doi: 10.1161/01.RES.0000207406.94146.c2
© 2006 American Heart Association, Inc.
Reviews |
Diabetic Cardiomyopathy
The Search for a Unifying Hypothesis
From the Department of Medicine, Allegheny General Hospital, Pittsburgh; and the Drexel University College of Medicine, Philadelphia, Pa.
Correspondence to Richard P. Shannon, MD, Department of Medicine, Allegheny General Hospital, 320 East North Ave, Pittsburgh, PA 15212. E-mail rshannon{at}wpahs.org
This Review is part of a thematic series on Adipocyte Signaling in the Cardiovascular System, which includes the following articles:
Adipose Tissue, Inflammation, and Cardiovascular Disease
Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin Resistant Adipose Tissue
Diabetic Cardiomyopathy: The Search for a Unifying Hypothesis
Adipocyte Signaling and the Vasculature
PPAR
Activation and Effects on the Vasculature
Phillip Scherer Guest Editor
Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.
Key Words: insulin resistance • diabetic cardiomyopathy • diastolic function • cardiac hypertrophy
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