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(Circulation Research. 2006;98:1014.)
© 2006 American Heart Association, Inc.

Reviews

Signaling and Functions of Angiopoietin-1 in Vascular Protection

Nicholas P.J. Brindle, Pipsa Saharinen, Kari Alitalo

From the Department of Cardiovascular Sciences (N.P.J.B.), University of Leicester, RKCSB, PO Box 65, Leicester LE2 7LX UK; and Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research Biomedicum Helsinki (P.S., K.A.), University of Helsinki, Finland.

Correspondence to Nicholas P.J. Brindle, University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester, LE2 7LX UK. E-mail npjb1{at}le.ac.uk

Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical studies indicate that Ang1 may be therapeutically useful in a number of situations, including treatment of edema, endotoxemia, and transplant arteriosclerosis. However, the ligand has also been implicated in vessel remodeling, induction of angiogenesis and pulmonary hypertension, indicating that strategies to minimize any deleterious effects while optimizing vessel protection are likely to be needed. This review surveys the published data on vascular protective effects of Ang1 and highlights the therapeutic potential of this ligand, as well as possible limitations to its use. We also consider the data on Ang1 receptors and speculate on how to maximize therapeutic benefit by targeting the Tie receptors.

Key Words: angiopoietin • endothelial • Tie1 • Tie2 • integrin

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