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(Circulation Research. 2003;92:819.)
© 2003 American Heart Association, Inc.

Editorials

Endothelial Dysfunction and LOX-1

Forty Years From Muscle to Endothelium

Tomoh Masaki

From the Osaka Seikei University, Osaka, Japan.

Correspondence to Tomoh Masaki, MD, PhD, President, Osaka Seikei University, 3-10-62 Aikawa, Higashi-Yodogawa-ku, Osaka 533-0007, Japan. E-mail masakit@osaka-seikei.ac.jp

Key Words: endothelium • LOX-1 • endothelial dysfunction • oxidized LDL • endothelin

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Discovery of a new function of vascular endothelium has opened new horizons in the research field of vascular biology. Today, we cannot talk about vascular diseases without endothelial function. I am happy to have participated in the development of this field in those days.

In 1963, after graduating from the medical school at the University of Tokyo and finishing my internship, I entered the laboratory of Setsuro Ebashi who established the concept of calcium ion in intracellular signaling system, at the University of Tokyo.

I started purification of -actinin in his laboratory, which was originally found by Ebashi. I demonstrated the existence of -actinin at the Z-line of striated muscle and elucidated the structure and function of the protein. Thus -actinin was established as a muscle protein. Furthermore, through the same line of experimentation, I also found M-protein.

The development of muscle has also been one of my interests. In the early 1970s, I found the existence of several different types of myosin existing in different types of muscle by immunochemical methods. In addition, I also demonstrated that embryonic skeletal and/or cardiac muscle has a unique type of myosin, which is different from adult myosin, and that those embryonic myosin (and also troponin) changed during the development of muscle in each muscle type. These results elicited the worldwide explosion of investigation into the isoform change of muscle protein, not only in development but also in pathological state of muscle. These results were highly motivating to the study of the molecular . . . [Full Text of this Article]

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