© 1998 American Heart Association, Inc.
Mini Review |
"Stress-Responsive" Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium
From the NHLI Division (P.H.S.) and Division of Biomedical Sciences (A.C.), Imperial College School of Medicine, London, UK.
Correspondence to Peter H. Sugden, D Phil, NHLI Division (Cardiac Medicine), Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK. E-mail p.sugden@ic.ac.uk
Key Words: cardioprotection • mitogen-activated protein kinase • cellular stress • G protein–coupled receptor • hypertrophy/apoptosis
Mitogen-Activated Protein Kinase Cascades: Terminology and Properties
The best-characterized subfamilies of the
mitogen-activated protein kinase (MAPK) superfamily are the
extracellularly responsive kinases (ERKs) and the two
"stress-responsive" MAPK subfamilies, namely, the c-Jun N-terminal
kinases (JNKs) and the p38-MAPKs.1 2 3 4 5 As yet, no
single nomenclature has been determined, and the synonyms currently in
use are summarized in Table 1
. The ERK
cascade is the most thoroughly studied of the MAPK cascades, and it is
activated principally by G protein–coupled receptor (GPCR)
agonists in cardiac myocytes. We have reviewed this topic
recently,6 and we will not discuss it in any
depth here. The regulation of the JNK and p38-MAPK cascades in the
myocardium (Figure 1) forms
the principal subject of this review.
|
|
). The upstream
activators (the MKKKs) of the stress-responsive MKKs have
not been clearly defined but possibly include MEKKs (MAPK or ERK kinase
kinases), This article has been cited by other articles:
 |
|
 |
|
  F. Chen, H. Kan, G. Hobbs, and M. S. Finkel p38 MAP kinase inhibitor reverses stress-induced myocardial dysfunction in vivo J Appl Physiol, April 1, 2009; 106(4): 1132 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Peng, T. Zhang, X. Lu, and Q. Feng JNK1/c-fos inhibits cardiomyocyte TNF-{alpha} expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia Cardiovasc Res, March 1, 2009; 81(4): 733 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mercure, A. Yogi, G. E. Callera, A. B. Aranha, M. Bader, A. J. Ferreira, R. A. S. Santos, T. Walther, R. M. Touyz, and T. L. Reudelhuber Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart Circ. Res., November 21, 2008; 103(11): 1319 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Davis, M. V. Westfall, D. Townsend, M. Blankinship, T. J. Herron, G. Guerrero-Serna, W. Wang, E. Devaney, and J. M. Metzger Designing Heart Performance by Gene Transfer Physiol Rev, October 1, 2008; 88(4): 1567 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Giani, M. M. Gironacci, M. C. Munoz, D. Turyn, and F. P. Dominici Angiotensin-(1-7) has a dual role on growth-promoting signalling pathways in rat heart in vivo by stimulating STAT3 and STAT5a/b phosphorylation and inhibiting angiotensin II-stimulated ERK1/2 and Rho kinase activity Exp Physiol, May 1, 2008; 93(5): 570 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Murphy and C. Steenbergen Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury Physiol Rev, April 1, 2008; 88(2): 581 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Burstein and S. Nattel Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation J. Am. Coll. Cardiol., February 26, 2008; 51(8): 802 - 809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Md. S. Bhuiyan, N. Shioda, and K. Fukunaga Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1606 - E1614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Morisco, C. Marrone, V. Trimarco, S. Crispo, M. G. Monti, J. Sadoshima, and B. Trimarco Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression Cardiovasc Res, December 1, 2007; 76(3): 453 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Zhao, G. Cheng, L. X. Zhang, Y. T. Tseng, and J. F. Padbury Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury Cardiovasc Res, December 1, 2007; 76(3): 473 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-T. Hsu, Y.-C. Hsieh, W. H. Kan, J. G. Chen, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2982 - H2987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. B. Suliman, M. S. Carraway, L. G. Tatro, and C. A. Piantadosi A new activating role for CO in cardiac mitochondrial biogenesis J. Cell Sci., January 15, 2007; 120(2): 299 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Carlson, D. L. Maass, D. J. White, J. Tan, and J. W. Horton Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2779 - H2789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Wall, J. Wei, M. Ly, P. Belmont, J. J. Martindale, D. Tran, J. Sun, W. J. Chen, W. Yu, P. Oeller, et al. Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6 Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2462 - H2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, J. Y. Ma, I. Kerr, S. Chakravarty, S. Dugar, G. Schreiner, and A. A. Protter Selective inhibition of p38{alpha} MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1972 - H1977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clerk and P. H. Sugden Inflame My Heart (by p38-MAPK) Circ. Res., September 1, 2006; 99(5): 455 - 458. [Full Text] [PDF]
|
|
|
|
|
|
O. Tenhunen, J. Rysa, M. Ilves, Y. Soini, H. Ruskoaho, and H. Leskinen Identification of Cell Cycle Regulatory and Inflammatory Genes As Predominant Targets of p38 Mitogen-Activated Protein Kinase in the Heart Circ. Res., September 1, 2006; 99(5): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawano, T. Kubota, Y. Monden, T. Tsutsumi, T. Inoue, N. Kawamura, H. Tsutsui, and K. Sunagawa Blockade of NF-{kappa}B improves cardiac function and survival after myocardial infarction Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1337 - H1344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Babiker, D. Lips, R. Meyer, E. Delvaux, P. Zandberg, B. Janssen, G. van Eys, C. Grohe, and P. A. Doevendans Estrogen Receptor {beta} Protects the Murine Heart Against Left Ventricular Hypertrophy Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1524 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Brown, D. P. Del Re, and M. A. Sussman The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits Circ. Res., March 31, 2006; 98(6): 730 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Iwashima, T. Horio, K. Kamide, H. Rakugi, T. Ogihara, and Y. Kawano Uric Acid, Left Ventricular Mass Index, and Risk of Cardiovascular Disease in Essential Hypertension Hypertension, February 1, 2006; 47(2): 195 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Shao, K. Bhattacharya, E. Hsich, L. Park, B. Walters, U. Germann, Y.-M. Wang, J. Kyriakis, R. Mohanlal, K. Kuida, et al. c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo Circ. Res., January 6, 2006; 98(1): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Kang Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death Toxicol Pathol, January 1, 2006; 34(1): 58 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wohlschlaeger, K. J. Schmitz, C. Schmid, K. W. Schmid, P. Keul, A. Takeda, S. Weis, B. Levkau, and H. A. Baba Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes Cardiovasc Res, December 1, 2005; 68(3): 376 - 386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawano, T. Kubota, Y. Monden, N. Kawamura, H. Tsutsui, A. Takeshita, and K. Sunagawa Blockade of NF-{kappa}B ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II Cardiovasc Res, September 1, 2005; 67(4): 689 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Z. Duan, C. Y. Ivashchenko, M. W. Russell, D. S. Milstone, and R. M. Mortensen Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-{gamma} Both Induce Cardiac Hypertrophy in Mice Circ. Res., August 19, 2005; 97(4): 372 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Poizat, P. L. Puri, Y. Bai, and L. Kedes Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells Mol. Cell. Biol., April 1, 2005; 25(7): 2673 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lou, I. Danelisen, and P. K. Singal Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1925 - H1930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kinugawa, H. Huang, Z. Wang, P. M. Kaminski, M. S. Wolin, and T. H. Hintze A Defect of Neuronal Nitric Oxide Synthase Increases Xanthine Oxidase-Derived Superoxide Anion and Attenuates the Control of Myocardial Oxygen Consumption by Nitric Oxide Derived From Endothelial Nitric Oxide Synthase Circ. Res., February 18, 2005; 96(3): 355 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sanna, O. F. Bueno, Y.-S. Dai, B. J. Wilkins, and J. D. Molkentin Direct and Indirect Interactions between Calcineurin-NFAT and MEK1-Extracellular Signal-Regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth Mol. Cell. Biol., February 1, 2005; 25(3): 865 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Date, S. Mochizuki, A. J. Belanger, M. Yamakawa, Z. Luo, K. A. Vincent, S. H. Cheng, R. J. Gregory, and C. Jiang Expression of constitutively stable hybrid hypoxia-inducible factor-1{alpha} protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury Am J Physiol Cell Physiol, February 1, 2005; 288(2): C314 - C320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Martindale, J. A. Wall, D. M. Martinez-Longoria, P. Aryal, H. A. Rockman, Y. Guo, R. Bolli, and C. C. Glembotski Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects against Myocardial Infarction in Vivo J. Biol. Chem., January 7, 2005; 280(1): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kan, D. Birkle, A. C. Jain, C. Failinger, S. Xie, and M. S. Finkel p38 MAP kinase inhibitor reverses stress-induced cardiac myocyte dysfunction J Appl Physiol, January 1, 2005; 98(1): 77 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Li, Y. Xiao, and L. Zhang Cocaine Induces Apoptosis in Fetal Rat Myocardial Cells through the p38 Mitogen-Activated Protein Kinase and Mitochondrial/Cytochrome c Pathways J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 112 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lu, H. Shimpo, A. Shimamoto, A. J. Chong, C. R. Hampton, D. J. Spring, M. Yada, M. Takao, K. Onoda, I. Yada, et al. Specific inhibition of p38 mitogen-activated protein kinase with FR167653 attenuates vascular proliferation in monocrotaline-induced pulmonary hypertension in rats J. Thorac. Cardiovasc. Surg., December 1, 2004; 128(6): 850 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xie, M. Singh, and K. Singh Osteopontin Modulates Myocardial Hypertrophy in Response to Chronic Pressure Overload in Mice Hypertension, December 1, 2004; 44(6): 826 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Aleshin, Y. Sawa, M. Ono, T. Funatsu, S. Miyagawa, and H. Matsuda Myocardial protective effect of FR167653; a novel cytokine inhibitor in ischemic-reperfused rat heart Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 974 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yada, A. Shimamoto, C. R. Hampton, A. J. Chong, H. Takayama, C. L. Rothnie, D. J. Spring, H. Shimpo, I. Yada, T. H. Pohlman, et al. FR167653 diminishes infarct size in a murine model of myocardial ischemia-reperfusion injury J. Thorac. Cardiovasc. Surg., October 1, 2004; 128(4): 588 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fujimoto, M. Ohno, S. Ayabe, H. Kobayashi, N. Ishizaka, H. Kimura, K.-i. Yoshida, and R. Nagai Carbon Monoxide Protects Against Cardiac Ischemia--Reperfusion Injury In Vivo via MAPK and Akt--eNOS Pathways Arterioscler. Thromb. Vasc. Biol., October 1, 2004; 24(10): 1848 - 1853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Onan, L. Pipolo, E. Yang, R. D. Hannan, and W. G. Thomas Urotensin II Promotes Hypertrophy of Cardiac Myocytes via Mitogen-Activated Protein Kinases Mol. Endocrinol., September 1, 2004; 18(9): 2344 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Inoue, T. Ohkusa, T. Nao, J.-K. Lee, T. Matsumoto, Y. Hisamatsu, T. Satoh, M. Yano, K. Yasui, I. Kodama, et al. Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes: Involvement of mitogen-activated protein kinases and effects of angiotensin ii-receptor antagonist J. Am. Coll. Cardiol., August 18, 2004; 44(4): 914 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sekiguchi, X. Li, M. Coker, M. Flesch, P. M Barger, N. Sivasubramanian, and D. L Mann Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure Cardiovasc Res, August 15, 2004; 63(3): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tongers, B. Fiedler, D. Konig, T. Kempf, G. Klein, J. Heineke, T. Kraft, S. Gambaryan, S. M Lohmann, H. Drexler, et al. Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes Cardiovasc Res, August 15, 2004; 63(3): 545 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu and P. A. Hofmann Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2204 - H2212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Petrich, B. C. Eloff, D. L. Lerner, A. Kovacs, J. E. Saffitz, D. S. Rosenbaum, and Y. Wang Targeted Activation of c-Jun N-terminal Kinase in Vivo Induces Restrictive Cardiomyopathy and Conduction Defects J. Biol. Chem., April 9, 2004; 279(15): 15330 - 15338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kan, Z. Xie, and M. S. Finkel p38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes Am J Physiol Cell Physiol, January 1, 2004; 286(1): C1 - C7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A Gorog, M. Tanno, X. Cao, M. Bellahcene, R. Bassi, A. M.N Kabir, K. Dighe, R. A Quinlan, and M. S Marber Inhibition of p38 MAPK activity fails to attenuate contractile dysfunction in a mouse model of low-flow ischemia Cardiovasc Res, January 1, 2004; 61(1): 123 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kumar, V. Menon, W. R. Ford, A. S. Clanachan, and B. I. Jugdutt Effect of Angiotensin II lype 2 Receptor Blockade on Activation of Mitogen-Activated Protein Kinases after Ischemia-Reperfusion in Isolated Working Rat Hearts Journal of Cardiovascular Pharmacology and Therapeutics, December 1, 2003; 8(4): 285 - 296. [Abstract] [PDF]
|
|
|
|
|
|
M. O. Boluyt, A. M. Loyd, M. H. Roth, M. J. Randall, and E. Y. M. Song Activation of JNK in rat heart by exercise: effect of training Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2639 - H2647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhang, M. Hosaka, Y. Sawada, S. Torii, S. Mizutani, M. Ogata, T. Izumi, and T. Takeuchi Parathyroid Hormone-Related Protein Induces Insulin Expression Through Activation of MAP Kinase-Specific Phosphatase-1 That Dephosphorylates c-Jun NH2-Terminal Kinase in Pancreatic {beta}-Cells Diabetes, November 1, 2003; 52(11): 2720 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Peng, X. Lu, M. Lei, G. W Moe, and Q. Feng Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia Cardiovasc Res, October 1, 2003; 59(4): 893 - 900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gaitanaki, S. Konstantina, S. Chrysa, and I. Beis Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart J. Exp. Biol., August 15, 2003; 206(16): 2759 - 2769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Baba, J. Stypmann, F. Grabellus, P. Kirchhof, A. Sokoll, M. Schafers, A. Takeda, M. J. Wilhelm, H. H. Scheld, N. Takeda, et al. Dynamic regulation of MEK/Erks and Akt/GSK-3{beta} in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism Cardiovasc Res, August 1, 2003; 59(2): 390 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Torsoni, P. M. Fonseca, D. P Crosara-Alberto, and K. G. Franchini Early activation of p160ROCK by pressure overload in rat heart Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1411 - C1419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Huang, S. B. Petkova, A. W. Cohen, B. Bouzahzah, J. Chan, J.-n. Zhou, S. M. Factor, L. M. Weiss, M. Krishnamachary, S. Mukherjee, et al. Activation of Transcription Factors AP-1 and NF-{kappa}B in Murine Chagasic Myocarditis Infect. Immun., May 1, 2003; 71(5): 2859 - 2867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sabri, J. Guo, H. Elouardighi, A. L. Darrow, P. Andrade-Gordon, and S. F. Steinberg Mechanisms of Protease-activated Receptor-4 Actions in Cardiomyocytes. ROLE OF Src TYROSINE KINASE J. Biol. Chem., March 21, 2003; 278(13): 11714 - 11720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Boheler, M. Volkova, C. Morrell, R. Garg, Y. Zhu, K. Margulies, A.-M. Seymour, and E. G. Lakatta Sex- and age-dependent human transcriptome variability: Implications for chronic heart failure PNAS, March 4, 2003; 100(5): 2754 - 2759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Arai, Y. Maruyama, M. Nishida, S. Tanabe, S. Takagahara, T. Kozasa, Y. Mori, T. Nagao, and H. Kurose Differential Requirement of Galpha 12, Galpha 13, Galpha q, and Gbeta gamma for Endothelin-1-Induced c-Jun NH2-Terminal Kinase and Extracellular Signal-Regulated Kinase Activation Mol. Pharmacol., March 1, 2003; 63(3): 478 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Akao, B. O'Rourke, H. Kusuoka, Y. Teshima, S. P. Jones, and E. Marban Differential Actions of Cardioprotective Agents on the Mitochondrial Death Pathway Circ. Res., February 7, 2003; 92(2): 195 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Nadruz Jr, C. B. Kobarg, S. S. Constancio, P. D.C. Corat, and K. G. Franchini Load-Induced Transcriptional Activation of c-jun in Rat Myocardium: Regulation by Myocyte Enhancer Factor 2 Circ. Res., February 7, 2003; 92(2): 243 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, I. A Arenas, S. J Armstrong, and S. T Davidge Estrogen modulation of left ventricular remodeling in the aged heart Cardiovasc Res, February 1, 2003; 57(2): 388 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Ho and J. K. Liao Nonnuclear Actions of Estrogen Arterioscler. Thromb. Vasc. Biol., December 1, 2002; 22(12): 1952 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maruyama, M. Nishida, Y. Sugimoto, S. Tanabe, J. H. Turner, T. Kozasa, T. Wada, T. Nagao, and H. Kurose G{alpha}12/13 Mediates {alpha}1-Adrenergic Receptor-Induced Cardiac Hypertrophy Circ. Res., November 15, 2002; 91(10): 961 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Petrich, X. Gong, D. L. Lerner, X. Wang, J. H. Brown, J. E. Saffitz, and Y. Wang c-Jun N-Terminal Kinase Activation Mediates Downregulation of Connexin43 in Cardiomyocytes Circ. Res., October 4, 2002; 91(7): 640 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. I. Azzam, S. M. de Toledo, D. R. Spitz, and J. B. Little Oxidative Metabolism Modulates Signal Transduction and Micronucleus Formation in Bystander Cells from {alpha}-Particle-irradiated Normal Human Fibroblast Cultures Cancer Res., October 1, 2002; 62(19): 5436 - 5442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. GOUNI-BERTHOLD and A. SACHINIDIS Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells? FASEB J, October 1, 2002; 16(12): 1477 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kapiloff Contributions of Protein Kinase A Anchoring Proteins to Compartmentation of cAMP Signaling in the Heart Mol. Pharmacol., August 1, 2002; 62(2): 193 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Rafiee, Y. Shi, X. Kong, K. A. Pritchard Jr, J. S. Tweddell, S. B. Litwin, K. Mussatto, R. D. Jaquiss, J. Su, and J. E. Baker Activation of Protein Kinases in Chronically Hypoxic Infant Human and Rabbit Hearts: Role in Cardioprotection Circulation, July 9, 2002; 106(2): 239 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Ho and J. K. Liao Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease Mol. Interv., July 1, 2002; 2(4): 219 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Startchik, D. Morabito, U. Lang, and M. F. Rossier Control of Calcium Homeostasis by Angiotensin II in Adrenal Glomerulosa Cells through Activation of p38 MAPK J. Biol. Chem., June 28, 2002; 277(27): 24265 - 24273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Pouzet, J.-B. Lecharny, M. Dehoux, S. Paquin, M. Kitakaze, J. Mantz, and P. Menasche Is there a place for preconditioning during cardiac operations in humans? Ann. Thorac. Surg., March 1, 2002; 73(3): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Luo and M. A. Reidy Activation of Big Mitogen-Activated Protein Kinase-1 Regulates Smooth Muscle Cell Replication Arterioscler. Thromb. Vasc. Biol., March 1, 2002; 22(3): 394 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Antos, T. A. McKinsey, N. Frey, W. Kutschke, J. McAnally, J. M. Shelton, J. A. Richardson, J. A. Hill, and E. N. Olson Activated glycogen synthase-3beta suppresses cardiac hypertrophy in vivo PNAS, January 7, 2002; (2002) 231619298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. MAASS, J.P. KONHILAS, B.L. STAUFFER, and L.A. LEINWAND From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 409 - 416. [Abstract] [PDF]
|
|
|
|
|
|
B.G. PETRICH, P. LIAO, and Y. WANG Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 429 - 438. [Abstract] [PDF]
|
|
|
|
|
|
Y. Takeishi, Q. Huang, J.-i. Abe, W. Che, J.-D. Lee, H. Kawakatsu, B. D Hoit, Bradford.C Berk, and R. A Walsh Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy Cardiovasc Res, January 1, 2002; 53(1): 131 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, K. Shinagawa, L. Pang, T. K. Leung, S. Cardin, Z. Wang, and S. Nattel Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing-Induced Congestive Heart Failure Circulation, November 20, 2001; 104(21): 2608 - 2614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Clerk and P. H. Sugden Untangling the Web: Specific Signaling From PKC Isoforms to MAPK Cascades Circ. Res., November 9, 2001; 89(10): 847 - 849. [Full Text] [PDF]
|
|
|
|
|
|
S. Wei, E. C. Rothstein, L. Fliegel, L. J. Dell'Italia, and P. A. Lucchesi Differential MAP kinase activation and Na+/H+ exchanger phosphorylation by H2O2 in rat cardiac myocytes Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1542 - C1550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Magne, D. Couchie, F. Pecker, and C. Pavoine beta 2-Adrenergic Receptor Agonists Increase Intracellular Free Ca2+ Concentration Cycling in Ventricular Cardiomyocytes through p38 and p42/44 MAPK-mediated Cytosolic Phospholipase A2 Activation J. Biol. Chem., October 19, 2001; 276(43): 39539 - 39548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Eickels, C. Grohe, J. P.M. Cleutjens, B. J. Janssen, H. J.J. Wellens, and P. A. Doevendans 17{beta}-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy Circulation, September 18, 2001; 104(12): 1419 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Behr, S. S. Nerurkar, A. H. Nelson, R. W. Coatney, T. N. Woods, A. Sulpizio, S. Chandra, D. P. Brooks, S. Kumar, J. C. Lee, et al. Hypertensive End-Organ Damage and Premature Mortality Are p38 Mitogen-Activated Protein Kinase-Dependent in a Rat Model of Cardiac Hypertrophy and Dysfunction Circulation, September 11, 2001; 104(11): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Patel, S. F. Nagueh, N. Tsybouleva, M. Abdellatif, S. Lutucuta, H. A. Kopelen, M. A. Quinones, W. A. Zoghbi, M. L. Entman, R. Roberts, et al. Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy Circulation, July 17, 2001; 104(3): 317 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ballard-Croft, D. J. White, D. L. Maass, D. P. Hybki, and J. W. Horton Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-{alpha} Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H1970 - H1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Fischer, S. Ludwig, E. Flory, S. Gambaryan, K. Singh, P. Finn, M. A. Pfeffer, R. A. Kelly, and J. M. Pfeffer Activation of Cardiac c-Jun NH2-Terminal Kinases and p38-Mitogen-Activated Protein Kinases With Abrupt Changes in Hemodynamic Load Hypertension, May 1, 2001; 37(5): 1222 - 1228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Fryer, P. F. Pratt, A. K. Hsu, and G. J. Gross Differential Activation of Extracellular Signal Regulated Kinase Isoforms in Preconditioning and Opioid-Induced Cardioprotection J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 642 - 649. [Abstract] [Full Text]
|
|
|
|
|
|
D. Hreniuk, M. Garay, W. Gaarde, B. P. Monia, R. A. McKay, and C. L. Cioffi Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes Mol. Pharmacol., April 1, 2001; 59(4): 867 - 874. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Vondriska, J. B. Klein, and P. Ping Use of functional proteomics to investigate PKC{epsilon}-mediated cardioprotection: the signaling module hypothesis Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1434 - H1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamashita, J. Kajstura, D. J. Discher, B. J. Wasserlauf, N. H. Bishopric, P. Anversa, and K. A. Webster Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1 Circ. Res., March 30, 2001; 88(6): 609 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Sugden Mechanotransduction in Cardiomyocyte Hypertrophy Circulation, March 13, 2001; 103(10): 1375 - 1377. [Full Text] [PDF]
|
|
|
|
|
|
A. Clerk, F. H. Pham, S. J. Fuller, E. Sahai, K. Aktories, R. Marais, C. Marshall, and P. H. Sugden Regulation of Mitogen-Activated Protein Kinases in Cardiac Myocytes through the Small G Protein Rac1 Mol. Cell. Biol., February 15, 2001; 21(4): 1173 - 1184. [Abstract] [Full Text]
|
|
|
|
|
|
S. Sanada, M. Kitakaze, P. J. Papst, K. Hatanaka, H. Asanuma, T. Aki, Y. Shinozaki, H. Ogita, K. Node, S. Takashima, et al. Role of Phasic Dynamism of p38 Mitogen-Activated Protein Kinase Activation in Ischemic Preconditioning of the Canine Heart Circ. Res., February 2, 2001; 88(2): 175 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schneider, W. Chen, J. Hou, C. Steenbergen, and E. Murphy Inhibition of p38 MAPK {alpha}/{beta} reduces ischemic injury and does not block protective effects of preconditioning Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H499 - H508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Touyz, G. He, M. El Mabrouk, and E. L. Schiffrin p38 MAP Kinase Regulates Vascular Smooth Muscle Cell Collagen Synthesis by Angiotensin II in SHR But Not in WKY Hypertension, February 1, 2001; 37(2): 574 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Kapiloff, N. Jackson, and N. Airhart mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope J. Cell Sci., January 9, 2001; 114(17): 3167 - 3176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Pham, A. E. Harpf, R. S. Keller, H. T. Vu, S.-Y. Shai, J. C. Loftus, and R. S. Ross Striated muscle-specific beta 1D-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2916 - H2926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bolli The Late Phase of Preconditioning Circ. Res., November 24, 2000; 87(11): 972 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. SAURIN, J. L. MARTIN, R. J. HEADS, C. FOLEY, J. W. MOCKRIDGE, M. J. WRIGHT, Y. WANG, and M. S. MARBER The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes FASEB J, November 1, 2000; 14(14): 2237 - 2246. [Abstract] [Full Text]
|
|
|
|
|
|
R. C. X. Li, P. Ping, J. Zhang, W. B. Wead, X. Cao, J. Gao, Y. Zheng, S. Huang, J. Han, and R. Bolli PKCepsilon modulates NF-kappa B and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1679 - H1689. [Abstract] [Full Text] [PDF]
|
|