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(Circulation Research. 2002;91:1114.)
© 2002 American Heart Association, Inc.

MiniReview

Brugada Syndrome

A Decade of Progress

C. Antzelevitch, P. Brugada, J. Brugada, R. Brugada, W. Shimizu, I. Gussak, A.R. Perez Riera

From the Masonic Medical Research Laboratory (C.A.), Utica, NY; Cardiovascular Center (P.B.), OLV Hospital, Aalst, Belgium; Cardiovascular Institute (J.B.), Hospital Clinic, University of Barcelona, Spain; National Cardiovascular Center (R.B.), Osaka, Japan; eResearchTechnology, Inc (I.G.), Bridgewater, NJ; and Cardiology Service (A.R.P.R.), Hemodynamic Laboratory, Neomater Hospital, São Paulo, Brazil.

Correspondence to Dr Charles Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501. E-mail ca{at}mmrl.edu

Eduardo Marbán for the Editors The Editors commissioned this MiniReview to celebrate the 10th anniversary of the description of the Brugada syndrome and to highlight the First Virtual Symposium About the Brugada Syndrome (http://www.brugada-symposium.org/).

Abstract

The Brugada syndrome has gained wide recognition throughout the world and today is believed to be responsible for 4% to 12% of all sudden deaths and 20% of deaths in patients with structurally normal hearts. The incidence of the disease is on the order of 5 per 10 000 inhabitants and, apart from accidents, is the leading cause of death of men under the age of 50 in regions of the world where the inherited syndrome is endemic. This minireview briefly summarizes the progress made over the past decade in our understanding of the clinical, genetic, cellular, ionic, and molecular aspects of this disease.

Key Words: ventricular tachycardia • ventricular fibrillation • arrhythmia • sudden death

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