Circulation Research. 2004;95:858-866
doi: 10.1161/01.RES.0000146672.10582.17
doi: 10.1161/01.RES.0000146672.10582.17
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© 2004 American Heart Association, Inc.
Reviews |
Chemokines in the Pathogenesis of Vascular Disease
From the Gladstone Institute of Cardiovascular Disease (I.F.C.), San Francisco, Calif; Cardiovascular Research Institute (I.F.C.), Department of Medicine, University of California, San Francisco; and the Center for Cellular and Molecular Cardiology, Aab Institute of Biomedical Sciences and Department of Medicine (M.B.T.), University of Rochester, Rochester, NY.
Correspondence to Israel F. Charo, MD, PhD, Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141-9100; E-mail icharo{at}gladstone.ucsf.edu; and to Mark B. Taubman, Mark B. Taubman, MD, University of Rochester, Box 679-CCMC, 601 Elmwood Ave, Rochester, NY 14642. E-mail: mark_taubman{at}urmc.rochester.edu
This Review is part of a thematic series on Chemokines and Cytokines, which includes the following articles:
Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future
Inflammatory Cytokines and Postmyocardial Infarction Remodeling
Chemokines in the Pathogenesis of Vascular Disease
Cytokines in Ventricular Function
Peter Liu Guest Editor
Our increasing appreciation of the importance of inflammation in vascular disease has focused attention on the molecules that direct the migration of leukocytes from the blood stream to the vessel wall. In this review, we summarize roles of the chemokines, a family of small secreted proteins that selectively recruit monocytes, neutrophils, and lymphocytes to sites of vascular injury, inflammation, and developing atherosclerosis. Chemokines induce chemotaxis through the activation of G-protein-coupled receptors, and the receptors that a given leukocyte expresses determines the chemokines to which it will respond. Monocyte chemoattractant protein 1 (MCP-1), acting through its receptor CCR2, appears to play an early and important role in the recruitment of monocytes to atherosclerotic lesions and in the formation of intimal hyperplasia after arterial injury. Acute thrombosis is an often fatal complication of atherosclerotic plaque rupture, and recent evidence suggests that MCP-1 contributes to thrombin generation and thrombus formation by generating tissue factor. Because of their critical roles in monocyte recruitment in vascular and nonvascular diseases, MCP-1 and CCR2 have become important therapeutic targets, and efforts are underway to develop potent and specific antagonists of these and related chemokines.
Key Words: chemokine • CCR2 • vascular • atherosclerosis • monocyte chemoattractant protein 1
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J. Ma, Q. Wang, T. Fei, J.-D. J. Han, and Y.-G. Chen MCP-1 mediates TGF-{beta}-induced angiogenesis by stimulating vascular smooth muscle cell migration Blood, February 1, 2007; 109(3): 987 - 994. [Abstract] [Full Text] [PDF]
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R. Gyurko, C. C. Siqueira, N. Caldon, L. Gao, A. Kantarci, and T. E. Van Dyke Chronic Hyperglycemia Predisposes to Exaggerated Inflammatory Response and Leukocyte Dysfunction in Akita Mice J. Immunol., November 15, 2006; 177(10): 7250 - 7256. [Abstract] [Full Text] [PDF]
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G. Guo, P. Booms, M. Halushka, H. C. Dietz, A. Ney, S. Stricker, J. Hecht, S. Mundlos, and P. N. Robinson Induction of Macrophage Chemotaxis by Aortic Extracts of the mgR Marfan Mouse Model and a GxxPG-Containing Fibrillin-1 Fragment Circulation, October 24, 2006; 114(17): 1855 - 1862. [Abstract] [Full Text] [PDF]
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S.-l. Li, M. A. Reddy, Q. Cai, L. Meng, H. Yuan, L. Lanting, and R. Natarajan Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice Diabetes, September 1, 2006; 55(9): 2611 - 2619. [Abstract] [Full Text] [PDF]
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P. K. Henke, C. G. Pearce, D. M. Moaveni, A. J. Moore, E. M. Lynch, C. Longo, M. Varma, N. A. Dewyer, K. B. Deatrick, G. R. Upchurch Jr, et al. Targeted Deletion of CCR2 Impairs Deep Vein Thombosis Resolution in a Mouse Model. J. Immunol., September 1, 2006; 177(5): 3388 - 3397. [Abstract] [Full Text] [PDF]
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P. Liu, S. Patil, M. Rojas, A. M. Fong, S. S. Smyth, and D. D. Patel CX3CR1 Deficiency Confers Protection From Intimal Hyperplasia After Arterial Injury Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 2056 - 2062. [Abstract] [Full Text] [PDF]
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C. Herder, J. Baumert, B. Thorand, S. Martin, H. Lowel, H. Kolb, and W. Koenig Chemokines and Incident Coronary Heart Disease: Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002 Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 2147 - 2152. [Abstract] [Full Text] [PDF]
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A. Zernecke, E. A. Liehn, J.-L. Gao, W. A. Kuziel, P. M. Murphy, and C. Weber Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10 Blood, June 1, 2006; 107(11): 4240 - 4243. [Abstract] [Full Text] [PDF]
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K. Bidzhekov, A. Zernecke, and C. Weber MCP-1 Induces a Novel Transcription Factor With Proapoptotic Activity Circ. Res., May 12, 2006; 98(9): 1107 - 1109. [Full Text] [PDF]
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J. Suzuki, M. Iwai, M. Mogi, A. Oshita, T. Yoshii, J. Higaki, and M. Horiuchi Eplerenone With Valsartan Effectively Reduces Atherosclerotic Lesion by Attenuation of Oxidative Stress and Inflammation Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 917 - 921. [Abstract] [Full Text] [PDF]
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S. H. Durand, V. Flacher, A. Romeas, F. Carrouel, E. Colomb, C. Vincent, H. Magloire, M.-L. Couble, F. Bleicher, M.-J. Staquet, et al. Lipoteichoic Acid Increases TLR and Functional Chemokine Expression while Reducing Dentin Formation in In Vitro Differentiated Human Odontoblasts. J. Immunol., March 1, 2006; 176(5): 2880 - 2887. [Abstract] [Full Text] [PDF]
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Y. Zhang and L. M. Wahl Synergistic enhancement of cytokine-induced human monocyte matrix metalloproteinase-1 by C-reactive protein and oxidized LDL through differential regulation of monocyte chemotactic protein-1 and prostaglandin E2 J. Leukoc. Biol., January 1, 2006; 79(1): 105 - 113. [Abstract] [Full Text] [PDF]
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C. Weber Killing Two Birds With One Stone: Targeting Chemokine Receptors in Atherosclerosis and HIV Infection Arterioscler Thromb Vasc Biol, December 1, 2005; 25(12): 2448 - 2450. [Full Text] [PDF]
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T. Palmerini, A. Marzocchi, C. Marrozzini, P. Ortolani, F. Saia, L. Bacchi-Reggiani, S. Virzi, S. Gianstefani, and A. Branzi Preprocedural Levels of C-Reactive Protein and Leukocyte Counts Predict 9-Month Mortality After Coronary Angioplasty for the Treatment of Unprotected Left Main Coronary Artery Stenosis Circulation, October 11, 2005; 112(15): 2332 - 2338. [Abstract] [Full Text] [PDF]
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T. Suganami, J. Nishida, and Y. Ogawa A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes: Role of Free Fatty Acids and Tumor Necrosis Factor {alpha} Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2062 - 2068. [Abstract] [Full Text] [PDF]
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Y. Izumi, S. Kim-Mitsuyama, M. Yoshiyama, T. Omura, M. Shiota, A. Matsuzawa, T. Yukimura, T. Murohara, M. Takeya, H. Ichijo, et al. Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-Induced Angiogenesis Arterioscler Thromb Vasc Biol, September 1, 2005; 25(9): 1877 - 1883. [Abstract] [Full Text] [PDF]
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E. J. Harvey and D. P. Ramji Interferon-{gamma} and atherosclerosis: Pro- or anti-atherogenic? Cardiovasc Res, July 1, 2005; 67(1): 11 - 20. [Abstract] [Full Text] [PDF]
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R. Wessely Interference by interferons: Janus faces in vascular proliferative diseases Cardiovasc Res, June 1, 2005; 66(3): 433 - 443. [Abstract] [Full Text] [PDF]
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B. S. Coller Leukocytosis and Ischemic Vascular Disease Morbidity and Mortality: Is It Time to Intervene? Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 658 - 670. [Abstract] [Full Text] [PDF]
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