Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1997;81:355-362

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MacRitchie, A. N.
Right arrow Articles by Shaul, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MacRitchie, A. N.
Right arrow Articles by Shaul, P. W.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ESTRADIOL
(Circulation Research. 1997;81:355-362.)
© 1997 American Heart Association, Inc.

Articles

Estrogen Upregulates Endothelial Nitric Oxide Synthase Gene Expression in Fetal Pulmonary Artery Endothelium

Amy N. MacRitchie, Sandy S. Jun, Zhong Chen, Zohre German, Ivan S. Yuhanna, Todd S. Sherman, , Philip W. Shaul

From the Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas.

Correspondence to Philip W. Shaul, MD, Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-9063. E-mail PSHAUL{at}MEDNET.SWMED.EDU

Abstract NO, produced by endothelial NO synthase (eNOS), is a key mediator of pulmonary vasodilation during cardiopulmonary transition at birth. The capacity for NO production is maximal at term because pulmonary eNOS expression increases during late gestation. Since fetal estrogen levels rise markedly during late gestation and there is indirect evidence that the hormone enhances nonpulmonary NO production in adults, estrogen may upregulate eNOS in fetal pulmonary artery endothelium. Therefore, we studied the direct effects of estrogen on eNOS expression in ovine fetal pulmonary artery endothelial cells (PAECs). Estradiol-17ß caused a 2.5-fold increase in NOS enzymatic activity in PAEC lysates. This effect was evident after 48 hours, and it occurred in response to physiological concentrations of the hormone (10-10 to 10-6 mol/L). The increase in NOS activity was related to an upregulation in eNOS protein expression, and eNOS mRNA abundance was also enhanced. Estrogen receptor antagonism with ICI 182,780 completely inhibited estrogen-mediated eNOS upregulation, indicating that estrogen receptor activation is necessary for this response. In addition, immunocytochemistry revealed that fetal PAECs express estrogen receptor protein. Furthermore, transient transfection assays with a specific estrogen-responsive reporter system have demonstrated that the endothelial estrogen receptor is capable of estrogen-induced transcriptional transactivation. Thus, estrogen upregulates eNOS gene expression in fetal PAECs through the activation of PAEC estrogen receptors. This mechanism may be responsible for pulmonary eNOS upregulation during late gestation, thereby optimizing the capacity for NO-mediated pulmonary vasodilation at birth.


Key Words: endothelium • estrogen • estrogen receptor • nitric oxide synthase • pulmonary circulation




This article has been cited by other articles:


Home page
 HypertensionHome page
D. Xiao, X. Huang, S. Yang, and L. Zhang
Direct Chronic Effect of Steroid Hormones in Attenuating Uterine Arterial Myogenic Tone: Role of Protein Kinase C/Extracellular Signal-Regulated Kinase 1/2
Hypertension, August 1, 2009; 54(2): 352 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Zerr-Fouineau, M. Jourdain, C. Boesch, M. Hecker, C. Bronner, and V. B. Schini-Kerth
Certain Progestins Prevent the Enhancing Effect of 17{beta}-Estradiol on NO-Mediated Inhibition of Platelet Aggregation by Endothelial Cells
Arterioscler Thromb Vasc Biol, April 1, 2009; 29(4): 586 - 593.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. C. McCurnin, R. A. Pierce, B. C. Willis, L. Y. Chang, B. A. Yoder, I. S. Yuhanna, P. L. Ballard, R. I. Clyman, N. Waleh, W. Maniscalco, et al.
Postnatal Estradiol Up-regulates Lung Nitric Oxide Synthases and Improves Lung Function in Bronchopulmonary Dysplasia
Am. J. Respir. Crit. Care Med., March 15, 2009; 179(6): 492 - 500.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Osorio, D. L. Bonilla, A. G. Peniche, P. C. Melby, and B. L. Travi
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production
J. Leukoc. Biol., June 1, 2008; 83(6): 1413 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Cardiovasc DisHome page
P. D. Patel and R. R. Arora
Review: Endothelial dysfunction: A potential tool in gender related cardiovascular disease
Therapeutic Advances in Cardiovascular Disease, April 1, 2008; 2(2): 89 - 100.
[Abstract] [PDF]

Home page
 J. Nutr.Home page
H. Si and D. Liu
Genistein, a Soy Phytoestrogen, Upregulates the Expression of Human Endothelial Nitric Oxide Synthase and Lowers Blood Pressure in Spontaneously Hypertensive Rats
J. Nutr., February 1, 2008; 138(2): 297 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Li, A. Wilson, R. Kuruba, Q. Zhang, X. Gao, F. He, L.-M. Zhang, B. R. Pitt, W. Xie, and S. Li
FXR-mediated regulation of eNOS expression in vascular endothelial cells
Cardiovasc Res, January 1, 2008; 77(1): 169 - 177.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. M. Corbacho, J. P. Eiserich, L. A. Zuniga, G. Valacchi, and A. C. Villablanca
Compromised Aortic Vasoreactivity in Male Estrogen Receptor-{alpha}-Deficient Mice during Acute Lipopolysaccharide-Induced Inflammation
Endocrinology, March 1, 2007; 148(3): 1403 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Christen, I. Cattin, I. Knight, P. G. Winyard, J. W. Blum, and T. H. Elsasser
Plasma S-Nitrosothiol Status in Neonatal Calves: Ontogenetic Associations with Tissue-Specific S-Nitrosylation and Nitric Oxide Synthase
Experimental Biology and Medicine, February 1, 2007; 232(2): 309 - 322.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
Y. Shimasaki, Y. Saito, M. Yoshimura, S. Kamitani, Y. Miyamoto, I. Masuda, M. Nakayama, Y. Mizuno, H. Ogawa, H. Yasue, et al.
The Effects of Long-term Smoking on Endothelial Nitric Oxide Synthase mRNA Expression in Human Platelets as Detected With Real-time Quantitative RT-PCR
Clinical and Applied Thrombosis/Hemostasis, January 1, 2007; 13(1): 43 - 51.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
F. Grassi, X. Fan, J. Rahnert, M. N. Weitzmann, R. Pacifici, M. S. Nanes, and J. Rubin
Bone Re/Modeling Is More Dynamic in the Endothelial Nitric Oxide Synthase(-/-) Mouse
Endocrinology, September 1, 2006; 147(9): 4392 - 4399.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. L. Banka, C. V. Lund, M. T.N. Nguyen, A. J. Pakchoian, B. M. Mueller, and B. P. Eliceiri
Estrogen Induces Lung Metastasis through a Host Compartment-Specific Response.
Cancer Res., April 1, 2006; 66(7): 3667 - 3672.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
O. W.H. van der Heijden, Y. P.G. Essers, G. Fazzi, L. L.H. Peeters, J. G.R. De Mey, and G. J.J.M. van Eys
Uterine Artery Remodeling and Reproductive Performance Are Impaired in Endothelial Nitric Oxide Synthase-Deficient Mice
Biol Reprod, May 1, 2005; 72(5): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. L. Chambliss, L. Simon, I. S. Yuhanna, C. Mineo, and P. W. Shaul
Dissecting the Basis of Nongenomic Activation of Endothelial Nitric Oxide Synthase by Estradiol: Role of ER{alpha} Domains with Known Nuclear Functions
Mol. Endocrinol., February 1, 2005; 19(2): 277 - 289.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Liu, L. L. Homan, and J. S. Dillon
Genistein Acutely Stimulates Nitric Oxide Synthesis in Vascular Endothelial Cells by a Cyclic Adenosine 5'-Monophosphate-Dependent Mechanism
Endocrinology, December 1, 2004; 145(12): 5532 - 5539.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Murata, M. Hori, K. Sakamoto, H. Karaki, and H. Ozaki
Dexamethasone Blocks Hypoxia-induced Endothelial Dysfunction in Organ-cultured Pulmonary Arteries
Am. J. Respir. Crit. Care Med., September 15, 2004; 170(6): 647 - 655.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
F. S. GRAGASIN, E. D. MICHELAKIS, A. HOGAN, R. MOUDGIL, K. HASHIMOTO, X. WU, S. BONNET, A. HAROMY, and S. L. ARCHER
The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels
FASEB J, September 1, 2004; 18(12): 1382 - 1391.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. Koga, K. Hirano, J. Nishimura, H. Nakano, and H. Kanaide
Endothelium-Dependent and Independent Enhancement of Vascular Contractility in the Ovariectomized Rabbit
Reproductive Sciences, July 1, 2004; 11(5): 272 - 279.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
Y. W. Lee, S. Y. Eum, A. Nath, and M. Toborek
Estrogen-mediated protection against HIV Tat protein-induced inflammatory pathways in human vascular endothelial cells
Cardiovasc Res, July 1, 2004; 63(1): 139 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
R. G. Barr, C. C. Wentowski, F. Grodstein, S. C. Somers, M. J. Stampfer, J. Schwartz, F. E. Speizer, and C. A. Camargo Jr
Prospective Study of Postmenopausal Hormone Use and Newly Diagnosed Asthma and Chronic Obstructive Pulmonary Disease
Arch Intern Med, February 23, 2004; 164(4): 379 - 386.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
K. Kakui, H. Itoh, N. Sagawa, S. Yura, D. Korita, M. Takemura, Y. Miyamaoto, Y. Saito, K. Nakao, and S. Fujii
Augmented endothelial nitric oxide synthase (eNOS) protein expression in human pregnant myometrium: possible involvement of eNOS promoter activation by estrogen via both estrogen receptor (ER){alpha} and ER{beta}
Mol. Hum. Reprod., February 1, 2004; 10(2): 115 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Orshal and R. A. Khalil
Gender, sex hormones, and vascular tone
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R233 - R249.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
F. L. Wynne, J. A. Payne, A. E. Cain, J. F. Reckelhoff, and R. A. Khalil
Age-Related Reduction in Estrogen Receptor-Mediated Mechanisms of Vascular Relaxation in Female Spontaneously Hypertensive Rats
Hypertension, February 1, 2004; 43(2): 405 - 412.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Iwakura, C. Luedemann, S. Shastry, A. Hanley, M. Kearney, R. Aikawa, J. M. Isner, T. Asahara, and D. W. Losordo
Estrogen-Mediated, Endothelial Nitric Oxide Synthase-Dependent Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells Contributes to Reendothelialization After Arterial Injury
Circulation, December 23, 2003; 108(25): 3115 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Sumi and L. J. Ignarro
Estrogen-related receptor {alpha}1 up-regulates endothelial nitric oxide synthase expression
PNAS, November 25, 2003; 100(24): 14451 - 14456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Muller-Delp, D. B. Lubahn, K. E. Nichol, B. J. Philips, E. M. Price, E. M. Curran, and M. H. Laughlin
Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor-{alpha}-deficient mice
Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2150 - H2157.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. Widder, T. Pelzer, C. von Poser-Klein, K. Hu, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, and J. Bauersachs
Improvement of Endothelial Dysfunction by Selective Estrogen Receptor-{alpha} Stimulation in Ovariectomized SHR
Hypertension, November 1, 2003; 42(5): 991 - 996.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, W. V. Welshons, M. Sturek, J. W. E. Rush, J. R. Turk, J. A. Taylor, B. M. Judy, K. K. Henderson, and V. K. Ganjam
Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries
J Appl Physiol, July 1, 2003; 95(1): 250 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. E. Ramet, M. Ramet, Q. Lu, M. Nickerson, M. J. Savolainen, A. Malzone, and R. H. Karas
High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life
J. Am. Coll. Cardiol., June 18, 2003; 41(12): 2288 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Afshar, L. L. Gibson, I. S. Yuhanna, T. S. Sherman, J. D. Kerecman, P. H. Grubb, B. A. Yoder, D. C. McCurnin, and P. W. Shaul
Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
Am J Physiol Lung Cell Mol Physiol, May 1, 2003; 284(5): L749 - L758.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. E. Rush, J. R. Turk, and M. H. Laughlin
Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium
Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1378 - H1387.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Harada, K. P. Pavlick, I. N. Hines, D. J. Lefer, J. M. Hoffman, S. Bharwani, R. E. Wolf, and M. B. Grisham
Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: Role of endothelial cell nitric oxide synthase
PNAS, January 21, 2003; 100(2): 739 - 744.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Fleming and R. Busse
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R1 - R12.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. S. Gragasin, Y. Xu, I. A. Arenas, N. Kainth, and S. T. Davidge
Estrogen Reduces Angiotensin II-Induced Nitric Oxide Synthase and NAD(P)H Oxidase Expression in Endothelial Cells
Arterioscler Thromb Vasc Biol, January 1, 2003; 23(1): 38 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. E. Ihionkhan, K. L. Chambliss, L. L. Gibson, L. D. Hahner, M. E. Mendelsohn, and P. W. Shaul
Estrogen Causes Dynamic Alterations in Endothelial Estrogen Receptor Expression
Circ. Res., November 1, 2002; 91(9): 814 - 820.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. L. Chambliss and P. W. Shaul
Estrogen Modulation of Endothelial Nitric Oxide Synthase
Endocr. Rev., October 1, 2002; 23(5): 665 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. L. Mershon, R. S. Baker, and K. E. Clark
Estrogen increases iNOS expression in the ovine coronary artery
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1169 - H1180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Mukundan, T. C. Resta, and N. L. Kanagy
17beta -Estradiol decreases hypoxic induction of erythropoietin gene expression
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R496 - R504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Earley and T. C. Resta
Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression
Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L86 - L93.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Wang and A. A. Abdel-Rahman
Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2309 - H2315.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. L. Chambliss, I. S. Yuhanna, R. G. W. Anderson, M. E. Mendelsohn, and P. W. Shaul
ER{beta} Has Nongenomic Action in Caveolae
Mol. Endocrinol., May 1, 2002; 16(5): 938 - 946.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. C. Villablanca, K. A. Lewis, and J. C. Rutledge
Time- and dose-dependent differential upregulation of three genes by 17beta -estradiol in endothelial cells
J Appl Physiol, March 1, 2002; 92(3): 1064 - 1073.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. S Mikkola and T. B Clarkson
Estrogen replacement therapy, atherosclerosis, and vascular function
Cardiovasc Res, February 15, 2002; 53(3): 605 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
F. A Babiker, L. J De Windt, M. van Eickels, C. Grohe, R. Meyer, and P. A Doevendans
Estrogenic hormone action in the heart: regulatory network and function
Cardiovasc Res, February 15, 2002; 53(3): 709 - 719.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
A. H. WAGNER, M. R. SCHROETER, and M. HECKER
17{beta}-Estradiol inhibition of NADPH oxidase expression in human endothelial cells
FASEB J, October 1, 2001; 15(12): 2121 - 2130.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. A. Parker, S. Afshar, J. P. Kinsella, T. R. Grover, S. Gebb, M. Geraci, P. W. Shaul, C. M. T. Cryer, and S. H. Abman
Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation
Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1005 - H1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. A. BARBERA, V. I. PEINADO, S. SANTOS, J. RAMIREZ, J. ROCA, and R. RODRIGUEZ-ROISIN
Reduced Expression of Endothelial Nitric Oxide Synthase in Pulmonary Arteries of Smokers
Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 709 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. L. Rupnow, T. M. Phernetton, C. E. Shaw, M. L. Modrick, I. M. Bird, and R. R. Magness
Endothelial vasodilator production by uterine and systemic arteries. VII. Estrogen and progesterone effects on eNOS
Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1699 - H1705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. J. Gonzales, B. R. Walker, and N. L. Kanagy
17{beta}-Estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta
Am J Physiol Lung Cell Mol Physiol, March 1, 2001; 280(3): L555 - L564.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, W. G. Schrage, R. M. McAllister, H. A. Garverick, and A. W. Jones
Interaction of gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries
J Appl Physiol, January 1, 2001; 90(1): 216 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. C. Resta, N. L. Kanagy, and B. R. Walker
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression
Am J Physiol Lung Cell Mol Physiol, January 1, 2001; 280(1): L88 - L97.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Najarian, A. M. Marrache, I. Dumont, P. Hardy, M. H. Beauchamp, X. Hou, K. Peri, F. Gobeil Jr, D. R. Varma, and S. Chemtob
Prolonged Hypercapnia-Evoked Cerebral Hyperemia via K+ Channel- and Prostaglandin E2-Dependent Endothelial Nitric Oxide Synthase Induction
Circ. Res., December 8, 2000; 87(12): 1149 - 1156.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Hernandez, J. L. Delgado, J. Diaz, T. Quesada, M. J. G. Teruel, M. C. Llanos, and L. F. Carbonell
17beta -Estradiol prevents oxidative stress and decreases blood pressure in ovariectomized rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1599 - R1605.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Noris, M. Todeschini, S. Zappella, S. Bonazzola, C. Zoja, D. Corna, F. Gaspari, F. Marchetti, S. Aiello, and G. Remuzzi
17beta -Estradiol corrects hemostasis in uremic rats by limiting vascular expression of nitric oxide synthases
Am J Physiol Renal Physiol, October 1, 2000; 279(4): F626 - F635.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. Hardy, I. Dumont, M. Bhattacharya, X. Hou, P. Lachapelle, D. R. Varma, and S. Chemtob
Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy
Cardiovasc Res, August 18, 2000; 47(3): 489 - 509.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. P. Thompson, G. Pinkas, and C. P. Weiner
Chronic 17{beta}-Estradiol Replacement Increases Nitric Oxide-Mediated Vasodilation of Guinea Pig Coronary Microcirculation
Circulation, July 25, 2000; 102(4): 445 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. R. Rosenfeld, R. E. White, T. Roy, and B. E. Cox
Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H319 - H328.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Hayashi, M. Jayachandran, D. Sumi, N. K. Thakur, T. Esaki, E. Muto, H. Kano, Y. Asai, and A. Iguchi
Physiological Concentration of 17{beta}-Estradiol Retards the Progression of Severe Atherosclerosis Induced by a High-Cholesterol Diet Plus Balloon Catheter Injury : Role of NO
Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1613 - 1621.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. A. Salhab, P. W. Shaul, B. E. Cox, and C. R. Rosenfeld
Regulation of types I and III NOS in ovine uterine arteries by daily and acute estrogen exposure
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2134 - H2142.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
P. V. GUILLOT, L. LIU, J. A. KUIVENHOVEN, J. GUAN, R. D. ROSENBERG, and W. C. AIRD
Targeting of human eNOS promoter to the Hprt locus of mice leads to tissue-restricted transgene expression
Physiol Genomics, March 13, 2000; 2(2): 77 - 83.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. German, K. L. Chambliss, M. C. Pace, U. A. Arnet, C. J. Lowenstein, and P. W. Shaul
Molecular Basis of Cell-specific Endothelial Nitric-oxide Synthase Expression in Airway Epithelium
J. Biol. Chem., March 10, 2000; 275(11): 8183 - 8189.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
E. Wight, C. F. Kung, P. Moreau, H. Takase, N. A. Bersinger, and T. F. Luscher
Aging, Serum Estradiol Levels, and Pregnancy Differentially Affect Vascular Reactivity of the Rat Uterine Artery
Reproductive Sciences, March 1, 2000; 7(2): 106 - 113.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. A. Parker, D. Dunbar Ivy, H. L. Galan, T. R. Grover, J. P. Kinsella, and S. H. Abman
Estradiol improves pulmonary hemodynamics and vascular remodeling in perinatal pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L374 - L381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Dumont, P. Hardy, K. G. Peri, X. Hou, S. Molotchnikoff, D. R. Varma, and S. Chemtob
Regulation of endothelial nitric oxide synthase by PGD2 in the developing choroid
Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H60 - H66.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. A. Whitney, Z. German, T. S. Sherman, I. S. Yuhanna, and P. W. Shaul
Cell growth modulates nitric oxide synthase expression in fetal pulmonary artery endothelial cells
Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L131 - L138.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. New, S. J. Duffy, R. W. Harper, and I. T. Meredith
Estrogen improves acetylcholine-induced but not metabolic vasodilation in biological males
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2341 - H2347.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Garcia-Duran, T. de Frutos, J. Diaz-Recasens, G. Garcia-Galvez, A. Jimenez, M. Monton, J. Farre, L. S. de Miguel, F. Gonzalez-Fernandez, M. d. M. Arriero, et al.
Estrogen Stimulates Neuronal Nitric Oxide Synthase Protein Expression in Human Neutrophils
Circ. Res., November 26, 1999; 85(11): 1020 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
I. S. Yuhanna, A. N. MacRitchie, R. L. Lantin-Hermoso, L. B. Wells, and P. W. Shaul
Nitric Oxide (NO) Upregulates NO Synthase Expression in Fetal Intrapulmonary Artery Endothelial Cells
Am. J. Respir. Cell Mol. Biol., November 1, 1999; 21(5): 629 - 636.
[Abstract] [Full Text]

Home page
 StrokeHome page
A. M. McNeill, N. Kim, S. P. Duckles, D. N. Krause, and H. A. Kontos
Chronic Estrogen Treatment Increases Levels of Endothelial Nitric Oxide Synthase Protein in Rat Cerebral Microvessels • Editorial Comment
Stroke, October 1, 1999; 30(10): 2186 - 2190.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Nuedling, S. Kahlert, K. Loebbert, P. A. Doevendans, R. Meyer, H. Vetter, and C. Grohe
17{beta}-Estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo
Cardiovasc Res, August 15, 1999; 43(3): 666 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. Tan, M. V Gurjar, R. V Sharma, and R. C Bhalla
Estrogen receptor-{alpha} gene transfer into bovine aortic endothelial cells induces eNOS gene expression and inhibits cell migration
Cardiovasc Res, August 15, 1999; 43(3): 788 - 797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. C. Pace, K. L. Chambliss, Z. German, I. S. Yuhanna, M. E. Mendelsohn, and P. W. Shaul
Establishment of an immortalized fetal intrapulmonary artery endothelial cell line
Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L106 - L112.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. Zhang, G. A. Massmann, C. P. Mirabile, and J. P. Figueroa
Nonpregnant Sheep Uterine Type I and Type III Nitric Oxide Synthase Expression Is Differentially Regulated by Estrogen
Biol Reprod, May 1, 1999; 60(5): 1198 - 1203.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. A. Kirsch, I. S. Yuhanna, Z. Chen, Z. German, T. S. Sherman, and P. W. Shaul
Estrogen Acutely Stimulates Endothelial Nitric Oxide Synthase in H441 Human Airway Epithelial Cells
Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 658 - 666.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. J. Knot, K. M. Lounsbury, J. E. Brayden, and M. T. Nelson
Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity
Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H961 - H969.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. E. Vagnoni, C. E. Shaw, T. M. Phernetton, B. M. Meglin, I. M. Bird, and R. R. Magness
Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase
Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1845 - H1856.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. R. Magness, T. M. Phernetton, and J. Zheng
Systemic and uterine blood flow distribution during prolonged infusion of 17beta -estradiol
Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H731 - H743.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. G. Geary, D. N. Krause, and S. P. Duckles
Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries
Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H292 - H300.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
B. O Okoye, P. D Losty, M. J Fisher, I. Wilmott, and D. A Lloyd
Effect of dexamethasone on endothelial nitric oxide synthase in experimental congenital diaphragmatic hernia
Arch. Dis. Child. Fetal Neonatal Ed., May 1, 1998; 78(3): 204F - 208.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Wang and A. A. Abdel-Rahman
Estrogen modulation of eNOS activity and its association with caveolin-3 and calmodulin in rat hearts
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2309 - H2315.
[Abstract] [Full Text] [PDF]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1997 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.