© 1995 American Heart Association, Inc.
Articles |
Differential Changes in Cardiac Phospholamban and Sarcoplasmic Reticular Ca2+-ATPase Protein Levels
Effects on Ca2+ Transport and Mechanics in Compensated Pressure-Overload Hypertrophy and Congestive Heart Failure
From the Department of Pharmacology and Cell Biophysics (E.K., E.G.K.) and the Division of Cardiology (N.A.B., R.A.W.), University of Cincinnati (Ohio) College of Medicine.
Correspondence to Richard A. Walsh, Division of Cardiology, University of Cincinnati College of Medicine, 231 Bethesda Ave, Cincinnati, OH 45267-0542.
Abstract The objective of this study was to elucidate the role of the sarcoplasmic reticulum (SR) in the transition from compensated pressure-overload hypertrophy (increased left ventricular [LV] mass, normal LV function, and no pulmonary congestion) to congestive heart failure (increased LV mass, depressed LV function, and pulmonary congestion). To address this issue, the descending thoracic aorta was banded for 4 and 8 weeks in adult guinea pigs, and the changes in isovolumic LV mechanics, SR Ca2+ transport, and SR protein levels were determined and compared with age-matched sham-operated control animals. A subgroup of the 8-week banded animals manifested the congestive heart failure phenotype with diminished developed LV pressure normalized by LV mass, reduced rates of LV pressure development and relaxation, and markedly increased lung weight–to–body weight ratios. The cardiac mechanical and morphometric changes were associated with depressed protein levels of the SR Ca2+-ATPase (85% of the control) and phospholamban (65% of the control) assessed by quantitative immunoblotting. Resultant rates of SR Ca2+ uptake (Vmax) and the affinity of SR Ca2+-ATPase for Ca2+ (EC50) were significantly depressed [32±6 nmol Ca2+ · min-1 · mg-1 and 0.59±0.12 (µmol/L)/L, respectively] compared with the 8-week sham-operated control animals [40±1 nmol Ca2+ · min-1 · mg-1 and 0.40±0.05 (µmol/L)/L, respectively]. We conclude that this model of pressure overload–induced cardiac failure is associated with (1) diminished LV force development, rates of pressure development, and decay; (2) depressed protein expression of the Ca2+-cycling proteins SR Ca2+-ATPase and phospholamban; and (3) decreased Vmax and affinity of the SR Ca2+-ATPase for Ca2+. These findings implicate these Ca2+-cycling proteins in the pathogenesis of congestive heart failure.
Key Words: heart failure • sarcoplasmic reticulum • Ca2+ pump • phospholamban • cardiac mechanics
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
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|
|
|
|
|
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|
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|
|
|
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S. F. Khoury, B. D. Hoit, V. Dave, C. M. Pawloski-Dahm, Y. Shao, M. Gabel, M. Periasamy, and R. A. Walsh Effects of Thyroid Hormone on Left Ventricular Performance and Regulation of Contractile and Ca2+-Cycling Proteins in the Baboon: Implications for the Force-Frequency and Relaxation-Frequency Relationships Circ. Res., October 1, 1996; 79(4): 727 - 735. [Abstract] [Full Text]
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M. Jane Lalli, J. Yong, V. Prasad, K. Hashimoto, D. Plank, G. J. Babu, D. Kirkpatrick, R. A. Walsh, M. Sussman, A. Yatani, et al. Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) 1a Structurally Substitutes for SERCA2a in the Cardiac Sarcoplasmic Reticulum and Increases Cardiac Ca2+ Handling Capacity Circ. Res., July 20, 2001; 89(2): 160 - 167. [Abstract] [Full Text] [PDF]
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