Circulation Research. 2006;99:816-828
doi: 10.1161/01.RES.0000246118.98832.04
doi: 10.1161/01.RES.0000246118.98832.04
© 2006 American Heart Association, Inc.
Reviews |
Compartmentation of Cyclic Nucleotide Signaling in the Heart
The Role of Cyclic Nucleotide Phosphodiesterases
iusFrom INSERM U769, Université Paris-Sud 11, Faculté de Pharmacie, Châtenay-Malabry, France. Current address for J.J.: Institute of Cardiology, Kaunas University of Medicine, Lithuania.
Correspondence to Rodolphe Fischmeister, INSERM U769, Faculté de Pharmacie, 5, Rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France. E-mail fisch{at}vjf.inserm.fr
This Review is part of a thematic series on Microdomains in Cardiovascular Signaling, which includes the following articles:
Caveolae and Caveolins in the Cardiovascular System
Focal Adhesion: Paradigm for a Signaling Nexus
Vesicular Trafficking of Tyrosine Kinase Receptors and Associated Proteins in the Regulation of Signaling and Vascular Function
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of A-Kinase Anchoring Proteins
Trafficking of G Protein–Coupled Receptors
Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases
Kathy K. Griendling and David A. Kass Editors
A current challenge in cellular signaling is to decipher the complex intracellular spatiotemporal organization that any given cell type has developed to discriminate among different external stimuli acting via a common signaling pathway. This obviously applies to cAMP and cGMP signaling in the heart, where these cyclic nucleotides determine the regulation of cardiac function by many hormones and neuromediators. Recent studies have identified cyclic nucleotide phosphodiesterases as key actors in limiting the spread of cAMP and cGMP, and in shaping and organizing intracellular signaling microdomains. With this new role, phosphodiesterases have been promoted from the rank of a housekeeping attendant to that of an executive officer.
Key Words: cAMP • cGMP • heart • G protein–coupled receptor • phosphodiesterase
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