doi: 10.1161/01.RES.0000047874.80576.5A
© 2002 American Heart Association, Inc.
Editorials |
Bioactive Peptide Signaling Within the Myocardial Interstitium and the Matrix Metalloproteinases
From the Medical University of South Carolina, Charleston, SC.
Correspondence to Francis G. Spinale, MD, PhD, Cardiothoracic Surgery, Room 625, Strom Thurmond Research Building, 770 MUSC Complex, Medical University of South Carolina, 114 Doughty St, Charleston, SC 29425.
Key Words: brain natriuretic peptide • fibroblasts • matrix metalloproteinases • remodeling
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
In response to a prolonged cardiovascular pathophysiological stimulus, a cascade of compensatory structural events occurs within the myocardium. This process occurs as a continuum and has been defined as myocardial remodeling. This remodeling process has been demonstrated within the myocardial compartment after myocardial infarction (MI), with hypertrophy, or in cardiomyopathic disease. Pharmacological interventions targeted at altering the adverse LV myocardial remodeling processes that invariably occur in these cardiac disease states hold therapeutic promise. Although myocardial remodeling is accompanied by changes in the cellular constituents of the LV myocardium, significant alterations in the structure and composition of the extracellular matrix (ECM) also occur. Moreover, it has become increasingly evident that the fibrillar collagen matrix of the myocardial ECM is not a static structure, but rather a dynamic entity that may play a fundamental role in myocardial adaptation to a pathological stress and thereby facilitate the remodeling process. Therefore, identification and understanding of the biological systems responsible for ECM synthesis and degradation within the myocardium holds particular relevance. In this issue, Tsuruda and colleagues1 from the Mayo Clinic report on the interactive effects of brain natriuretic peptide (BNP) and tumor necrosis factor-
(TNF-) on determinants of fibrillar collagen biosynthesis in cardiac fibroblasts. The results from this study emphasize the fact that the biologically active molecules that are contained within the myocardial interstitium do not act independently, but instead, a summation of signaling events ultimately determines the structure and function of the ECM.
Myocardial Fibroblast
The fibroblast is the most numerous cell type within
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