© 1998 American Heart Association, Inc.
Mini Review |
"Stress-Responsive" Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium
From the NHLI Division (P.H.S.) and Division of Biomedical Sciences (A.C.), Imperial College School of Medicine, London, UK.
Correspondence to Peter H. Sugden, D Phil, NHLI Division (Cardiac Medicine), Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK. E-mail p.sugden@ic.ac.uk
Key Words: cardioprotection • mitogen-activated protein kinase • cellular stress • G protein–coupled receptor • hypertrophy/apoptosis
Mitogen-Activated Protein Kinase Cascades: Terminology and Properties
The best-characterized subfamilies of the
mitogen-activated protein kinase (MAPK) superfamily are the
extracellularly responsive kinases (ERKs) and the two
"stress-responsive" MAPK subfamilies, namely, the c-Jun N-terminal
kinases (JNKs) and the p38-MAPKs.1 2 3 4 5 As yet, no
single nomenclature has been determined, and the synonyms currently in
use are summarized in Table 1
. The ERK
cascade is the most thoroughly studied of the MAPK cascades, and it is
activated principally by G protein–coupled receptor (GPCR)
agonists in cardiac myocytes. We have reviewed this topic
recently,6 and we will not discuss it in any
depth here. The regulation of the JNK and p38-MAPK cascades in the
myocardium (Figure 1) forms
the principal subject of this review.
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). The upstream
activators (the MKKKs) of the stress-responsive MKKs have
not been clearly defined but possibly include MEKKs (MAPK or ERK kinase
kinases), This article has been cited by other articles:
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I. Startchik, D. Morabito, U. Lang, and M. F. Rossier Control of Calcium Homeostasis by Angiotensin II in Adrenal Glomerulosa Cells through Activation of p38 MAPK J. Biol. Chem., June 28, 2002; 277(27): 24265 - 24273. [Abstract] [Full Text] [PDF]
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 B. Pouzet, J.-B. Lecharny, M. Dehoux, S. Paquin, M. Kitakaze, J. Mantz, and P. Menasche Is there a place for preconditioning during cardiac operations in humans? Ann. Thorac. Surg., March 1, 2002; 73(3): 843 - 848. [Abstract] [Full Text] [PDF]
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H. Luo and M. A. Reidy Activation of Big Mitogen-Activated Protein Kinase-1 Regulates Smooth Muscle Cell Replication Arterioscler Thromb Vasc Biol, March 1, 2002; 22(3): 394 - 399. [Abstract] [Full Text] [PDF]
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 A. MAASS, J.P. KONHILAS, B.L. STAUFFER, and L.A. LEINWAND From Sarcomeric Mutations to Heart Disease: Understanding Familial Hypertrophic Cardiomyopathy Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 409 - 416. [Abstract] [PDF]
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B.G. PETRICH, P. LIAO, and Y. WANG Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 429 - 438. [Abstract] [PDF]
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Y. Takeishi, Q. Huang, J.-i. Abe, W. Che, J.-D. Lee, H. Kawakatsu, B. D Hoit, Bradford.C Berk, and R. A Walsh Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy Cardiovasc Res, January 1, 2002; 53(1): 131 - 137. [Abstract] [Full Text] [PDF]
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D. Li, K. Shinagawa, L. Pang, T. K. Leung, S. Cardin, Z. Wang, and S. Nattel Effects of Angiotensin-Converting Enzyme Inhibition on the Development of the Atrial Fibrillation Substrate in Dogs With Ventricular Tachypacing-Induced Congestive Heart Failure Circulation, November 20, 2001; 104(21): 2608 - 2614. [Abstract] [Full Text] [PDF]
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A. Clerk and P. H. Sugden Untangling the Web: Specific Signaling From PKC Isoforms to MAPK Cascades Circ. Res., November 9, 2001; 89(10): 847 - 849. [Full Text] [PDF]
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S. Wei, E. C. Rothstein, L. Fliegel, L. J. Dell'Italia, and P. A. Lucchesi Differential MAP kinase activation and Na+/H+ exchanger phosphorylation by H2O2 in rat cardiac myocytes Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1542 - C1550. [Abstract] [Full Text] [PDF]
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S. Magne, D. Couchie, F. Pecker, and C. Pavoine beta 2-Adrenergic Receptor Agonists Increase Intracellular Free Ca2+ Concentration Cycling in Ventricular Cardiomyocytes through p38 and p42/44 MAPK-mediated Cytosolic Phospholipase A2 Activation J. Biol. Chem., October 19, 2001; 276(43): 39539 - 39548. [Abstract] [Full Text] [PDF]
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M. van Eickels, C. Grohe, J. P.M. Cleutjens, B. J. Janssen, H. J.J. Wellens, and P. A. Doevendans 17{beta}-Estradiol Attenuates the Development of Pressure-Overload Hypertrophy Circulation, September 18, 2001; 104(12): 1419 - 1423. [Abstract] [Full Text] [PDF]
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T. M. Behr, S. S. Nerurkar, A. H. Nelson, R. W. Coatney, T. N. Woods, A. Sulpizio, S. Chandra, D. P. Brooks, S. Kumar, J. C. Lee, et al. Hypertensive End-Organ Damage and Premature Mortality Are p38 Mitogen-Activated Protein Kinase-Dependent in a Rat Model of Cardiac Hypertrophy and Dysfunction Circulation, September 11, 2001; 104(11): 1292 - 1298. [Abstract] [Full Text] [PDF]
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R. Patel, S. F. Nagueh, N. Tsybouleva, M. Abdellatif, S. Lutucuta, H. A. Kopelen, M. A. Quinones, W. A. Zoghbi, M. L. Entman, R. Roberts, et al. Simvastatin Induces Regression of Cardiac Hypertrophy and Fibrosis and Improves Cardiac Function in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy Circulation, July 17, 2001; 104(3): 317 - 324. [Abstract] [Full Text] [PDF]
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C. Ballard-Croft, D. J. White, D. L. Maass, D. P. Hybki, and J. W. Horton Role of p38 mitogen-activated protein kinase in cardiac myocyte secretion of the inflammatory cytokine TNF-{alpha} Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H1970 - H1981. [Abstract] [Full Text] [PDF]
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T. A. Fischer, S. Ludwig, E. Flory, S. Gambaryan, K. Singh, P. Finn, M. A. Pfeffer, R. A. Kelly, and J. M. Pfeffer Activation of Cardiac c-Jun NH2-Terminal Kinases and p38-Mitogen-Activated Protein Kinases With Abrupt Changes in Hemodynamic Load Hypertension, May 1, 2001; 37(5): 1222 - 1228. [Abstract] [Full Text] [PDF]
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R. M. Fryer, P. F. Pratt, A. K. Hsu, and G. J. Gross Differential Activation of Extracellular Signal Regulated Kinase Isoforms in Preconditioning and Opioid-Induced Cardioprotection J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 642 - 649. [Abstract] [Full Text]
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D. Hreniuk, M. Garay, W. Gaarde, B. P. Monia, R. A. McKay, and C. L. Cioffi Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes Mol. Pharmacol., April 1, 2001; 59(4): 867 - 874. [Abstract] [Full Text]
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T. M. Vondriska, J. B. Klein, and P. Ping Use of functional proteomics to investigate PKC{epsilon}-mediated cardioprotection: the signaling module hypothesis Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1434 - H1441. [Abstract] [Full Text] [PDF]
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K. Yamashita, J. Kajstura, D. J. Discher, B. J. Wasserlauf, N. H. Bishopric, P. Anversa, and K. A. Webster Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1 Circ. Res., March 30, 2001; 88(6): 609 - 614. [Abstract] [Full Text] [PDF]
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P. H. Sugden Mechanotransduction in Cardiomyocyte Hypertrophy Circulation, March 13, 2001; 103(10): 1375 - 1377. [Full Text] [PDF]
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A. Clerk, F. H. Pham, S. J. Fuller, E. Sahai, K. Aktories, R. Marais, C. Marshall, and P. H. Sugden Regulation of Mitogen-Activated Protein Kinases in Cardiac Myocytes through the Small G Protein Rac1 Mol. Cell. Biol., February 15, 2001; 21(4): 1173 - 1184. [Abstract] [Full Text]
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S. Sanada, M. Kitakaze, P. J. Papst, K. Hatanaka, H. Asanuma, T. Aki, Y. Shinozaki, H. Ogita, K. Node, S. Takashima, et al. Role of Phasic Dynamism of p38 Mitogen-Activated Protein Kinase Activation in Ischemic Preconditioning of the Canine Heart Circ. Res., February 2, 2001; 88(2): 175 - 180. [Abstract] [Full Text] [PDF]
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S. Schneider, W. Chen, J. Hou, C. Steenbergen, and E. Murphy Inhibition of p38 MAPK {alpha}/{beta} reduces ischemic injury and does not block protective effects of preconditioning Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H499 - H508. [Abstract] [Full Text] [PDF]
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R. M. Touyz, G. He, M. El Mabrouk, and E. L. Schiffrin p38 MAP Kinase Regulates Vascular Smooth Muscle Cell Collagen Synthesis by Angiotensin II in SHR But Not in WKY Hypertension, February 1, 2001; 37(2): 574 - 580. [Abstract] [Full Text] [PDF]
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M. S. Kapiloff, N. Jackson, and N. Airhart mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope J. Cell Sci., January 9, 2001; 114(17): 3167 - 3176. [Abstract] [Full Text] [PDF]
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C. G. Pham, A. E. Harpf, R. S. Keller, H. T. Vu, S.-Y. Shai, J. C. Loftus, and R. S. Ross Striated muscle-specific beta 1D-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2916 - H2926. [Abstract] [Full Text] [PDF]
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R. Bolli The Late Phase of Preconditioning Circ. Res., November 24, 2000; 87(11): 972 - 983. [Abstract] [Full Text] [PDF]
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A. T. SAURIN, J. L. MARTIN, R. J. HEADS, C. FOLEY, J. W. MOCKRIDGE, M. J. WRIGHT, Y. WANG, and M. S. MARBER The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes FASEB J, November 1, 2000; 14(14): 2237 - 2246. [Abstract] [Full Text]
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R. C. X. Li, P. Ping, J. Zhang, W. B. Wead, X. Cao, J. Gao, Y. Zheng, S. Huang, J. Han, and R. Bolli PKCepsilon modulates NF-kappa B and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1679 - H1689. [Abstract] [Full Text] [PDF]
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Y. Izumi, S. Kim, Y. Zhan, M. Namba, H. Yasumoto, and H. Iwao Important Role of Angiotensin II-Mediated c-Jun NH2-Terminal Kinase Activation in Cardiac Hypertrophy in Hypertensive Rats Hypertension, October 1, 2000; 36(4): 511 - 516. [Abstract] [Full Text] [PDF]
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