© 1997 American Heart Association, Inc.
Articles |
Death by Design
Programmed Cell Death in Cardiovascular Biology and Disease
From the Molecular Cardiology Unit (W.R.M., M.D.S.), the Departments of Medicine (W.R.M.), Cell Biology (M.D.S.), and Molecular Physiology & Biophysics (M.D.S.), and Houston Veterans Affairs Medical Center (W.R.M.), Baylor College of Medicine, Houston, Tex.
Correspondence to Michael D. Schneider, MD, Molecular Cardiology Unit, Baylor College of Medicine, One Baylor Plaza, Room 506C, Houston, TX 77030. E-mail michaels{at}bcm.tmc.edu
Abstract Programmed cell death (apoptosis) is recognized, increasingly, as a contributing cause of cardiac myocyte loss with ischemia/reperfusion injury, myocardial infarction, and long-standing heart failure. Although the exact mechanisms initiating apoptosis in these in vivo settings remain unproven, insights into the molecular circuitry controlling apoptosis more widely suggest the potential to protect mammalian ventricular muscle from apoptosis through one or more of these pathways, by pharmacological means or, conceivably, gene transfer.
Key Words: apoptosis • gene transfer • heart failure • ischemia
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|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 Y. Takada, M. Hashimoto, J. Kasahara, K. Aihara, and K. Fukunaga Cytoprotective Effect of Sodium Orthovanadate on Ischemia/Reperfusion-Induced Injury in the Rat Heart Involves Akt Activation and Inhibition of Fodrin Breakdown and Apoptosis J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1249 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J. M. Hammel, C. A. Caldarone, T. L. Van Natta, L. X. Wang, K. F. Welke, W. Li, S. Niles, E. Barner, T. D. Scholz, D. M. Behrendt, et al. Myocardial apoptosis after cardioplegic arrest in the neonatal lamb J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1268 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hochhauser, S. Kivity, D. Offen, N. Maulik, H. Otani, Y. Barhum, H. Pannet, V. Shneyvays, A. Shainberg, V. Goldshtaub, et al. Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2351 - H2359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Lips, L. J. deWindt, D. J.W. van Kraaij, and P. A. Doevendans Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy Eur. Heart J., May 2, 2003; 24(10): 883 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ogata, M. Takahashi, S. Ueno, K. Takeuchi, T. Okada, H. Mano, S. Ookawara, K. Ozawa, B. C. Berk, U. Ikeda, et al. Antiapoptotic Effect of Endothelin-1 in Rat Cardiomyocytes In Vitro Hypertension, May 1, 2003; 41(5): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 C. Twu, N. Q. Liu, W. Popik, M. Bukrinsky, J. Sayre, J. Roberts, S. Rania, V. Bramhandam, K. P. Roos, W. R. MacLellan, et al. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways PNAS, October 29, 2002; 99(22): 14386 - 14391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
Z.-Q. Zhao and J. Vinten-Johansen Myocardial apoptosis and ischemic preconditioning Cardiovasc Res, August 15, 2002; 55(3): 438 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
 B. ZINGARELLI, P. W. HAKE, Z. YANG, M. O'CONNOR, A. DENENBERG, and H. R. WONG Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-{kappa}B and AP-1 activation and enhances myocardial damage FASEB J, March 1, 2002; 16(3): 327 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 C. R Holleyman and D. F Larson Apoptosis in the ischemic reperfused myocardium Perfusion, December 1, 2001; 16(6): 491 - 502. [Abstract] [PDF]
|
|
|
|
|
|
K. Suzuki, B. Murtuza, R. T. Smolenski, I. A. Sammut, N. Suzuki, Y. Kaneda, and M. H. Yacoub Overexpression of Interleukin-1 Receptor Antagonist Provides Cardioprotection Against Ischemia-Reperfusion Injury Associated With Reduction in Apoptosis Circulation, September 18, 2001; 104 (2009): I-308 - I-313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E Basile-Borgia and V. C Ware Life and death of a cardiac myocyte: principles of cellular biology Perfusion, May 1, 2001; 16(3): 229 - 241. [Abstract] [PDF]
|
|
|
|
|
|
T.-S. Lee and L.-Y. Chau Fas/Fas ligand-mediated death pathway is involved in oxLDL-induced apoptosis in vascular smooth muscle cells Am J Physiol Cell Physiol, March 1, 2001; 280(3): C709 - C718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Andreka, J. Zang, C. Dougherty, T. I. Slepak, K. A. Webster, and N. H. Bishopric Cytoprotection by Jun Kinase During Nitric Oxide-Induced Cardiac Myocyte Apoptosis Circ. Res., February 16, 2001; 88(3): 305 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. He, Y. Xiao, C. A. Casiano, and L. Zhang Role of Mitochondrial Cytochrome c in Cocaine-Induced Apoptosis in Coronary Artery Endothelial Cells J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 896 - 903. [Abstract] [Full Text]
|
|
|
|
|
|
S. W. Rabkin and J. Y Kong Nitroprusside induces cardiomyocyte death: interaction with hydrogen peroxide Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H3089 - H3100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. McDonald, M. N. Grinman, C. M. Carthy, and K. R. Walley Endotoxin infusion in rats induces apoptotic and survival pathways in hearts Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2053 - H2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ding, R. L. Price, E. C. Goldsmith, T. K. Borg, X. Yan, P. S. Douglas, E. O. Weinberg, J. Bartunek, T. Thielen, V. V. Didenko, et al. Left Ventricular Hypertrophy in Ascending Aortic Stenosis Mice : Anoikis and the Progression to Early Failure Circulation, June 20, 2000; 101(24): 2854 - 2862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Schaffer, C. B. Croft, and V. Solodushko Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1948 - H1954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Lefkowitz, H. A. Rockman, and W. J. Koch Catecholamines, Cardiac {beta}-Adrenergic Receptors, and Heart Failure Circulation, April 11, 2000; 101(14): 1634 - 1637. [Full Text] [PDF]
|
|
|
|
|
|
C Berry and A.L Clark Catabolism in chronic heart failure Eur. Heart J., April 1, 2000; 21(7): 521 - 532. [PDF]
|
|
|
|
 |
|
 H.-S. Kim, K.-K. Hwang, J.-W. Seo, S.-Y. Kim, B.-H. Oh, M.-M. Lee, and Y.-B. Park Apoptosis and Regulation of Bax and Bcl-X Proteins During Human Neonatal Vascular Remodeling Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 957 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Stephanou, B. K. Brar, T. M. Scarabelli, A. K. Jonassen, D. M. Yellon, M. S. Marber, R. A. Knight, and D. S. Latchman Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis J. Biol. Chem., March 31, 2000; 275(14): 10002 - 10008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. De Windt, H. W. Lim, T. Taigen, D. Wencker, G. Condorelli, G. W. Dorn II, R. N. Kitsis, and J. D. Molkentin Calcineurin-Mediated Hypertrophy Protects Cardiomyocytes From Apoptosis In Vitro and In Vivo : An Apoptosis-Independent Model of Dilated Heart Failure Circ. Res., February 18, 2000; 86(3): 255 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fujio, T. Nguyen, D. Wencker, R. N. Kitsis, and K. Walsh Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart Circulation, February 15, 2000; 101(6): 660 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. O’Connor, J. S. Schechner, C. Adida, M. Mesri, A. L. Rothermel, F. Li, A. K. Nath, J. S. Pober, and D. C. Altieri Control of Apoptosis during Angiogenesis by Survivin Expression in Endothelial Cells Am. J. Pathol., February 1, 2000; 156(2): 393 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Depre and H. Taegtmeyer Metabolic aspects of programmed cell survival and cell death in the heart Cardiovasc Res, February 1, 2000; 45(3): 538 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rezvani, J.D. Barrans, K.-S. Dai, and C.-C. Liew Apoptosis-related genes expressed in cardiovascular development and disease: an EST approach Cardiovasc Res, February 1, 2000; 45(3): 621 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Q. Zhao, M. Nakamura, N.-P. Wang, J. N. Wilcox, S. Shearer, R. S. Ronson, R. A. Guyton, and J. Vinten-Johansen Reperfusion induces myocardial apoptotic cell death Cardiovasc Res, February 1, 2000; 45(3): 651 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nakamura, N.-P. Wang, Z.-Q. Zhao, J. N Wilcox, V. Thourani, R. A Guyton, and J. Vinten-Johansen Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart Cardiovasc Res, February 1, 2000; 45(3): 661 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Sabbah Apoptotic cell death in heart failure Cardiovasc Res, February 1, 2000; 45(3): 704 - 712. [Full Text] [PDF]
|
|
|
|
|
|
Y. Xiao, J. He, R. D. Gilbert, and L. Zhang Cocaine Induces Apoptosis in Fetal Myocardial Cells through a Mitochondria-Dependent Pathway J. Pharmacol. Exp. Ther., January 1, 2000; 292(1): 8 - 14. [Abstract] [Full Text]
|
|
|
|
|
|
T. Matsui, L. Li, F. del Monte, Y. Fukui, T. F. Franke, R. J. Hajjar, and A. Rosenzweig Adenoviral Gene Transfer of Activated Phosphatidylinositol 3'-Kinase and Akt Inhibits Apoptosis of Hypoxic Cardiomyocytes In Vitro Circulation, December 7, 1999; 100(23): 2373 - 2379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Agnoletti, S. Curello, T. Bachetti, F. Malacarne, G. Gaia, L. Comini, M. Volterrani, P. Bonetti, G. Parrinello, M. Cadei, et al. Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic : Role of Tumor Necrosis Factor-{alpha} Circulation, November 9, 1999; 100(19): 1983 - 1991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.A. Cook and P.A. Poole-Wilson Cardiac myocyte apoptosis Eur. Heart J., November 2, 1999; 20(22): 1619 - 1629. [PDF]
|
|
|
|
|
|
M. Karmazyn, X. T. Gan, R. A Humphreys, H. Yoshida, and K. Kusumoto The Myocardial Na+-H+ Exchange : Structure, Regulation, and Its Role in Heart Disease Circ. Res., October 29, 1999; 85(9): 777 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Arstall, D. B. Sawyer, R. Fukazawa, and R. A. Kelly Cytokine-Mediated Apoptosis in Cardiac Myocytes : The Role of Inducible Nitric Oxide Synthase Induction and Peroxynitrite Generation Circ. Res., October 29, 1999; 85(9): 829 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y. Aw Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine Am. J. Clinical Nutrition, October 1, 1999; 70(4): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-L. Lee, J.-W. Chen, C.-T. Ting, T. Ishiwata, S.-J. Lin, M. Korc, and P. H. Wang Insulin-Like Growth Factor I Improves Cardiovascular Function and Suppresses Apoptosis of Cardiomyocytes in Dilated Cardiomyopathy Endocrinology, October 1, 1999; 140(10): 4831 - 4840. [Abstract] [Full Text]
|
|
|
|
|
|
S. Rohrbach, X. Yan, E. O. Weinberg, F. Hasan, J. Bartunek, M. A. Marchionni, and B. H. Lorell Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis : Differential Expression of erbB2 and erbB4 Receptors Circulation, July 27, 1999; 100(4): 407 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Baghelai, L. J. Graham, A. S. Wechsler, and E. R. Jakoi DELAYED MYOCARDIAL PRECONDITIONING BY {{alpha}}1-ADRENOCEPTORS INVOLVES INHIBITION OF APOPTOSIS J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 980 - 986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.B.J. Burton, M.H. Yacoub, and P.J.R. Barton Cyclin-dependent kinase inhibitor expression in human heart failure. A comparison with fetal development Eur. Heart J., April 2, 1999; 20(8): 604 - 611. [Abstract] [PDF]
|
|
|
|
|
|
P. H. Sugden Signaling in Myocardial Hypertrophy : Life After Calcineurin? Circ. Res., April 2, 1999; 84(6): 633 - 646. [Full Text] [PDF]
|
|
|
|
|
|
A. Shabisgh, N. Tanji, V. D’Agati, M. Burchardt, M. Rubin, E. T. Goluboff, D. Heitjan, A. Kiss, and R. Buttyan Early Effects of Castration on the Vascular System of the Rat Ventral Prostate Gland Endocrinology, April 1, 1999; 140(4): 1920 - 1926. [Abstract] [Full Text]
|
|
|
|
|
|
N. Saadane, L. Alpert, and L. E. Chalifour TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H803 - H814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Ing, J. Zang, V. J. Dzau, K. A. Webster, and N. H. Bishopric Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x Circ. Res., January 22, 1999; 84(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Sharma, D. Chapman, R. Temsah, T. Netticadan, D. P. Brasil, and N. S. Dhalla Prevention of Vascular Apoptosis in Myocardial Infarction by Losartan Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1999; 4(2): 77 - 84. [Abstract] [PDF]
|
|
|
|
|
|
A. Raisanen-Sokolowski, T. Glysing-Jensen, and M. E. Russell Leukocyte-Suppressing Influences of Interleukin (IL)-10 in Cardiac Allografts : Insights from IL-10 Knockout Mice Am. J. Pathol., November 1, 1998; 153(5): 1491 - 1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A Woodcock, S. J Matkovich, and O. Binah Ins(1,4,5)P3 and cardiac dysfunction Cardiovasc Res, November 1, 1998; 40(2): 251 - 256. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Buja and M. L. Entman Modes of Myocardial Cell Injury and Cell Death in Ischemic Heart Disease Circulation, October 6, 1998; 98(14): 1355 - 1357. [Full Text] [PDF]
|
|
|
|
|
|
T. Onodera, T. Tamura, S. Said, S. A. McCune, and A. M. Gerdes Maladaptive Remodeling of Cardiac Myocyte Shape Begins Long Before Failure in Hypertension Hypertension, October 1, 1998; 32(4): 753 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Communal, K. Singh, D. R. Pimentel, and W. S. Colucci Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the ß-Adrenergic Pathway Circulation, September 29, 1998; 98(13): 1329 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lee, G. Morley, Q. Huang, A. Fischer, S. Seiler, J. W. Horner, S. Factor, D. Vaidya, J. Jalife, and G. I. Fishman Conditional lineage ablation to model human diseases PNAS, September 15, 1998; 95(19): 11371 - 11376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, W. Ma, R. Markovich, J.-W. Chen, and P. H. Wang Regulation of Cardiomyocyte Apoptotic Signaling by Insulin-like Growth Factor I Circ. Res., September 7, 1998; 83(5): 516 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kajstura, A. Leri, N. Finato, C. Di Loreto, C. A. Beltrami, and P. Anversa Myocyte proliferation in end-stage cardiac failure in humans PNAS, July 21, 1998; 95(15): 8801 - 8805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A Doevendans, M. J. Daemen, E. D de Muinck, and J. F Smits Cardiovascular phenotyping in mice Cardiovasc Res, July 1, 1998; 39(1): 34 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Haunstetter and S. Izumo Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease Circ. Res., June 15, 1998; 82(11): 1111 - 1129. [Full Text] [PDF]
|
|
|
|
|
|
P. Anversa and J. Kajstura Myocyte Cell Death in the Diseased Heart Circ. Res., June 15, 1998; 82(11): 1231 - 1233. [Full Text] [PDF]
|
|
|
|
|
|
D. Zechner, R. Craig, D. S. Hanford, P. M. McDonough, R. A. Sabbadini, and C. C. Glembotski MKK6 Activates Myocardial Cell NF-kappa B and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner J. Biol. Chem., April 3, 1998; 273(14): 8232 - 8239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, B. Su, V. P. Sah, J. H. Brown, J. Han, and K. R. Chien Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells J. Biol. Chem., March 6, 1998; 273(10): 5423 - 5426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, S. Huang, V. P. Sah, J. Ross Jr., J. H. Brown, J. Han, and K. R. Chien Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family J. Biol. Chem., January 23, 1998; 273(4): 2161 - 2168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wu, W.-L. Lee, Y. Y. Wu, D. Chen, T.-J. Liu, A. Jang, P. M. Sharma, and P. H. Wang Expression of Constitutively Active Phosphatidylinositol 3-Kinase Inhibits Activation of Caspase 3 and Apoptosis of Cardiac Muscle Cells J. Biol. Chem., December 15, 2000; 275(51): 40113 - 40119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Gabai, A. B. Meriin, J. A. Yaglom, J. Y. Wei, D. D. Mosser, and M. Y. Sherman Suppression of Stress Kinase JNK Is Involved in HSP72-mediated Protection of Myogenic Cells from Transient Energy Deprivation. HSP72 ALLEVIATES THE STRESS-INDUCED INHIBITION OF JNK DEPHOSPHORYLATION J. Biol. Chem., November 22, 2000; 275(48): 38088 - 38094. [Abstract] [Full Text] [PDF]
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