© 1997 American Heart Association, Inc.
Articles |
The Integrin Very Late Antigen-4 Is Expressed in Human Smooth Muscle Cell
Involvement of 
4 and Vascular Cell Adhesion Molecule-1 During Smooth Muscle Cell Differentiation
the Institut National de la Sante et de la Recherche Medicale, Unite 441, Pessac, France.
Correspondence to Cecile Duplaa, INSERM U.441, Avenue du Haut-Leveque, 33600 Pessac, France. E-mail cecile.duplaa@bordeaux.inserm.fr
Vascular cell adhesion molecule-1 (VCAM-1) and its counterreceptor, the integrin very late antigen-4 (VLA-4), have recently been identified in smooth muscle cells during intimal thickening in humans and in newly forming vessels during ontogeny in mice, respectively. We examined the coexpression of VCAM-1 and the 4 integrin subunit in human smooth muscle cells. The expression of VCAM-1 and 4 subunit were studied during development of the aorta. In the 10-week-old human fetal aorta, VCAM-1 and 4 were strongly expressed in smooth muscle cells. Their expression was dramatically reduced within the 24th week of gestation and disappeared in the adult aortic media. However, smooth muscle cells from intimal atherosclerotic thickening of adult aorta reexpressed both VCAM-1 and 4. In a culture model mimicking smooth muscle differentiation, VCAM-1 mRNA and protein and 4 integrin protein were coexpressed with smooth muscle–specific variants of cytoskeletal and contractile proteins, smooth muscle myosin heavy chain, caldesmon heavy chain, and desmin. Treatment with antibodies against VCAM-1 or 4 integrin subunit interfered with the mRNA induction of smooth muscle–specific markers of differentiation. These results in vitro, associated with the transitory expression of VCAM-1 and VLA-4 during vascular ontogeny and the atherosclerosis process, point to a possible role of VCAM-1 and VLA-4 in the induction of smooth muscle differentiation.
Key Words: atherosclerosis • human aortic development • cell-cell interaction • phenotype modulation • smooth muscle marker
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