

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Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol ProductionNovelty and Significance
Manon Viaud, Stoyan Ivanov, Nemanja Vujic, Madalina Duta-Mare, Lazaro-Emilio Aira, Thibault Barouillet, Elsa Garcia, Francois Orange, Isabelle Dugail, Isabelle Hainault, Christian Stehlik, Sandrine Marchetti, Laurent Boyer, Rodolphe Guinamard, Fabienne Foufelle, Andrea Bochem, Kees G. Hovingh, Edward B. Thorp, Emmanuel L. Gautier, Dagmar Kratky, Paul Dasilva-Jardine and Laurent Yvan-Charvet

Circulation Research. 2018;122:1369-1384, originally published March 9, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312333

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Calcium Signaling and Reactive Oxygen Species in Mitochondria
Edoardo Bertero and Christoph Maack

Circulation Research. 2018;122:1460-1478, originally published May 10, 2018
https://doi.org/10.1161/CIRCRESAHA.118.310082

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The Vasculature in Prediabetes
David H. Wasserman, Thomas J. Wang and Nancy J. Brown

Circulation Research. 2018;122:1135-1150, originally published April 12, 2018
https://doi.org/10.1161/CIRCRESAHA.118.311912

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Enhanced Redox State and Efficiency of Glucose Oxidation With miR Based Suppression of Maladaptive NADPH-Dependent Malic Enzyme 1 Expression in Hypertrophied HeartsNovelty and Significance
Ryan Lahey, Andrew N. Carley, Xuerong Wang, Carley E. Glass, Kevin D. Accola, Scott Silvestry, J. Michael O’Donnell and E. Douglas Lewandowski

Circulation Research. 2018;122:836-845, originally published January 31, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312660

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Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial NetworkNovelty and Significance
Valentina Parra, Francisco Altamirano, Carolina P. Hernández-Fuentes, Dan Tong, Victoriia Kyrychenko, David Rotter, Zully Pedrozo, Joseph A. Hill, Verónica Eisner, Sergio Lavandero, Jay W. Schneider and Beverly A. Rothermel

Circulation Research. 2018;122:e20-e33, originally published January 23, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311522

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Mutations in CYB561 Causing a Novel Orthostatic Hypotension SyndromeNovelty and Significance
Maarten P. van den Berg, Rowida Almomani, Italo Biaggioni, Martijn van Faassen, Pim van der Harst, Herman H.W. Silljé, Irene Mateo Leach, Marc H. Hemmelder, Gerjan Navis, Gert Jan Luijckx, Arjan P.M. de Brouwer, Hanka Venselaar, Marcel M. Verbeek, Paul A. van der Zwaag, Jan D.H. Jongbloed, J. Peter van Tintelen, Ron A. Wevers and Ido P. Kema

Circulation Research. 2018;122:846-854, originally published January 17, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311949

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Steven J. Forrester, Daniel S. Kikuchi, Marina S. Hernandes, Qian Xu and Kathy K. Griendling

Circulation Research. 2018;122:877-902, originally published March 15, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311401

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E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor CellsNovelty and Significance
Shiyue Xu, Jun Tao, Liu Yang, Eric Zhang, Chan Boriboun, Junlan Zhou, Tianjiao Sun, Min Cheng, Kai Huang, Jiawei Shi, Nianguo Dong, Qinghua Liu, Ting C. Zhao, Hongyu Qiu, Robert A. Harris, Navdeep S. Chandel, Douglas W. Losordo and Gangjian Qin

Circulation Research. 2018;122:701-711, originally published January 22, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311814

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Revisiting Old FriendsSortilin-1, Low-Density Lipoprotein Receptor, and Prorenin Receptor as Modulators of Lipoprotein and Energy Metabolism
Alanna Strong

Circulation Research. 2018;122:652-654, originally published March 1, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312656

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(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and HepatosteatosisNovelty and Significance
Liwei Ren, Yuan Sun, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun, Noam Zelcer, Adam E. Mullick, A.H. Jan Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan and Xifeng Lu

Circulation Research. 2018;122:730-741, originally published January 4, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312422

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