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(Circulation Research. 2002;91:278.)
© 2002 American Heart Association, Inc.

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Short-Term Treatment With Ranolazine Improves Mechanical Efficiency in Dogs With Chronic Heart Failure

Margaret P. Chandler, William C. Stanley, Hideaki Morita, George Suzuki, Bridgette A. Roth, Brent Blackburn, Andrew Wolff, Hani N. Sabbah

From the Department of Medicine (H.M., G.S., H.N.S.), Henry Ford Heart and Vascular Institute, Detroit, Mich; Department of Physiology and Biophysics (M.P.C., W.C.S., B.A.R.), Case Western Reserve University, Cleveland, Ohio; and CV Therapeutics (B.B., A.W.), Palo Alto, Calif.

Correspondence to Hani N. Sabbah, PhD, Director of Cardiovascular Research, Henry Ford Heart and Vascular Institute, 2799 W Grand Blvd, Detroit, MI 48202. E-mail hsabbah1{at}hfhs.org

Abstract

The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MO₂) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MO₂ and LV mechanical efficiency increased (22.4±2.8% to 30.9±3.4% (P<0.05). In contrast, dobutamine significantly increased MO₂ and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in MO₂, resulting in an increased myocardial mechanical efficiency in dogs with HF.

Key Words: heart failure • mechanical efficiency • myocardial metabolism • fatty acids

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