© 1999 American Heart Association, Inc.
Editorials |
The Intima
A New Soil
From the Department of Pathology, University of Washington, Seattle.
Correspondence to Stephen M. Schwartz, MD, PhD, Vascular Biology, Box 357335, University of Washington, Seattle, WA 98195-7335. E-mail steves@u.washington.edu
Key Words: intima • atherosclerosis • atherosclerotic lesion • coronary artery
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Introduction |
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Weninger and colleagues,1 in this issue of Circulation Research, have simply and elegantly reported on a piece of fundamental arterial biology totally unexplored before: the developmental origins of the intima in the siphon of the internal carotid artery. This site was chosen for study because the parasellar internal carotid artery in adults has the unwelcome fate of being highly prone to atherosclerosis at a site where the outcome is stroke. Moreover, this site, like the origin of the left anterior descending coronary artery, develops a focal intimal thickening long before the usual changes of lipid accumulation, characterized as "atherosclerosis," occur. It is very reasonable, therefore, to consider the developmental biology of such sites as very early events that set the scene for localization of atherosclerosis in adults. Particularly intriguing is their evidence that the shape of the vessel, rather than the flow patterns, may determine the degree of intimal hyperplasia and ultimately constitute a risk factor for development of clinically important lesions at this critical site.
The surprise is that this is only the second
atherosclerosis-prone site to be studied at such an
early stage. There are very few studies of developmental intimal
formation at any site, despite our knowledge that this tissue, the
arterial intima, is the normal tissue, the "soil," in
which atherosclerotic lesions develop.2 The only extensive
studies of intimal formation are in the ductus
arteriosus.3 4 5 Of course, the ductus is not a site that
develops atherosclerosis. The only
atherosclerosis-prone intima reported on before the
present
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