doi: 10.1161/01.RES.0000128561.28701.ea
© 2004 American Heart Association, Inc.
Reviews |
Biology of Cardiac Arrhythmias
Ion Channel Protein Trafficking
From the Section of Cardiovascular Medicine, Departments of Medicine and Physiology, University of Wisconsin-Madison.
Correspondence to Dr Craig T. January, Room H6/354 Box 3248, Section of Cardiovascular Medicine, CSC, 600 Highland Ave, Madison, WI 53792. E-mail ctj{at}medicine.wisc.edu
This Review is part of a thematic series on the Biology of Cardiac Arrhythmias, which includes the following articles:
Antiarrhythmic Drug Target Choices and Screening
Inherited Arrhythmogenic Diseases: The Complexity Beyond Monogenic Disorders
Genomics in Sudden Cardiac Death
Regulation of Ion Channel Expression
Biology of Cardiac Arrhythmias: Ion Channel Protein Trafficking
Computational Insights: Chaos and Wave Theory
Gene Therapy and Cell Therapy of Cardiac Arrhythmias
This series is in honor of Harry A. Fozzard, 8th Editor of Circulation Research.
Gordon Tomaselli Editors
The mechanisms underlying normal and abnormal cardiac rhythms are complex and incompletely understood. Through the study of uncommon inheritable arrhythmia syndromes, including the long QT and Brugada syndromes, new insights are emerging. At the cellular and tissue levels, we now recognize that ion channel current is the sum of biophysical (gating, permeation), biochemical (phosphorylation, etc), and biogenic (biosynthesis, processing, trafficking, and degradation) properties. This review focuses on how heart cells process ion channel proteins and how this protein trafficking may be altered in some cardiac arrhythmia diseases. In this review, we honor Dr Harry A. Fozzard, a modern pioneer in cardiac arrhythmias, cell biology, and molecular electrophysiology. As a scientist and physician, his writings and mentorship have served to foster a generation of investigators who continue to bring this complex field toward greater scientific understanding and impact on humankind.
Key Words: arrhythmia • ion channels • protein trafficking • cell biology
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