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Articles |
Monocyte Chemotactic Protein-1 Increases Collateral and Peripheral Conductance After Femoral Artery Occlusion
From the Department of Experimental Cardiology, Max-Planck-Institute for Physiological and Clinical Research, Bad Nauheim, Germany.
Correspondence to Dr Wulf Ito, MD, Max-Planck-Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Benekestrasse 2, D-61231 Bad Nauheim, Germany. E-mail wito{at}alpha.kerckhoff.mpg.de
Abstract Monocytes are activated during collateral artery growth in vivo, and monocyte chemotactic protein-1 (MCP-1) has been shown to be upregulated by shear stress in vitro. In order to investigate whether MCP-1 enhances collateral growth after femoral artery occlusion, 12 rabbits were randomly assigned to receive either MCP-1, PBS, or no local infusion via osmotic minipump. Seven days after occlusion, isolated hindlimbs were perfused with autologous blood at different pressures, measuring flows at maximal vasodilation via flow probe and radioactive microspheres, as well as peripheral pressures. This allowed the calculation of collateral (thigh) and peripheral (lower limb) conductances from pressure-flow tracings (slope of the curve). Collateral growth on postmortem angiograms was restricted to the thigh and was markedly enhanced with MCP-1 treatment. Both collateral and peripheral conductances were significantly elevated in animals with MCP-1 treatment compared with the control group, reaching values of nonoccluded hindlimbs after only 1 week of occlusion (collateral conductance, 70.6±19.23 versus 25.1±2.59 mL/min per 100 mm Hg; P<.01; peripheral conductance, 119.3±22.37 versus 45.4±6.80 mL/min per 100 mm Hg; P<.05). These results suggest that activation of monocytes plays an important role in collateral growth as well as in capillary sprouting.
Key Words: collateral artery growth • angiogenesis • monocyte • rabbit hindlimb
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N. C. Weber, S. B. Blumenthal, T. Hartung, A. M. Vollmar, and A. K. Kiemer ANP inhibits TNF-{alpha}-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1 J. Leukoc. Biol., November 1, 2003; 74(5): 932 - 941. [Abstract] [Full Text] [PDF]
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 C. Seiler The human coronary collateral circulation Heart, November 1, 2003; 89(11): 1352 - 1357. [Full Text] [PDF]
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 V. Chhokar and A. L. Tucker Angiogenesis: Basic Mechanisms and Clinical Applications Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 253 - 280. [Abstract] [PDF]
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K. Boengler, F. Pipp, B. Fernandez, T. Ziegelhoeffer, W. Schaper, and E. Deindl Arteriogenesis is associated with an induction of the cardiac ankyrin repeat protein (carp) Cardiovasc Res, September 1, 2003; 59(3): 573 - 581. [Abstract] [Full Text] [PDF]
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I. R. Buschmann, H.-J. Busch, G. Mies, and K.-A. Hossmann Therapeutic Induction of Arteriogenesis in Hypoperfused Rat Brain Via Granulocyte-Macrophage Colony-Stimulating Factor Circulation, August 5, 2003; 108(5): 610 - 615. [Abstract] [Full Text] [PDF]
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W. Schaper and D. Scholz Factors Regulating Arteriogenesis Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1143 - 1151. [Abstract] [Full Text] [PDF]
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M. Voskuil, N. van Royen, I. E. Hoefer, R. Seidler, B. D. Guth, C. Bode, W. Schaper, J. J. Piek, and I. R. Buschmann Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1 Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1422 - H1428. [Abstract] [Full Text] [PDF]
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E. Deindl, I. E. Hoefer, B. Fernandez, M. Barancik, M. Heil, M. Strniskova, and W. Schaper Involvement of the Fibroblast Growth Factor System in Adaptive and Chemokine-Induced Arteriogenesis Circ. Res., March 21, 2003; 92(5): 561 - 568. [Abstract] [Full Text] [PDF]
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F. Pipp, M. Heil, K. Issbrucker, T. Ziegelhoeffer, S. Martin, J. van den Heuvel, H. Weich, B. Fernandez, G. Golomb, P. Carmeliet, et al. VEGFR-1-Selective VEGF Homologue PlGF Is Arteriogenic: Evidence for a Monocyte-Mediated Mechanism Circ. Res., March 7, 2003; 92(4): 378 - 385. [Abstract] [Full Text] [PDF]
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J. B. Buckwalter, V. C. Curtis, Z. Valic, S. B. Ruble, and P. S. Clifford Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide J Appl Physiol, March 1, 2003; 94(3): 935 - 940. [Abstract] [Full Text] [PDF]
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N. van Royen, I. Hoefer, M. Bottinger, J. Hua, S. Grundmann, M. Voskuil, C. Bode, W. Schaper, I. Buschmann, and J.J. Piek Local Monocyte Chemoattractant Protein-1 Therapy Increases Collateral Artery Formation in Apolipoprotein E-Deficient Mice but Induces Systemic Monocytic CD11b Expression, Neointimal Formation, and Plaque Progression Circ. Res., February 7, 2003; 92(2): 218 - 225. [Abstract] [Full Text] [PDF]
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N van Royen, I Hoefer, I Buschmann, S Kostin, M Voskuil, C. Bode, W Schaper, and J.J Piek Effects of local MCP-1 protein therapy on the development of the collateral circulation and atherosclerosis in Watanabe hyperlipidemic rabbits Cardiovasc Res, January 1, 2003; 57(1): 178 - 185. [Abstract] [Full Text] [PDF]
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M. Heil, T. Ziegelhoeffer, F. Pipp, S. Kostin, S. Martin, M. Clauss, and W. Schaper Blood monocyte concentration is critical for enhancement of collateral artery growth Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2411 - H2419. [Abstract] [Full Text] [PDF]
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J. Song, M. Qi, S. Kaul, and R. J. Price Stimulation of Arteriogenesis in Skeletal Muscle by Microbubble Destruction With Ultrasound Circulation, September 17, 2002; 106(12): 1550 - 1555. [Abstract] [Full Text] [PDF]
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R. J. Price and S. Kaul Contrast Ultrasound Targeted Drug and Gene Delivery: An Update on a New Therapeutic Modality Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2002; 7(3): 171 - 180. [Abstract] [PDF]
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A. Parenti, L. Brogelli, S. Filippi, S. Donnini, and F. Ledda Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1 Cardiovasc Res, July 1, 2002; 55(1): 201 - 212. [Abstract] [Full Text] [PDF]
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 D. H. Townson, C. L. O'Connor, and J. K. Pru Expression of Monocyte Chemoattractant Protein-1 and Distribution of Immune Cell Populations in the Bovine Corpus Luteum Throughout the Estrous Cycle Biol Reprod, February 1, 2002; 66(2): 361 - 366. [Abstract] [Full Text] [PDF]
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T. O. Nossuli, N. G. Frangogiannis, P. Knuefermann, V. Lakshminarayanan, O. Dewald, A. J. Evans, J. Peschon, D. L. Mann, L. H. Michael, and M. L. Entman Brief murine myocardial I/R induces chemokines in a TNF-alpha -independent manner: role of oxygen radicals Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2549 - H2558. [Abstract] [Full Text] [PDF]
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V. Lindner and T. Maciag The Putative Convergent and Divergent Natures of Angiogenesis and Arteriogenesis Circ. Res., October 26, 2001; 89(9): 747 - 749. [Full Text] [PDF]
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C. Seiler, T. Pohl, K. Wustmann, D. Hutter, P.-A. Nicolet, S. Windecker, F. R. Eberli, and B. Meier Promotion of Collateral Growth by Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease: A Randomized, Double-Blind, Placebo-Controlled Study Circulation, October 23, 2001; 104(17): 2012 - 2017. [Abstract] [Full Text] [PDF]
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V. Lakshminarayanan, M. Lewallen, N. G. Frangogiannis, A. J. Evans, K. E. Wedin, L. H. Michael, and M. L. Entman Reactive Oxygen Intermediates Induce Monocyte Chemotactic Protein-1 in Vascular Endothelium after Brief Ischemia Am. J. Pathol., October 1, 2001; 159(4): 1301 - 1311. [Abstract] [Full Text]
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S. E. Epstein, R. Kornowski, S. Fuchs, and H. F. Dvorak Angiogenesis Therapy : Amidst the Hype, the Neglected Potential for Serious Side Effects Circulation, July 3, 2001; 104(1): 115 - 119. [Full Text] [PDF]
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S. Fuchs, R. Baffour, Y. F. Zhou, M. Shou, A. Pierre, F. O. Tio, N. J. Weissman, M. B. Leon, S. E. Epstein, and R. Kornowski Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1726 - 1732. [Abstract] [Full Text] [PDF]
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M. J. Post, R. Laham, F. W. Sellke, and M. Simons Therapeutic angiogenesis in cardiology using protein formulations Cardiovasc Res, February 16, 2001; 49(3): 522 - 531. [Abstract] [Full Text] [PDF]
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S. E. Epstein, S. Fuchs, Y. F. Zhou, R. Baffour, and R. Kornowski Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards Cardiovasc Res, February 16, 2001; 49(3): 532 - 542. [Abstract] [Full Text] [PDF]
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N. van Royen, J. J. Piek, I. Buschmann, I. Hoefer, M. Voskuil, and W. Schaper Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease Cardiovasc Res, February 16, 2001; 49(3): 543 - 553. [Abstract] [Full Text] [PDF]
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J. Waltenberger Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications Cardiovasc Res, February 16, 2001; 49(3): 554 - 560. [Abstract] [Full Text] [PDF]
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I. E. Hoefer, N. van Royen, I. R. Buschmann, J. J. Piek, and W. Schaper Time course of arteriogenesis following femoral artery occlusion in the rabbit Cardiovasc Res, February 16, 2001; 49(3): 609 - 617. [Abstract] [Full Text] [PDF]
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J. C. Hershey, E. P. Baskin, J. D. Glass, H. A. Hartman, D. B. Gilberto, I. T. Rogers, and J. J. Cook Revascularization in the rabbit hindlimb: dissociation between capillary sprouting and arteriogenesis Cardiovasc Res, February 16, 2001; 49(3): 618 - 625. [Abstract] [Full Text] [PDF]
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