© 2000 American Heart Association, Inc.
Review |
The Role of Homeobox Genes in Vascular Remodeling and Angiogenesis
From the Division of Surgical Oncology (D.H.G.), UMDNJ–Robert Wood Johnson Medical School, the Cancer Institute of New Jersey, New Brunswick, and the Division of Cardiovascular Research (K.W.), Tufts University School of Medicine, St Elizabeth’s Medical Center, Boston, Mass.
Correspondence to Kenneth Walsh, PhD, Division of Cardiovascular Research, Tufts University School of Medicine, St Elizabeth’s Medical Center, 736 Cambridge St, Boston, MA 02135. E-mail kwalsh{at}opal.tufts.edu
Abstract—Homeodomain-containing transcription factors are critical in the regulation of cell proliferation, differentiation, and migration, and they play an important role in organogenesis and pattern formation during embryogenesis. There is evidence that some of them are oncogenes or tumor suppressors. The cardiovascular system undergoes extensive remodeling during embryogenesis and disease states such as atherosclerosis and tumor-induced angiogenesis, and homeobox genes may play an important role in regulating these processes. Recently, homeobox genes have been detected in both vascular smooth muscle and endothelial cells, and they are implicated in pathological processes such as arterial restenosis after balloon angioplasty and tumor-induced angiogenesis. The cellular function of some of these genes is beginning to be elucidated. Therefore, we briefly review what is currently known about the involvement of homeobox transcription factors in both physiological and pathological vascular remodeling and angiogenesis.
Key Words: genes, homeobox • endothelium • muscle, smooth, vascular
This article has been cited by other articles:
 |
|
 |
|
  S. Winnik, M. Klinkert, H. Kurz, C. Zoeller, J. Heinke, Y. Wu, C. Bode, C. Patterson, and M. Moser HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2 Cardiovasc Res, August 1, 2009; 83(3): 558 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, K. A. Burridge, and M. H. Friedman In vivo differences between endothelial transcriptional profiles of coronary and iliac arteries revealed by microarray analysis Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1556 - H1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bandyopadhyay, M. Z. Ashraf, P. Daher, P. H. Howe, and P. E. DiCorleto HOXA9 Participates in the Transcriptional Activation of E-Selectin in Endothelial Cells Mol. Cell. Biol., June 15, 2007; 27(12): 4207 - 4216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hara, S. Samuel, J. Liu, D. Rosen, R. R. Langley, and H. Naora A Homeobox Gene Related to Drosophila Distal-Less Promotes Ovarian Tumorigenicity by Inducing Expression of Vascular Endothelial Growth Factor and Fibroblast Growth Factor-2 Am. J. Pathol., May 1, 2007; 170(5): 1594 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Diehl, L. Rossig, A. M. Zeiher, S. Dimmeler, and C. Urbich The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation Blood, February 15, 2007; 109(4): 1472 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Mohri, Y. Fujio, M. Maeda, T. Ito, T. Iwakura, Y. Oshima, Y. Uozumi, M. Segawa, H. Yamamoto, T. Kishimoto, et al. Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells J. Biol. Chem., March 10, 2006; 281(10): 6442 - 6447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Garcia-Ramirez, J. Martinez-Gonzalez, J. O. Juan-Babot, C. Rodriguez, and L. Badimon Transcription Factor SOX18 Is Expressed in Human Coronary Atherosclerotic Lesions and Regulates DNA Synthesis and Vascular Cell Growth Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2398 - 2403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. El-Mounayri, J. W. Triplett, C. W. Yates, and B. P. Herring Regulation of Smooth Muscle-specific Gene Expression by Homeodomain Proteins, Hoxa10 and Hoxb8 J. Biol. Chem., July 8, 2005; 280(27): 25854 - 25863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Rossig, C. Urbich, T. Bruhl, E. Dernbach, C. Heeschen, E. Chavakis, K.-i. Sasaki, D. Aicher, F. Diehl, F. Seeger, et al. Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells J. Exp. Med., June 6, 2005; 201(11): 1825 - 1835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang, Y. Zhen, Y. Shi, J. Chen, C. Zhang, X. Wang, X. Yang, Y. Zheng, Y. Liu, and R. Hui Vitamin K Epoxide Reductase: A Protein Involved in Angiogenesis Mol. Cancer Res., June 1, 2005; 3(6): 317 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Seo, T. Wang, H. Dressman, E. E. Herderick, E. S. Iversen, C. Dong, K. Vata, C. A. Milano, F. Rigat, J. Pittman, et al. Gene Expression Phenotypes of Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1922 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bruhl, C. Urbich, D. Aicher, A. Acker-Palmer, A. M. Zeiher, and S. Dimmeler Homeobox A9 Transcriptionally Regulates the EphB4 Receptor to Modulate Endothelial Cell Migration and Tube Formation Circ. Res., April 2, 2004; 94(6): 743 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Grzesik and A.S. Narayanan CEMENTUM AND PERIODONTAL WOUND HEALING AND REGENERATION Critical Reviews in Oral Biology & Medicine, November 1, 2002; 13(6): 474 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Gorski and K. Walsh Control of Vascular Cell Differentiation by Homeiobox Transcription Factors Circ. Res., January 19, 2001; 88(1): 7 - 8. [Full Text] [PDF]
|
|
|
|
|
|
F. S. Jones, R. Meech, D. B. Edelman, R. J. Oakey, and P. L. Jones Prx1 Controls Vascular Smooth Muscle Cell Proliferation and Tenascin-C Expression and Is Upregulated With Prx2 in Pulmonary Vascular Disease Circ. Res., July 20, 2001; 89(2): 131 - 138. [Abstract] [Full Text] [PDF]
|
|