Circulation Research. 2002;90:1055-1063
doi: 10.1161/01.RES.0000018952.70505.F1
doi: 10.1161/01.RES.0000018952.70505.F1
© 2002 American Heart Association, Inc.
Reviews |
Glycogen Synthase Kinase-3ß
A Novel Regulator of Cardiac Hypertrophy and Development
From the Department of Cell Biology and Molecular Medicine, Department of Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, Newark.
Correspondence to Junichi Sadoshima, MD, PhD, Cardiovascular Research Institute UMDNJ, New Jersey Medical School, 185 South Orange Ave, MSB G-609, Newark, NJ 07103-2714. E-mail sadoshju{at}umdnj.edu
Glycogen synthase kinase-3ß (GSK-3ß) is a ubiquitously expressed constitutively active serine/threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions, including development, metabolism, gene transcription, protein translation, cytoskeletal organization, cell cycle regulation, and apoptosis. The activity of GSK-3ß is negatively regulated by protein kinase B/Akt and by the Wnt signaling pathway. Increasing lines of evidence show that GSK-3ß is an essential negative regulator of cardiac hypertrophy and that the inhibition of GSK-3ß by hypertrophic stimuli is an important mechanism contributing to the development of cardiac hypertrophy. GSK-3ß also plays an important role in regulating cardiac development. In this review, the role of GSK-3ß in cardiac hypertrophy and development and the potential underlying mechanisms are discussed.
Key Words: glycogen synthase kinase-3&bgr • hypertrophy • development • Akt • Wnt pathway
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|
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|
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|
|
|
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|
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|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
Z. Cai and G. L. Semenza PTEN Activity Is Modulated During Ischemia and Reperfusion: Involvement in the Induction and Decay of Preconditioning Circ. Res., December 9, 2005; 97(12): 1351 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Park, Y.-R. Cho, H.-J. Kim, T. Higashimori, C. Danton, M.-K. Lee, A. Dey, B. Rothermel, Y.-B. Kim, A. Kalinowski, et al. Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in C57BL/6 Mice Diabetes, December 1, 2005; 54(12): 3530 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wohlschlaeger, K. J. Schmitz, C. Schmid, K. W. Schmid, P. Keul, A. Takeda, S. Weis, B. Levkau, and H. A. Baba Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes Cardiovasc Res, December 1, 2005; 68(3): 376 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S.-Y. Li, C. X Fang, N. S Aberle II, B. H Ren, A. F Ceylan-Isik, and J. Ren Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function J. Endocrinol., September 1, 2005; 186(3): 491 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
J. G. Tidball Mechanical signal transduction in skeletal muscle growth and adaptation J Appl Physiol, May 1, 2005; 98(5): 1900 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Montanari, H. Yin, E. Dobrzynski, J. Agata, H. Yoshida, J. Chao, and L. Chao Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats Diabetes, May 1, 2005; 54(5): 1573 - 1580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Kim, K. Yamaguchi, S.-H. Lee, P. K. Tithof, G. S. Sayler, J.-H. Yoon, and S. J. Baek Evaluation of Polycyclic Aromatic Hydrocarbons in the Activation of Early Growth Response-1 and Peroxisome Proliferator Activated Receptors Toxicol. Sci., May 1, 2005; 85(1): 585 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rahmani, J. T. Read, J. M. Carthy, P. C. McDonald, B. W. Wong, M. Esfandiarei, X. Si, Z. Luo, H. Luo, P. S. Rennie, et al. Regulation of the Versican Promoter by the {beta}-Catenin-T-cell Factor Complex in Vascular Smooth Muscle Cells J. Biol. Chem., April 1, 2005; 280(13): 13019 - 13028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Kuemmerle Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3{beta} activity Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G101 - G110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fiedler and K. C Wollert Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes Cardiovasc Res, August 15, 2004; 63(3): 450 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E Hardt and J. Sadoshima Negative regulators of cardiac hypertrophy Cardiovasc Res, August 15, 2004; 63(3): 500 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Vlasblom, A. Muller, R. J.P Musters, M. J Zuidwijk, C. van Hardeveld, W. J Paulus, and W. S Simonides Contractile arrest reveals calcium-dependent stimulation of SERCA2a mRNA expression in cultured ventricular cardiomyocytes Cardiovasc Res, August 15, 2004; 63(3): 537 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho GATA transcription factors in the developing and adult heart Cardiovasc Res, August 1, 2004; 63(2): 196 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 S. S. Castillo, J. Brognard, P. A. Petukhov, C. Zhang, J. Tsurutani, C. A. Granville, M. Li, M. Jung, K. A. West, J. G. Gills, et al. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Res., April 15, 2004; 64(8): 2782 - 2792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Force, K. Kuida, M. Namchuk, K. Parang, and J. M. Kyriakis Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease Circulation, March 16, 2004; 109(10): 1196 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Morris, E. E. Spangenburg, and F. W. Booth Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle J Appl Physiol, January 1, 2004; 96(1): 398 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Sugden Ras, Akt, and Mechanotransduction in the Cardiac Myocyte Circ. Res., December 12, 2003; 93(12): 1179 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Gupta, S. Mishra, S. Rastogi, M. Imai, O. Habib, and H. N. Sabbah Cardiac SR-coupled PP1 activity and expression are increased and inhibitor 1 protein expression is decreased in failing hearts Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2373 - H2381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wolfrum, D. Besser, E. Luca, and M. Stoffel From the Cover: Insulin regulates the activity of forkhead transcription factor Hnf-3{beta}/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization PNAS, September 30, 2003; 100(20): 11624 - 11629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Shin, H. J. Lee, M. Nishida, M.-S. Lee, R. Tamura, S. Yamashita, Y. Matsuzawa, I.-K. Lee, and G. Y. Koh Betacellulin and Amphiregulin Induce Upregulation of Cyclin D1 and DNA Synthesis Activity Through Differential Signaling Pathways in Vascular Smooth Muscle Cells Circ. Res., August 22, 2003; 93(4): 302 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 K.-W. Park, H.-M. Yang, S.-W. Youn, H.-J. Yang, I.-H. Chae, B.-H. Oh, M.-M. Lee, Y.-B. Park, Y.-S. Choi, H.-S. Kim, et al. Constitutively Active Glycogen Synthase Kinase-3{beta} Gene Transfer Sustains Apoptosis, Inhibits Proliferation of Vascular Smooth Muscle Cells, and Reduces Neointima Formation After Balloon Injury in Rats Arterioscler Thromb Vasc Biol, August 1, 2003; 23(8): 1364 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
H. Akazawa and I. Komuro Roles of Cardiac Transcription Factors in Cardiac Hypertrophy Circ. Res., May 30, 2003; 92(10): 1079 - 1088. [Abstract] [Full Text] [PDF]
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A. Sanbe, J. Gulick, M. C. Hanks, Q. Liang, H. Osinska, and J. Robbins Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain Promoter Circ. Res., April 4, 2003; 92(6): 609 - 616. [Abstract] [Full Text] [PDF]
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E. van Rooij, P. A. Doevendans, C. C. de Theije, F. A. Babiker, J. D. Molkentin, and L. J. De Windt Requirement of Nuclear Factor of Activated T-cells in Calcineurin-mediated Cardiomyocyte Hypertrophy J. Biol. Chem., December 6, 2002; 277(50): 48617 - 48626. [Abstract] [Full Text] [PDF]
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M. A. Sussman, A. McCulloch, and T. K. Borg Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy Circ. Res., November 15, 2002; 91(10): 888 - 898. [Abstract] [Full Text] [PDF]
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 A. MAASS, J.P. KONHILAS, B.L. STAUFFER, and L.A. LEINWAND From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 409 - 416. [Abstract] [PDF]
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