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(Circulation Research. 2003;92:953.)
© 2003 American Heart Association, Inc.

Reviews

Genome Informatics

Current Status and Future Prospects

Raimond L. Winslow, Mark S. Boguski

From The Whitaker Biomedical Engineering Institute and Center for Cardiovascular Bioinformatics and Modeling (R.L.W.), The Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, Md; and the Human Biology Division (M.S.B.), Fred Hutchinson Cancer Research Center, Seattle, Wash.

Correspondence to Raimond L. Winslow, PhD, Room 201B Clark Hall, The Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218. E-mail rwinslow{at}bme.jhu.edu

Gordon F. Tomaselli Editor This Review is part of a thematic series on Emerging Genomics Technology, which includes the following articles:DNA Microarrays: Implications for Cardiovascular MedicineSerial Analysis of Gene Expression: Technical Considerations and Applications to Cardiovascular BiologyGenome Informatics: Current Status and Future ProspectsTechnical Aspects of Screening for Genes or SNPs

This article reviews recent advances in genomics and informatics relevant to cardiovascular research. In particular, we review the status of (1) whole genome sequencing efforts in human, mouse, rat, zebrafish, and dog; (2) the development of data mining and analysis tools; (3) the launching of the National Heart, Lung, and Blood Institute Programs for Genomics Applications and Proteomics Initiative; (4) efforts to characterize the cardiac transcriptome and proteome; and (5) the current status of computational modeling of the cardiac myocyte. In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape.

Key Words: cardiovascular genomics • transcriptome • proteome • modeling

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