Circulation Research. 2002;90:377-379
Published online before print February 7, 2002, doi: 10.1161/01.RES.0000012567.95445.55
Published online before print February 7, 2002, doi: 10.1161/01.RES.0000012567.95445.55
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© 2002 American Heart Association, Inc.
Reports |
Phosphorylation of Glycogen Synthase Kinase-3ß During Preconditioning Through a Phosphatidylinositol-3-Kinase–Dependent Pathway Is Cardioprotective
From the Laboratory of Signal Transduction (H.T, K.I. E.M.), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and Department of Pathology (C.S.), Duke University Medical Center, Durham, NC.
Correspondence to Elizabeth Murphy, NIEHS, Research Triangle Park, NC 27709. E-mail murphy1{at}niehs.nih.gov
Abstract
We previously reported that activation of phosphatidylinositol-3-kinase (PI3-kinase) is involved in ischemic preconditioning (PC). Our goal was to determine downstream targets of PI3-kinase. In perfused rat hearts, PC (4 cycles of 5 minutes of ischemia and 5 minutes of reflow) increased phosphorylation of glycogen synthase kinase-3ß (GSK-3ß), a downstream target of PI3-kinase and protein kinase B (PKB), an effect that was blocked by wortmannin. Because phosphorylation inactivates GSK-3ß, we examined whether PC-induced phosphorylation and inhibition of GSK-3ß is important in PC by using two inhibitors of GSK-3ß, lithium and SB 216763. Pretreatment of perfused rat hearts with lithium or SB 216763, before ischemia, mimicked the protective effects of PC; hearts treated with either lithium or SB 216763 had improved postischemic function and reduced infarct size. These findings indicate that inhibition of GSK-3ß is protective and that this PI3-kinase–dependent signaling pathway may play an important role in ischemic preconditioning.
Key Words: ischemic preconditioning • phosphatidylinositol-3-kinase • glycogen synthase kinase-3ß
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