Circulation Research. 2003;92:1079-1088
doi: 10.1161/01.RES.0000072977.86706.23
doi: 10.1161/01.RES.0000072977.86706.23
© 2003 American Heart Association, Inc.
Reviews |
Roles of Cardiac Transcription Factors in Cardiac Hypertrophy
From the Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Correspondence to Issei Komuro, Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. E mail komuro-tky{at}umin.ac.jp
Ryozo Nagai Guest Editor This Review is part of a thematic series on Gene Expression in Hypertrophy and Stress, which includes the following articles:Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac HypertrophyRoles of Cardiac Transcription Factors in Cardiac HypertrophyRas, Akt, and Mechanotransduction in the Cardiac MyocyteG Protein–Coupled Signaling and Gene ExpressionGenetic Models and Mechanisms of Transcription in Cardiac Hypertrophy
Different cell types, equipped with unique structure and function, synthesize different sets of proteins on the basis of different patterns of gene expression, even though their genomes are identical. Cardiac transcription factors have been reported to control a cardiac gene program and thus to play a crucial role in transcriptional regulation during embryogenesis. Recently, postnatal roles of cardiac transcription factors have been extensively investigated. Consistent with the direct transactivation of numerous cardiac genes reactivated in response to hypertrophic stimulation, cardiac transcription factors are profoundly involved in the generation of cardiac hypertrophy or in cardioprotection from cytotoxic stress in the adult heart. In this review, the regulation of a cardiac gene program by cardiac transcription factors is summarized, with an emphasis on their potential role in the generation of cardiac hypertrophy.
Key Words: cardiac transcription factors • gene expression • cardiac hypertrophy • cardiogenesis
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