Basic Science Research

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Heme Oxygenase-1 in Macrophages Drives Septic Cardiac Dysfunction via Suppressing Lysosomal Degradation of Inducible Nitric Oxide Synthase
Liangliang Jia, Yaping Wang, Yidong Wang, Yuankun Ma, Jian Shen, Zurong Fu, Yue Wu, Sheng'an Su, Yuhao Zhang, Zhejun Cai, Jian'an Wang and Meixiang Xiang

Circulation Research. 2018;CIRCRESAHA.118.312910, originally published April 18, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312910

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Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast ActivationNovelty and Significance
Ying-Chun Shih, Chao-Ling Chen, Yan Zhang, Rebecca L. Mellor, Evelyn M. Kanter, Yun Fang, Hua-Chi Wang, Chen-Ting Hung, Jing-Yi Nong, Hui-Ju Chen, Tzu-Han Lee, Yi-Shuan Tseng, Chiung-Nien Chen, Chau-Chung Wu, Shuei-Liong Lin, Kathryn A. Yamada, Jeanne M. Nerbonne and Kai-Chien Yang

Circulation Research. 2018;122:1052-1068, originally published March 13, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312130

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S1P–S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial InfarctionNovelty and Significance
Yoshihisa Yamada, Shohei Wakao, Yoshihiro Kushida, Shingo Minatoguchi, Atsushi Mikami, Kenshi Higashi, Shinya Baba, Taeko Shigemoto, Yasumasa Kuroda, Hiromitsu Kanamori, Mohamad Amin, Masanori Kawasaki, Kazuhiko Nishigaki, Masato Taoka, Toshiaki Isobe, Chisako Muramatsu, Mari Dezawa and Shinya Minatoguchi

Circulation Research. 2018;122:1069-1083, originally published February 23, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311648

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Critical Evaluation of Data Requires Rigorous but Broadly Based Statistical InferenceResponse by Lem Moyé and Michelle Cohen
Nancy J. Cox and Jennifer E. Below

Circulation Research. 2018;122:1049-1051, originally published April 12, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312530

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Cardiac c-Kit Biology Revealed by Inducible Transgenesis
Natalie A Gude, Fareheh Firouzi, Kathleen M Broughton, Kelli Ilves, Kristine P Nguyen, Christina R Payne, Veronica Sacchi, Megan M Monsanto, Alexandria R Casillas, Farid G Khalafalla, Bingyan J Wang, David Ebeid, Roberto Alvarez, Walter P Dembitsky, Barbara A Bailey, Jop H van Berlo and Mark A Sussman

Circulation Research. 2018;CIRCRESAHA.117.311828, originally published April 10, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311828

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Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult HeartNovelty and Significance
Juan Tang, Hui Zhang, Lingjuan He, Xiuzhen Huang, Yan Li, Wenjuan Pu, Wei Yu, Libo Zhang, Dongqing Cai, Kathy O. Lui and Bin Zhou

Circulation Research. 2018;122:984-993, originally published January 26, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312354

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Specific Activation of the Alternative Cardiac Promoter of Cacna1c by the Mineralocorticoid ReceptorNovelty and Significance
Thassio R. Mesquita, Gaëlle Auguste, Débora Falcón, Gema Ruiz-Hurtado, Rogelio Salazar-Enciso, Jessica Sabourin, Florence Lefebvre, Say Viengchareun, Hussein Kobeissy, Patrick Lechène, Valérie Nicolas, Amaya Fernandez-Celis, Susana Gómez, Sandra Lauton Santos, Eric Morel, Angelica Rueda, Natalia López-Andrés, Ana Maria Gómez, Marc Lombès and Jean-Pierre Benitah

Circulation Research. 2018;122:e49-e61, originally published February 21, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312451

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Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction
Xavier Loyer, Ivana Zlatanova, Cécile Devue, Min Yin, Kiave-Yune Howangyin, Phatchanat Klaihmon, Coralie L Guerin, Marouane Kheloufi, José Vilar, Konstantinos Zannis, Bernd K Fleischmann, Do Won Hwang, Jongmin Park, Hakho Lee, Philippe Menasche, Jean-Sébastien Silvestre and Chantal M Boulanger

Circulation Research. 2018;CIRCRESAHA.117.311326, originally published March 28, 2018
https://doi.org/10.1161/CIRCRESAHA.117.311326

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Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of its Phosphorylation State
Shengbing Wang, Vidya Venkatraman, Erin L Crowgey, Ting Liu, Zongming Fu, Ronald J Holewinski, Mark J. J Ranek, David A Kass, Brian O'Rourke and Jennifer E Van Eyk

Circulation Research. 2018;CIRCRESAHA.118.312789, originally published March 21, 2018
https://doi.org/10.1161/CIRCRESAHA.118.312789

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Asb2α–Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart DevelopmentNovelty and Significance
Arnaud Métais, Isabelle Lamsoul, Armelle Melet, Sandrine Uttenweiler-Joseph, Renaud Poincloux, Sonia Stefanovic, Amélie Valière, Anne Gonzalez de Peredo, Alexandre Stella, Odile Burlet-Schiltz, Stéphane Zaffran, Pierre G. Lutz and Christel Moog-Lutz

Circulation Research. 2018;122:e34-e48, originally published January 26, 2018
https://doi.org/10.1161/CIRCRESAHA.117.312015

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