© 2000 American Heart Association, Inc.
Cellular Biology |
The ß2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3'-Kinase
From the Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Md.
Correspondence to Michael T. Crow, PhD, Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging-NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224. E-mail crowm{at}grc.nia.nih.gov
Abstract—Recent studies have shown that chronic ß-adrenergic receptor (ß-AR) stimulation alters cardiac myocyte survival in a receptor subtype-specific manner. We examined the effect of selective ß1- and ß2-AR subtype stimulation on apoptosis induced by hypoxia or H2O2 in rat neonatal cardiac myocytes. Although neither ß1- nor ß2-AR stimulation had any significant effect on the basal level of apoptosis, selective ß2-AR stimulation protected myocytes from apoptosis. ß2-AR stimulation markedly increased mitogen-activated protein kinase/extracellular signal–regulated protein kinase (MAPK/ERK) activation as well as phosphatidylinositol-3'-kinase (PI-3K) activity and Akt/protein kinase B phosphorylation. ß1-AR stimulation also markedly increased MAPK/ERK activation but only minimally activated PI-3K and Akt. Pretreatment with pertussis toxin blocked ß2-AR–mediated protection from apoptosis as well as the ß2-AR–stimulated changes in MAPK/ERK, PI-3K, and Akt/protein kinase B. The selective PI-3K inhibitor, LY 294002, also blocked ß2-AR–mediated protection, whereas inhibition of MAPK/ERK activation at an inhibitor concentration that blocked agonist-induced activation but not the basal level of activation had no effect on ß2-AR–mediated protection. These findings demonstrate that ß2-ARs activate a PI-3K–dependent, pertussis toxin–sensitive signaling pathway in cardiac myocytes that is required for protection from apoptosis-inducing stimuli often associated with ischemic stress.
Key Words: apoptosis • ß-adrenergic receptors • cardiomyocytes • hypoxia • phosphatidylinositol 3'-kinase • Gi proteins
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 H. Fujino and J. W. Regan EP4 Prostanoid Receptor Coupling to a Pertussis Toxin-Sensitive Inhibitory G Protein Mol. Pharmacol., January 1, 2006; 69(1): 5 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 L. Zhang Prenatal Hypoxia and Cardiac Programming Reproductive Sciences, January 1, 2005; 12(1): 2 - 13. [Abstract] [PDF]
|
|
|
|
|
|
V. Leblais, S.-H. Jo, K. Chakir, V. Maltsev, M. Zheng, M. T. Crow, W. Wang, E. G. Lakatta, and R.-P. Xiao Phosphatidylinositol 3-Kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes Circ. Res., December 10, 2004; 95(12): 1183 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
M. A Movsesian Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy Cardiovasc Res, June 1, 2004; 62(3): 450 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Heubach, U. Ravens, and A. J. Kaumann Epinephrine Activates Both Gs and Gi Pathways, but Norepinephrine Activates Only the Gs Pathway through Human {beta}2-Adrenoceptors Overexpressed in Mouse Heart Mol. Pharmacol., May 1, 2004; 65(5): 1313 - 1322. [Abstract] [Full Text]
|
|
|
|
|
|
G. E. Breitwieser G Protein-Coupled Receptor Oligomerization: Implications for G Protein Activation and Cell Signaling Circ. Res., January 9, 2004; 94(1): 17 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gaussin, J. E. Tomlinson, C. Depre, S. Engelhardt, C. L. Antos, G. Takagi, L. Hein, J. N. Topper, S. B. Liggett, E. N. Olson, et al. Common Genomic Response in Different Mouse Models of {beta}-Adrenergic-Induced Cardiomyopathy Circulation, December 9, 2003; 108(23): 2926 - 2933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
V. D. Nair and S. C. Sealfon Agonist-specific Transactivation of Phosphoinositide 3-Kinase Signaling Pathway Mediated by the Dopamine D2 Receptor J. Biol. Chem., November 21, 2003; 278(47): 47053 - 47061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Lohse, S. Engelhardt, and T. Eschenhagen What Is the Role of {beta}-Adrenergic Signaling in Heart Failure? Circ. Res., November 14, 2003; 93(10): 896 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-P. Xiao, S.-J. Zhang, K. Chakir, P. Avdonin, W. Zhu, R. A. Bond, C. W. Balke, E. G. Lakatta, and H. Cheng Enhanced Gi Signaling Selectively Negates {beta}2-Adrenergic Receptor (AR)- but Not {beta}1-AR-Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts Circulation, September 30, 2003; 108(13): 1633 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bae, Y. Xiao, G. Li, C. A. Casiano, and L. Zhang Effect of maternal chronic hypoxic exposure during gestation on apoptosis in fetal rat heart Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H983 - H990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Hu, W. Chen, N. P. Martin, E. J. Whalen, R. T. Premont, and R. J. Lefkowitz GIPC Interacts with the {beta}1-Adrenergic Receptor and Regulates {beta}1-Adrenergic Receptor-mediated ERK Activation J. Biol. Chem., July 3, 2003; 278(28): 26295 - 26301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Li, Y. Xiao, J. L. Estrella, C. A. Ducsay, R. D. Gilbert, and L. Zhang Effect of Fetal Hypoxia on Heart Susceptibility to Ischemia and Reperfusion Injury in the Adult Rat Reproductive Sciences, July 1, 2003; 10(5): 265 - 274. [Abstract] [PDF]
|
|
|
|
|
|
V. O. Rybin, E. Pak, S. Alcott, and S. F. Steinberg Developmental Changes in {beta}2-Adrenergic Receptor Signaling in Ventricular Myocytes: the Role of Gi proteins and Caveolae Microdomains Mol. Pharmacol., June 1, 2003; 63(6): 1338 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Cesetti, J. M. Hernandez-Guijo, P. Baldelli, V. Carabelli, and E. Carbone Opposite Action of beta 1- and beta 2-Adrenergic Receptors on CaV1 L-Channel Current in Rat Adrenal Chromaffin Cells J. Neurosci., January 1, 2003; 23(1): 73 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lavoie, J.-F. Mercier, A. Salahpour, D. Umapathy, A. Breit, L.-R. Villeneuve, W.-Z. Zhu, R.-P. Xiao, E. G. Lakatta, M. Bouvier, et al. beta 1/beta 2-Adrenergic Receptor Heterodimerization Regulates beta 2-Adrenergic Receptor Internalization and ERK Signaling Efficacy J. Biol. Chem., September 13, 2002; 277(38): 35402 - 35410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xiang, V. O. Rybin, S. F. Steinberg, and B. Kobilka Caveolar Localization Dictates Physiologic Signaling of beta 2-Adrenoceptors in Neonatal Cardiac Myocytes J. Biol. Chem., September 6, 2002; 277(37): 34280 - 34286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Kilts, T. Akazawa, M. D. Richardson, and M. M. Kwatra Age Increases Cardiac Galpha i2 Expression, Resulting in Enhanced Coupling to G Protein-coupled Receptors J. Biol. Chem., August 16, 2002; 277(34): 31257 - 31262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Crow Hypoxia, BNip3 Proteins, and the Mitochondrial Death Pathway in Cardiomyocytes Circ. Res., August 9, 2002; 91(3): 183 - 185. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shizukuda and P. M. Buttrick Oxygen free radicals and heart failure: new insight into an old question Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L237 - L238. [Full Text] [PDF]
|
|
|
|
|
|
E. N Dedkova, Y. Gao Wang, L. A Blatter, and S. L Lipsius Nitric oxide signalling by selective {beta}2-adrenoceptor stimulation prevents ACh-induced inhibition of {beta}2-stimulated Ca2+ current in cat atrial myocytes J. Physiol., August 1, 2002; 542(3): 711 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Jo, V. Leblais, P. H. Wang, M. T. Crow, and R.-P. Xiao Phosphatidylinositol 3-Kinase Functionally Compartmentalizes the Concurrent Gs Signaling During {beta}2-Adrenergic Stimulation Circ. Res., July 12, 2002; 91(1): 46 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gong, H. Sun, W. J. Koch, T. Rau, T. Eschenhagen, U. Ravens, J. F. Heubach, D. L. Adamson, and S. E. Harding Specific {beta}2AR Blocker ICI 118,551 Actively Decreases Contraction Through a Gi-Coupled Form of the {beta}2AR in Myocytes From Failing Human Heart Circulation, May 28, 2002; 105(21): 2497 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sabri, B. A. Wilson, and S. F. Steinberg Dual Actions of the G{alpha}q Agonist Pasteurella multocida Toxin to Promote Cardiomyocyte Hypertrophy and Enhance Apoptosis Susceptibility Circ. Res., May 3, 2002; 90(8): 850 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Feldman Deactivation of Vasodilator Responses by GRK2 Overexpression: A Mechanism or the Mechanism for Hypertension? Mol. Pharmacol., April 1, 2002; 61(4): 707 - 709. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaugg, M. C. Schaub, T. Pasch, and D. R. Spahn Modulation of {beta}-adrenergic receptor subtype activities in perioperative medicine: mechanisms and sites of action Br. J. Anaesth., January 1, 2002; 88(1): 101 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. G. Wang, E. N. Dedkova, S. F. Steinberg, L. A. Blatter, and S. L. Lipsius {beta}2-Adrenergic Receptor Signaling Acts via No Release to Mediate Ach-Induced Activation of Atp-Sensitive K+ Current in Cat Atrial Myocytes J. Gen. Physiol., January 1, 2002; 119(1): 69 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 R.-P. Xiao {beta}-Adrenergic Signaling in the Heart: Dual Coupling of the {beta}2-Adrenergic Receptor to Gs and Gi Proteins Sci. Signal., October 16, 2001; 2001(104): re15 - re15. [Abstract] [Full Text] [PDF]
|
|
|
|
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|
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|
|
|
|
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S. F. Steinberg The Cellular Actions of {beta}-Adrenergic Receptor Agonists : Looking Beyond cAMP Circ. Res., December 8, 2000; 87(12): 1079 - 1082. [Full Text] [PDF]
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M.-C. Wellner-Kienitz, K. Bender, and L. Pott Overexpression of beta 1 and beta 2 Adrenergic Receptors in Rat Atrial Myocytes. DIFFERENTIAL COUPLING TO G PROTEIN-GATED INWARD RECTIFIER K+ CHANNELS VIA Gs AND Gi/o J. Biol. Chem., September 28, 2001; 276(40): 37347 - 37354. [Abstract] [Full Text] [PDF]
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M. G. Vila Petroff, J. M. Egan, X. Wang, and S. J. Sollott Glucagon-Like Peptide-1 Increases cAMP but Fails to Augment Contraction in Adult Rat Cardiac Myocytes Circ. Res., August 31, 2001; 89(5): 445 - 452. [Abstract] [Full Text] [PDF]
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A. Sabri, B. A. Wilson, and S. F. Steinberg Dual Actions of the G{alpha}q Agonist Pasteurella multocida Toxin to Promote Cardiomyocyte Hypertrophy and Enhance Apoptosis Susceptibility Circ. Res., May 3, 2002; 90(8): 850 - 857. [Abstract] [Full Text] [PDF]
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