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(Circulation Research. 2004;94:e106.)
© 2004 American Heart Association, Inc.

Letters to the Editor

S-Nitrosoalbumin and Other S-Nitrosothiols in the Blood: Is Their Quantity of No Relevance?

Dimitrios Tsikas

Hannover Medical School, Institute of Clinical Pharmacology, Hannover, Germany, tsikas.dimitros@mh-hannover.de

An extract of the first 250 words of the full text is provided, because this article has no abstract.

To the Editor:

Similarity of results is the most appropriate criterion to assess agreement between methods and clinical measurements.¹ Reference intervals of a biochemical parameter are of particular importance for the definition of pathological conditions and the judgment of therapy success by pharmacological, nutritional, or physical measures. In this context, mass spectrometry is generally accepted as the gold standard.² Recent advances in the methods of analysis make it possible to suggest reference intervals for many members of the L-arginine/nitric oxide family, including asymmetric dimethylargine³ and 3-nitrotyrosine.⁴ Circulating S-nitrosothiols have evaded the definition of reference intervals to date. Stamler et al first reported on the presence of S-nitrosothiols in plasma of healthy humans of the order of 7000 nmol/L, with S-nitrosoalbumin suggested as the most abundant circulating S-nitrosothiol.⁵ At present, reported basal levels of circulating S-nitrosothiols range between 10 and 10 000 nmol/L.^6–12 The single reported mass spectrometric method revealed S-nitrosoalbumin mean basal plasma levels of 181 nmol/L.⁷

The physiological roles and the levels of S-nitrosothiols in the blood are the subject of active discussion.^13–17 In an editorial recently published in Circulation Research, Stamler¹⁷ commented on this issue and the recent studies by Ng et al¹⁰ and Massy et al,¹¹ but he did not consider critical contributions by other groups.^7,13,15,16 Stamler expressed the opinion that the quantitative aspect of the results is not very meaningful. I would agree with Stamler’s opinion, when the basal S-nitrosothiol levels are on the same order . . . [Full Text of this Article]

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				A. Hausladen, R. Rafikov, M. Angelo, D. J. Singel, E. Nudler, and J. S. Stamler Assessment of nitric oxide signals by triiodide chemiluminescence PNAS, February 13, 2007; 104(7): 2157 - 2162. [Abstract] [Full Text] [PDF]