Circulation Research. 2002;90:248-250
Published online before print January 24, 2002, doi: 10.1161/hh0302.105662
Published online before print January 24, 2002, doi: 10.1161/hh0302.105662
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© 2002 American Heart Association, Inc.
Reports |
Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries
From the Department of Pharmacology, University of Vermont, College of Medicine, Burlington, Vt. Present address for D.G.W. is Department of Physiology and Biophysics, University of Calgary, Alberta.
Correspondence to Dr J. Brayden, Department of Pharmacology, Given Medical Building, The University of Vermont, Burlington, VT 05405. E-mail brayden{at}salus.med.uvm.edu
Abstract
Elevation of intravascular pressure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and this response is a key element in blood flow regulation. However, the nature of pressure-induced depolarization has remained elusive. In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure. Antisense oligodeoxynucleotides to TRPC6 decreased TRPC6 protein expression and greatly attenuated arterial smooth muscle depolarization and constriction caused by elevated pressure in intact cerebral arteries. Suppressing the expression of this channel protein also reduced the current density of a major cation current in resistance artery smooth muscle cells. We propose that TRPC6 channels play an essential role in regulation of myogenic tone.
Key Words: myogenic tone • transient receptor potential channels • membrane otential • vascular smooth muscle
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D. F. Slish, D. G. Welsh, and J. E. Brayden Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2196 - H2201. [Abstract] [Full Text] [PDF]
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M. Ishiguro, C. B. Puryear, E. Bisson, C. M. Saundry, D. J. Nathan, S. R. Russell, B. I. Tranmer, and G. C. Wellman Enhanced myogenic tone in cerebral arteries from a rabbit model of subarachnoid hemorrhage Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2217 - H2225. [Abstract] [Full Text] [PDF]
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S. Veerareddy, C.-L. M. Cooke, P. N. Baker, and S. T. Davidge Vascular adaptations to pregnancy in mice: effects on myogenic tone Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2226 - H2233. [Abstract] [Full Text] [PDF]
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Y. P. R. Jarajapu and H. J. Knot Role of phospholipase C in development of myogenic tone in rat posterior cerebral arteries Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2234 - H2238. [Abstract] [Full Text] [PDF]
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E. VanBavel, O. Sorop, D. Andreasen, M. Pfaffendorf, and B. L. Jensen Role of T-type calcium channels in myogenic tone of skeletal muscle resistance arteries Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2239 - H2243. [Abstract] [Full Text] [PDF]
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J. Zhang, W. G. Wier, and M. P. Blaustein Mg2+ blocks myogenic tone but not K+-induced constriction: role for SOCs in small arteries Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2692 - H2705. [Abstract] [Full Text] [PDF]
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