doi: 10.1161/01.RES.0000147619.96113.51
© 2004 American Heart Association, Inc.
Editorials |
Cardiac Regeneration
Self-Service at the Pump
From the Departments of Internal Medicine (D.J.G., C.M.M.) and Molecular Biology (D.J.G.), and The Donald W. Reynolds Cardiovascular Clinical Research Center (D.J.G.), University of Texas Southwestern Medical Center, Dallas.
Correspondence to Daniel J. Garry, MD, PhD, NB11.118A, 5323 Harry Hines Blvd, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573. E-mail daniel.garry@utsouthwestern.edu
See related article, pages 911–921
Key Words: heart failure • stem cells • heart • cardiospheres • c-kit • Sca-1 • Abcg2
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
Despite current pharmacological and whole organ transplantation strategies, advanced heart failure remains a common and deadly disease.1 Limited availability of donor organs for use in orthotopic heart transplantation has prompted examination of alternative therapeutic strategies directed toward patients with advanced heart failure. Intense interest has recently focused on cell transfer strategies or the mobilization of resident stem cells as strategies that may enhance the repair or regenerative capacity of the myopathic heart.
Cell Transfer Strategies as a Platform for Myocardial Repair
Cell transfer therapies have been used successfully to treat chronic and life-threatening diseases. An effective cell transfer therapy is bone marrow transplantation (BMT); allogeneic and autologous stem cell sources have been used successfully for BMT for >35 years.2 An enhanced understanding of immunosuppression therapy, immunological barriers, and stem cell biology have collectively resulted in >17 000 BMT procedures performed last year by 
200 US centers for the successful treatment of otherwise lethal diseases. The proven efficacy of this therapy using somatic stem cells underscores the potential of adult stem cells and provides further rationale for the applications of cell transfer strategies in disease treatment.2 Unlike BMT, use of cell transfer strategies for treatment of other debilitating and terminal diseases, such as muscular dystrophy, neurodegenerative disorders, diabetes, and advanced heart failure, has had limited or no success.3–5 This lack of success may be multifactorial and may be attributable to patient selection, cell source, timing of delivery (with regard to the onset of disease), decreased viability of cells after delivery (>90% cell death during the 72-hour period after delivery), milieu
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