© 1996 American Heart Association, Inc.
Articles |
Mouse Mutants and Cardiac Development
New Molecular Insights Into Cardiogenesis
From the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada, and the Departments of Molecular and Medical Genetics, and Obstetrics and Gynecology, University of Toronto.
Correspondence to Dr J. Rossant, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto ON M5G 1X5, Canada. E-mail rossant@mshri.on.ca.
Abstract Understanding the genetic control of cardiac development has been greatly assisted by the newly acquired ability to generate targeted mutations in the mouse. A number of mutations in genes that directly or indirectly affect cardiac development have now been reported, and the phenotypes of these mutations have suggested that cardiac development is under complex genetic control. Further analysis of the mouse model system should help elucidate the etiology of human congenital cardiovascular anomalies.
Key Words: cardiogenesis • genetic mutations • mouse
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