Circulation Research. 2003;93:802-805
Published online before print October 9, 2003, doi: 10.1161/01.RES.0000099504.30207.F5
Published online before print October 9, 2003, doi: 10.1161/01.RES.0000099504.30207.F5
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© 2003 American Heart Association, Inc.
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Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
From the Department of Cardiology (J.A.B., D.J.G., J.K.B., J.-M.L., C.G., A.C.C. A.M.S.), King’s College London, London, UK; Department of Biochemistry (J.D.L.), Emory University, Atlanta, Ga.
Correspondence to Professor A.M. Shah, Department of Cardiology, GKT School of Medicine, Bessemer Road, London, SE5 9PJ, UK. E-mail ajay.shah{at}kcl.ac.uk
Abstract
Increased production of reactive oxygen species (ROS) is implicated in the development of left ventricular hypertrophy (LVH). Phagocyte-type NADPH oxidases are major cardiovascular sources of ROS, and recent data indicate a pivotal role of a gp91phox-containing NADPH oxidase in angiotensin II (Ang II)–induced LVH. We investigated the role of this oxidase in pressure-overload LVH. gp91phox-/- mice and matched controls underwent chronic Ang II infusion or aortic constriction. Ang II–induced increases in NADPH oxidase activity, atrial natriuretic factor (ANF) expression, and cardiac mass were inhibited in gp91phox-/- mice, whereas aortic constriction-induced increases in cardiac mass and ANF expression were not inhibited. However, aortic constriction increased cardiac NADPH oxidase activity in both gp91phox-/- and wild-type mice. Myocardial expression of an alternative gp91phox isoform, Nox4, was upregulated after aortic constriction in gp91phox-/- mice. The antioxidant, N-acetyl-cysteine, inhibited pressure-overload–induced LVH in both gp91phox-/- and wild-type mice. These data suggest a differential response of the cardiac Nox isoforms, gp91phox and Nox4, to Ang II versus pressure overload.
Key Words: reactive oxygen species • hypertrophy • pressure overload • angiotensin • NADPH oxidase
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