Circulation Research. 2004;94:1408-1417
doi: 10.1161/01.RES.0000129178.56294.17
doi: 10.1161/01.RES.0000129178.56294.17
© 2004 American Heart Association, Inc.
Reviews |
Caveolae and Caveolins in the Cardiovascular System
From the Laboratory of Endothelial Cell Biology (J.-P.G.), Institut de Recherches Cliniques de Montreal (IRCM), Canada, and the Department of Pharmacology and Program in Vascular Cell Signaling and Therapeutics (P.B., W.C.S.), Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Conn.
Correspondence to Dr. William C. Sessa, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven CT 06536-0812. E-mail william.sessa{at}yale.edu
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
Key Words: caveolae • caveolins • signaling • phenotypes • nitric oxide
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