Circulation Research. 2004;94:420-432
doi: 10.1161/01.RES.0000117583.66950.43
doi: 10.1161/01.RES.0000117583.66950.43
© 2004 American Heart Association, Inc.
Reviews |
Evidence for Mitochondrial K+ Channels and Their Role in Cardioprotection
From the Institute of Molecular Cardiobiology, Johns Hopkins University, Baltimore, Md.
Correspondence to Brian O’Rourke, PhD, Johns Hopkins University, Institute of Molecular Cardiobiology, 720 Rutland Ave, 844 Ross Bldg, Baltimore, MD 21205-2195. E-mail bor{at}jhmi.edu
This Review is part of a thematic series on Mitochondrial Dysfunction in Ischemia, which includes the following articles:
Role of the Mitochondrial Permeability Transition in Myocardial Disease
Primary and Secondary Signaling Pathways in Early Preconditioning That Converge on the Mitochondria to Produce Cardioprotection
Evidence for Mitochondrial K+ Channels and Their Role in Cardioprotection
Mitochondrial Death Pathways
Roberto Bolli Editor
Twenty years after the discovery of sarcolemmal ATP-sensitive K+ channels and 12 years after the discovery of mitochondrial KATP (mitoKATP) channels, progress has been remarkable, but many questions remain. In the case of the former, detailed structural information is available, and it is well accepted that the channel couples bioenergetics to cellular electrical excitability; however, in the heart, a clear physiological or pathophysiological role has yet to be defined. For mitoKATP, structural information is lacking, but there is abundant evidence linking the opening of the channel to protection against ischemia-reperfusion injury or apoptosis. This review updates recent progress in understanding the physiological role of mitoKATP and highlights outstanding questions and controversies, with the intent of stimulating additional investigation on this topic.
Key Words: ischemia • reperfusion • mitochondria • ATP-sensitive potassium channels • calcium-activated potassium channels
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