Circulation Research. 2001;89:168-173
Published online before print July 5, 2001, doi: 10.1161/hh1401.093314
Published online before print July 5, 2001, doi: 10.1161/hh1401.093314
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2001 American Heart Association, Inc.
Integrative Physiology |
Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice
From the Cardiovascular (S.-F.Y., R.T., M.D.L., Z.Y.W., K.M., M.S., B.I., J.S.I., M.-E.L., M.A.P.) and Pulmonary and Critical Care (M.D.L, M.A.P.) Divisions and the Department of Medicine (S.-F.Y., R.T., M.D.L., L.G.M, L.Z., J.S.I., V.J.D., M.-E.L., M.A.P), Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
Correspondence to Shaw-Fang Yet, PhD, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis St, Thorn 1127, Boston, MA 02115. E-mail syet{at}rics.bwh.harvard.edu
Abstract— Heme oxygenase (HO)-1 degrades the pro-oxidant heme and generates carbon monoxide and antioxidant bilirubin. We have previously shown that in response to hypoxia, HO-1–null mice develop infarcts in the right ventricle of their hearts and that their cardiomyocytes are damaged by oxidative stress. To test whether HO-1 protects against oxidative injury in the heart, we generated cardiac-specific transgenic mice overexpressing different levels of HO-1. By use of a Langendorff preparation, hearts from transgenic mice showed improved recovery of contractile performance during reperfusion after ischemia in an HO-1 dose–dependent manner. In vivo, myocardial ischemia and reperfusion experiments showed that infarct size was only 14.7% of the area at risk in transgenic mice compared with 56.5% in wild-type mice. Hearts from these transgenic animals had reduced inflammatory cell infiltration and oxidative damage. Our data demonstrate that overexpression of HO-1 in the cardiomyocyte protects against ischemia and reperfusion injury, thus improving the recovery of cardiac function.
Key Words: heart • infarction • Langendorff preparation • cytoprotection • inflammation
This article has been cited by other articles:
 |
|
 |
|
  Q. Li, Y. Guo, Q. Ou, C. Cui, W.-J. Wu, W. Tan, X. Zhu, L. B. Lanceta, S. K. Sanganalmath, B. Dawn, et al. Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by Upregulating Heme Oxygenase-1 Via a Nuclear Factor-{kappa}B-Dependent Pathway Circulation, September 29, 2009; 120(13): 1222 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Metabolism to Molecular Therapy Am. J. Respir. Cell Mol. Biol., September 1, 2009; 41(3): 251 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Takamiya, C.-C. Hung, S. R. Hall, K. Fukunaga, T. Nagaishi, T. Maeno, C. Owen, A. A. Macias, L. E. Fredenburgh, A. Ishizaka, et al. High-Mobility Group Box 1 Contributes to Lethality of Endotoxemia in Heme Oxygenase-1-Deficient Mice Am. J. Respir. Cell Mol. Biol., August 1, 2009; 41(2): 129 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Brunt, M. R. Tsuji, J. H. Lai, R. T. Kinobe, W. Durante, W. C. Claycomb, C. A. Ward, and L. G. Melo Heme Oxygenase-1 Inhibits Pro-Oxidant Induced Hypertrophy in HL-1 Cardiomyocytes Experimental Biology and Medicine, May 1, 2009; 234(5): 582 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Noyan-Ashraf, M. A. Momen, K. Ban, A.-M. Sadi, Y.-Q. Zhou, A. M. Riazi, L. L. Baggio, R. M. Henkelman, M. Husain, and D. J. Drucker GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice Diabetes, April 1, 2009; 58(4): 975 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Czibik, J. Sagave, V. Martinov, B. Ishaq, M. Sohl, I. Sefland, H. Carlsen, F. Farnebo, R. Blomhoff, and G. Valen Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice Cardiovasc Res, April 1, 2009; 82(1): 107 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Kinderlerer, I. Pombo Gregoire, S. S. Hamdulay, F. Ali, R. Steinberg, G. Silva, N. Ali, B. Wang, D. O. Haskard, M. P. Soares, et al. Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin Blood, February 12, 2009; 113(7): 1598 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Reichelt, L. Willems, B. A. Hack, J. N. Peart, and J. P. Headrick Cardiac and coronary function in the Langendorff-perfused mouse heart model Exp Physiol, January 1, 2009; 94(1): 54 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-O. Pyo, J. Nah, H.-J. Kim, J.-W. Chang, Y.-W. Song, D.-K. Yang, D.-G. Jo, H.-R. Kim, H.-J. Chae, S.-W. Chae, et al. Protection of Cardiomyocytes from Ischemic/Hypoxic Cell Death via Drbp1 and pMe2GlyDH in Cardio-specific ARC Transgenic Mice J. Biol. Chem., November 7, 2008; 283(45): 30707 - 30714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Scragg, M. L. Dallas, J. A. Wilkinson, G. Varadi, and C. Peers Carbon Monoxide Inhibits L-type Ca2+ Channels via Redox Modulation of Key Cysteine Residues by Mitochondrial Reactive Oxygen Species J. Biol. Chem., September 5, 2008; 283(36): 24412 - 24419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Patil, L. Bellner, G. Cullaro, K. H. Gotlinger, M. W. Dunn, and M. L. Schwartzman Heme Oxygenase-1 Induction Attenuates Corneal Inflammation and Accelerates Wound Healing after Epithelial Injury Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3379 - 3386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mito, R. Ozono, T. Oshima, Y. Yano, Y. Watari, Y. Yamamoto, A. Brydun, K. Igarashi, and M. Yoshizumi Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1 Hypertension, June 1, 2008; 51(6): 1570 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. G. Abraham and A. Kappas Pharmacological and Clinical Aspects of Heme Oxygenase Pharmacol. Rev., March 1, 2008; 60(1): 79 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Angeloni, E. Leoncini, M. Malaguti, S. Angelini, P. Hrelia, and S. Hrelia Role of quercetin in modulating rat cardiomyocyte gene expression profile Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1233 - H1243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kubo, T.-S. Li, R. Suzuki, B. Shirasawa, N. Morikage, M. Ohshima, S.-L. Qin, and K. Hamano Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H590 - H595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Frank, C. Kuhn, B. Brors, C. Hanselmann, M. Ludde, H. A. Katus, and N. Frey Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes: Evidence for a Stretch-Specific Gene Program Hypertension, February 1, 2008; 51(2): 309 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L'Abbate, D. Neglia, C. Vecoli, M. Novelli, V. Ottaviano, S. Baldi, R. Barsacchi, A. Paolicchi, P. Masiello, G. S. Drummond, et al. Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3532 - H3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Lee Physiogenomic strategies and resources to associate genes with rat models of heart, lung and blood disorders Exp Physiol, November 1, 2007; 92(6): 992 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Datla, G. J. Dusting, T. A. Mori, C. J. Taylor, K. D. Croft, and F. Jiang Induction of Heme Oxygenase-1 In Vivo Suppresses NADPH Oxidase Derived Oxidative Stress Hypertension, October 1, 2007; 50(4): 636 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu, X. Zhang, B. Qian, X. Min, X. Gao, C. Li, Y. Cheng, and J. Huang Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice Eur J Heart Fail, August 1, 2007; 9(8): 762 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, J. A. Simpson, K. R. Brunt, C. A. Ward, S. R. R. Hall, R. T. Kinobe, V. Barrette, M. Y. Tse, S. C. Pang, A. S. Pachori, et al. Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H48 - H59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Coaxum, T. M. Griffin, J. L. Martin, and R. Mestril Influence of PKC-{alpha} overexpression on HSP70 and cardioprotection Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2220 - H2226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gueler, J.-K. Park, S. Rong, T. Kirsch, C. Lindschau, W. Zheng, M. Elger, A. Fiebeler, D. Fliser, F. C. Luft, et al. Statins Attenuate Ischemia-Reperfusion Injury by Inducing Heme Oxygenase-1 in Infiltrating Macrophages Am. J. Pathol., April 1, 2007; 170(4): 1192 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Was, T. Cichon, R. Smolarczyk, D. Rudnicka, M. Stopa, C. Chevalier, J. J. Leger, B. Lackowska, A. Grochot, K. Bojkowska, et al. Overexpression of Heme Oxygenase-1 in Murine Melanoma: Increased Proliferation and Viability of Tumor Cells, Decreased Survival of Mice Am. J. Pathol., December 1, 2006; 169(6): 2181 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Stocker and M. A. Perrella Heme Oxygenase-1: A Novel Drug Target for Atherosclerotic Diseases? Circulation, November 14, 2006; 114(20): 2178 - 2189. [Full Text] [PDF]
|
|
|
|
|
|
F. Jiang, S. J. Roberts, S. r. Datla, and G. J. Dusting NO Modulates NADPH Oxidase Function Via Heme Oxygenase-1 in Human Endothelial Cells Hypertension, November 1, 2006; 48(5): 950 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yano, R. Ozono, Y. Oishi, M. Kambe, M. Yoshizumi, T. Ishida, S. Omura, T. Oshima, and K. Igarashi Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice. Genes Cells, July 1, 2006; 11(7): 791 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Kirkby and C. A. Adin Products of heme oxygenase and their potential therapeutic applications Am J Physiol Renal Physiol, March 1, 2006; 290(3): F563 - F571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Pachori, L. G. Melo, L. Zhang, S. D. Solomon, and V. J. Dzau Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery J. Am. Coll. Cardiol., February 7, 2006; 47(3): 635 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Dzau, M. Gnecchi, and A. S. Pachori Enhancing Stem Cell Therapy Through Genetic Modification J. Am. Coll. Cardiol., October 4, 2005; 46(7): 1351 - 1353. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. L. Tang, K. Qian, Y. C. Zhang, L. Shen, and M. I. Phillips A Vigilant, Hypoxia-Regulated Heme Oxygenase-1 Gene Vector in the Heart Limits Cardiac Injury After Ischemia-Reperfusion In Vivo Journal of Cardiovascular Pharmacology and Therapeutics, October 1, 2005; 10(4): 251 - 263. [Abstract] [PDF]
|
|
|
|
|
|
B. Dawn and R. Bolli HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H522 - H524. [Full Text] [PDF]
|
|
|
|
|
|
R. Ockaili, R. Natarajan, F. Salloum, B. J. Fisher, D. Jones, A. A. Fowler III, and R. C. Kukreja HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H542 - H548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-C. Fan, X. Ren, J. Qian, Q. Yuan, P. Nicolaou, Y. Wang, W. K. Jones, G. Chu, and E. G. Kranias Novel Cardioprotective Role of a Small Heat-Shock Protein, Hsp20, Against Ischemia/Reperfusion Injury Circulation, April 12, 2005; 111(14): 1792 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Vera, J. R. Henegar, H. A. Drummond, J. M. Rimoldi, and D. E. Stec Protective Effect of Carbon Monoxide-Releasing Compounds in Ischemia-Induced Acute Renal Failure J. Am. Soc. Nephrol., April 1, 2005; 16(4): 950 - 958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liu, J. Wei, D. H. Peng, M. D. Layne, and S.-F. Yet Absence of Heme Oxygenase-1 Exacerbates Myocardial Ischemia/Reperfusion Injury in Diabetic Mice Diabetes, March 1, 2005; 54(3): 778 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-m. Liu, K. J. Peyton, D. Ensenat, H. Wang, A. I. Schafer, J. Alam, and W. Durante Endoplasmic Reticulum Stress Stimulates Heme Oxygenase-1 Gene Expression in Vascular Smooth Muscle: ROLE IN CELL SURVIVAL J. Biol. Chem., January 14, 2005; 280(2): 872 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Hartsfield, I. F. McMurtry, D. D. Ivy, K. G. Morris, S. Vidmar, D. M. Rodman, and K. A. Fagan Cardioprotective and vasomotor effects of HO activity during acute and chronic hypoxia Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2009 - H2015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fujimoto, M. Ohno, S. Ayabe, H. Kobayashi, N. Ishizaka, H. Kimura, K.-i. Yoshida, and R. Nagai Carbon Monoxide Protects Against Cardiac Ischemia--Reperfusion Injury In Vivo via MAPK and Akt--eNOS Pathways Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1848 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. De Celle, J. P. Cleutjens, W. M. Blankesteijn, J. J. Debets, J. F. Smits, and B. J. Janssen Long-term structural and functional consequences of cardiac ischaemia-reperfusion injury in vivo in mice Exp Physiol, September 1, 2004; 89(5): 605 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tongers, B. Fiedler, D. Konig, T. Kempf, G. Klein, J. Heineke, T. Kraft, S. Gambaryan, S. M Lohmann, H. Drexler, et al. Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes Cardiovasc Res, August 15, 2004; 63(3): 545 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Hu, Y.-H. Chen, M.-T. Chiang, and L.-Y. Chau Heme Oxygenase-1 Inhibits Angiotensin II-Induced Cardiac Hypertrophy In Vitro and In Vivo Circulation, July 20, 2004; 110(3): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Jison, P. J. Munson, J. J. Barb, A. F. Suffredini, S. Talwar, C. Logun, N. Raghavachari, J. H. Beigel, J. H. Shelhamer, R. L. Danner, et al. Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease Blood, July 1, 2004; 104(1): 270 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Guo, A. B. Stein, W.-J. Wu, W. Tan, X. Zhu, Q.-H. Li, B. Dawn, R. Motterlini, and R. Bolli Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1649 - H1653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brenner, M. Jain, D. R. Pimentel, B. Wang, L. H. Connors, M. Skinner, C. S. Apstein, and R. Liao Human Amyloidogenic Light Chains Directly Impair Cardiomyocyte Function Through an Increase in Cellular Oxidant Stress Circ. Res., April 30, 2004; 94(8): 1008 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Oyama, C. Blais Jr, X. Liu, M. Pu, L. Kobzik, R. A. Kelly, and T. Bourcier Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice Circulation, February 17, 2004; 109(6): 784 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Tarnavski, J. R. McMullen, M. Schinke, Q. Nie, S. Kong, and S. Izumo Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies Physiol Genomics, February 13, 2004; 16(3): 349 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Skaar, A. H. Gaspar, and O. Schneewind IsdG and IsdI, Heme-degrading Enzymes in the Cytoplasm of Staphylococcus aureus J. Biol. Chem., January 2, 2004; 279(1): 436 - 443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Araujo, L. Meng, A. D. Tward, W. W. Hancock, Y. Zhai, A. Lee, K. Ishikawa, S. Iyer, R. Buelow, R. W. Busuttil, et al. Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse J. Immunol., August 1, 2003; 171(3): 1572 - 1580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-Y. Tsui, X. Wu, C.-K. Lau, D. W.Y. Ho, T. Xu, Y.-T. Siu, and S.-T. Fan Prevention of Chronic Deterioration of Heart Allograft by Recombinant Adeno-Associated Virus-Mediated Heme Oxygenase-1 Gene Transfer Circulation, May 27, 2003; 107(20): 2623 - 2629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Chen, S.-F. Yet, and M. A. Perrella Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function Experimental Biology and Medicine, May 1, 2003; 228(5): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Braudeau, D. Bouchet, C. Toquet, L. Tesson, S. Menoret, S. Iyer, C. Laboisse, D. Willis, A. Jarry, R. Buelow, et al. Generation of Heme Oxygenase-1-Transgenic Rats Experimental Biology and Medicine, May 1, 2003; 228(5): 466 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Grilli, M. A. De Lutiis, A. Patruno, L. Speranza, F. Gizzi, A. A. Taccardi, P. Di Napoli, R. De Caterina, P. Conti, and M. Felaco Inducible Nitric Oxide Synthase and Heme Oxygenase-1 in Rat Heart: Direct Effect of Chronic Exposure to Hypoxia Ann. Clin. Lab. Sci., April 1, 2003; 33(2): 208 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Vulapalli, Z. Chen, B. H. L. Chua, T. Wang, and C.-S. Liang Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H688 - H694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Morse and A. M. K. Choi Heme Oxygenase-1 . The "Emerging Molecule" Has Arrived Am. J. Respir. Cell Mol. Biol., July 1, 2002; 27(1): 8 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Sidell, M. A. Cole, N. J. Draper, M. Desrois, R. E. Buckingham, and K. Clarke Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart Diabetes, April 1, 2002; 51(4): 1110 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tang, M. Jackson, K. Qian, and M. I. Phillips Hypoxia Inducible Double Plasmid System for Myocardial Ischemia Gene Therapy Hypertension, February 1, 2002; 39(2): 695 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M.K. Choi Heme Oxygenase-1 Protects the Heart Circ. Res., July 20, 2001; 89(2): 105 - 107. [Full Text] [PDF]
|
|
|
|
|
|
L. G. Melo, R. Agrawal, L. Zhang, M. Rezvani, A. A. Mangi, A. Ehsan, D. P. Griese, G. Dell'Acqua, M. J. Mann, J. Oyama, et al. Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene Circulation, February 5, 2002; 105(5): 602 - 607. [Abstract] [Full Text] [PDF]
|
|