© 1995 American Heart Association, Inc.
Articles |
Voltage-Gated K+ Currents Regulate Resting Membrane Potential and [Ca2+]i in Pulmonary Arterial Myocytes
From the Department of Medicine, Division of Pulmonary and Critical Care Medicine, and the Department of Physiology, University of Maryland School of Medicine, Baltimore.
Correspondence to X.-Jian Yuan, MD, PhD, Pulmonary Division, UMAB Medical School, 10 S Pine St, Suite 800, Baltimore, MD 21201.
Abstract The membrane potential (Em) of pulmonary arterial smooth muscle cells (PASMCs) regulates pulmonary arterial tone by controlling voltage-gated Ca2+ channel activity, which is a major contributor to [Ca2+]i. The resting membrane is mainly permeable to K+; thus, the resting Em is controlled by K+ permeability through sarcolemmal K+ channels. At least three K+ currents, voltage-gated K+ (KV) currents, Ca2+-activated K+ (KCa) currents, and ATP-sensitive (KATP) currents, have been identified in PASMCs. In this study, both patch-clamp and quantitative fluorescent microscopy techniques were used to determine which kind(s) of K+ channels (KV, KCa, and/or KATP) is responsible for controlling Em and [Ca2+]i under resting conditions in rat PASMCs. When the bath solution contained 1.8 mmol/L Ca2+ and the pipette solution included 0.1 mmol/L EGTA, depolarizations (-40 to +80 mV) elicited both KCa and KV currents. Removal of extracellular Ca2+ and increase of intracellular EGTA concentration (to 10 mmol/L) eliminated the Ca2+ influx–dependent KCa current. 4-Aminopyridine (4-AP, 5 to 10 mmol/L) but not charybdotoxin (ChTX, 10 to 20 nmol/L) significantly reduced KV current under these conditions. In current-clamp experiments, 4-AP decreased Em (depolarization) and induced Ca2+-dependent action potentials; this depolarization increased [Ca2+]i in intact PASMCs. Neither ChTX nor the specific blocker of KATP channels, glibenclamide (2 to 10 µmol/L), caused membrane depolarization and the increase in [Ca2+]i. However, pretreatment of PASMCs with ChTX enhanced the 4-AP–induced increase in [Ca2+]i. These results suggest that the 4-AP–sensitive KV currents that are active in the resting state are the major contributors to regulation of Em and thus [Ca2+]i in rat PASMCs.
Key Words: voltage-gated K+ channels • Ca2+-activated K+ channels • ATP-sensitive K+ channels • membrane potential • intracellular Ca2+
This article has been cited by other articles:
 |
|
 |
|
  B. Tang, Y. Li, C. Nagaraj, R. E. Morty, S. Gabor, E. Stacher, R. Voswinckel, N. Weissmann, K. Leithner, H. Olschewski, et al. Endothelin-1 Inhibits Background Two-Pore Domain Channel TASK-1 in Primary Human Pulmonary Artery Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., October 1, 2009; 41(4): 476 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Liang, J. B. Ray, J. Z. He, P. H. Backx, and M. E. Ward Regulation of Proliferation and Membrane Potential by Chloride Currents in Rat Pulmonary Artery Smooth Muscle Cells Hypertension, August 1, 2009; 54(2): 286 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Stirling, M. R. Williams, and A. D. Morielli Dual Roles for RHOA/RHO-Kinase In the Regulated Trafficking of a Voltage-sensitive Potassium Channel Mol. Biol. Cell, June 15, 2009; 20(12): 2991 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Firth, K. H. Yuill, and S. V. Smirnov Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L61 - L70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Shu Zhu, R. E. White, and S. A. Barman Original Research: Role of phosphodiesterases in modulation of BKCa channels in hypertensive pulmonary arterial smooth muscle Therapeutic Advances in Respiratory Disease, June 1, 2008; 2(3): 119 - 127. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Whitman, S. Pisarcik, T. Luke, M. Fallon, J. Wang, J. T. Sylvester, G. L. Semenza, and L. A. Shimoda Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L309 - L318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xu, O. Platoshyn, A. Makino, W. H. Dillmann, K. Akassoglou, C. V. Remillard, and J. X.-J. Yuan Characterization of agonist-induced vasoconstriction in mouse pulmonary artery Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H220 - H228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Ko, E. D. Burg, O. Platoshyn, J. Msefya, A. L. Firth, and J. X.-J. Yuan Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells Am J Physiol Cell Physiol, September 1, 2007; 293(3): C928 - C937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, Y. Yu, E. A Ko, C. V. Remillard, and J. X.-J. Yuan Heterogeneity of hypoxia-mediated decrease in IK(V) and increase in [Ca2+]cyt in pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L402 - L416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhang, H. H. Patel, F. Murray, C. V. Remillard, C. Schach, P. A. Thistlethwaite, Paul. A. Insel, and J. X.-J. Yuan Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1202 - L1210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Remillard, D. D. Tigno, O. Platoshyn, E. D. Burg, E. E. Brevnova, D. Conger, A. Nicholson, B. K. Rana, R. N. Channick, L. J. Rubin, et al. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1837 - C1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Fike, M. R. Kaplowitz, Y. Zhang, and J. A. Madden Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets Am J Physiol Lung Cell Mol Physiol, December 1, 2006; 291(6): L1169 - L1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fantozzi, O. Platoshyn, A. H. Wong, S. Zhang, C. V. Remillard, M. R. Furtado, O. V. Petrauskene, and J. X.-J. Yuan Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L993 - L1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Weir and A. Olschewski Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia Cardiovasc Res, September 1, 2006; 71(4): 630 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bonnet, E. D. Michelakis, C. J. Porter, M. A. Andrade-Navarro, B. Thebaud, S. Bonnet, A. Haromy, G. Harry, R. Moudgil, M. S. McMurtry, et al. An Abnormal Mitochondrial-Hypoxia Inducible Factor-1{alpha}-Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension Circulation, June 6, 2006; 113(22): 2630 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Ross and C. Yallampalli Endothelium-Independent Relaxation by Adrenomedullin in Pregnant Rat Mesenteric Artery: Role of cAMP-Dependent Protein Kinase A and Calcium-Activated Potassium Channels J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1269 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Young, C. Ivester, J. West, M. Carr, and D. M. Rodman BMP signaling controls PASMC KV channel expression in vitro and in vivo Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L841 - L848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cogolludo, L. Moreno, F. Lodi, G. Frazziano, L. Cobeno, J. Tamargo, and F. Perez-Vizcaino Serotonin Inhibits Voltage-Gated K+ Currents in Pulmonary Artery Smooth Muscle Cells: Role of 5-HT2A Receptors, Caveolin-1, and KV1.5 Channel Internalization Circ. Res., April 14, 2006; 98(7): 931 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, E. E. Brevnova, E. D. Burg, Y. Yu, C. V. Remillard, and J. X.-J. Yuan Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells Am J Physiol Cell Physiol, March 1, 2006; 290(3): C907 - C916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cogolludo, L. Moreno, F. Lodi, J. Tamargo, and F. Perez-Vizcaino Postnatal maturational shift from PKC{zeta} and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction Cardiovasc Res, April 1, 2005; 66(1): 84 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. H. Mauban, C. V. Remillard, and J. X.-J. Yuan Hypoxic pulmonary vasoconstriction: role of ion channels J Appl Physiol, January 1, 2005; 98(1): 415 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kunichika, J. W. Landsberg, Y. Yu, H. Kunichika, P. A. Thistlethwaite, L. J. Rubin, and J. X.-J. Yuan Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes Am. J. Respir. Crit. Care Med., November 15, 2004; 170(10): 1101 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Hong, E. K. Weir, D. P. Nelson, and A. Olschewski Subacute Hypoxia Decreases Voltage-Activated Potassium Channel Expression and Function in Pulmonary Artery Myocytes Am. J. Respir. Cell Mol. Biol., September 1, 2004; 31(3): 337 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Brevnova, O. Platoshyn, S. Zhang, and J. X.-J. Yuan Overexpression of human KCNA5 increases IK(V) and enhances apoptosis Am J Physiol Cell Physiol, September 1, 2004; 287(3): C715 - C722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Archer, X.-C. Wu, B. Thebaud, A. Nsair, S. Bonnet, B. Tyrrell, M. S. McMurtry, K. Hashimoto, G. Harry, and E. D. Michelakis Preferential Expression and Function of Voltage-Gated, O2-Sensitive K+ Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction: Ionic Diversity in Smooth Muscle Cells Circ. Res., August 6, 2004; 95(3): 308 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, C. V. Remillard, I. Fantozzi, M. Mandegar, T. T. Sison, S. Zhang, E. Burg, and J. X.-J. Yuan Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L226 - L238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Olschewski, Z. Hong, D. A. Peterson, D. P. Nelson, V. A. Porter, and E. K. Weir Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L15 - L22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cogolludo, L. Moreno, L. Bosca, J. Tamargo, and F. Perez-Vizcaino Thromboxane A2-Induced Inhibition of Voltage-Gated K+ Channels and Pulmonary Vasoconstriction: Role of Protein Kinase C{zeta} Circ. Res., October 3, 2003; 93(7): 656 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bonnet, E. Dumas-de-La-Roque, H. Begueret, R. Marthan, M. Fayon, P. Dos Santos, J.-P. Savineau, and E.-E. Baulieu Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension PNAS, August 5, 2003; 100(16): 9488 - 9493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hampl, J. Bibova, V. Povysilova, and J. Herget Dehydroepiandrosterone sulphate reduces chronic hypoxic pulmonary hypertension in rats Eur. Respir. J., May 1, 2003; 21(5): 862 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Amberg, S. D. Koh, Y. Imaizumi, S. Ohya, and K. M. Sanders A-type potassium currents in smooth muscle Am J Physiol Cell Physiol, March 1, 2003; 284(3): C583 - C595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, M. Sweeney, S. Zhang, O. Platoshyn, J. Landsberg, A. Rothman, and J. X.-J. Yuan PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression Am J Physiol Cell Physiol, February 1, 2003; 284(2): C316 - C330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Olschewski, Z. Hong, B. C. Linden, V. A. Porter, E. K. Weir, and D. N. Cornfield Contribution of the KCa channel to membrane potential and O2 sensitivity is decreased in an ovine PPHN model Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1103 - L1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Olschewski, Z. Hong, D. P. Nelson, and E. K. Weir Graded response of K+ current, membrane potential, and [Ca2+]i to hypoxia in pulmonary arterial smooth muscle Am J Physiol Lung Cell Mol Physiol, November 1, 2002; 283(5): L1143 - L1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Raj and L. Shimoda Oxygen-dependent signaling in pulmonary vascular smooth muscle Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L671 - L677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, S. Zhang, S. S. McDaniel, and J. X.-J. Yuan Cytochrome c activates K+ channels before inducing apoptosis Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1298 - C1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yaghi, S. Mehta, and D. G. McCormack Delayed rectifier potassium channels contribute to the depressed pulmonary artery contractility in pneumonia J Appl Physiol, September 1, 2002; 93(3): 957 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. V. Remillard, W.-M. Zhang, L. A. Shimoda, and J. S. K. Sham Physiological properties and functions of Ca2+ sparks in rat intrapulmonary arterial smooth muscle cells Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L433 - L444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dubuis, M. Gautier, A. Melin, M. Rebocho, C. Girardin, P. Bonnet, and C. Vandier Chronic carbon monoxide enhanced IbTx-sensitive currents in rat resistance pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L120 - L129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Byron and P. A. Lucchesi Signal Transduction of Physiological Concentrations of Vasopressin in A7r5 Vascular Smooth Muscle Cells. A ROLE FOR PYK2 AND TYROSINE PHOSPHORYLATION OF K+ CHANNELS IN THE STIMULATION OF Ca2+ SPIKING J. Biol. Chem., February 22, 2002; 277(9): 7298 - 7307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V Smirnov, R. Beck, P. Tammaro, T. Ishii, and P. I Aaronson Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries J. Physiol., February 1, 2002; 538(3): 867 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krick, O. Platoshyn, M. Sweeney, S. S. McDaniel, S. Zhang, L. J. Rubin, and J. X.-J. Yuan Nitric oxide induces apoptosis by activating K+ channels in pulmonary vascular smooth muscle cells Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H184 - H193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X.-J. Yuan Oxygen-sensitive K+ channel(s): where and what? Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1345 - L1349. [Full Text] [PDF]
|
|
|
|
|
|
S. S. McDaniel, O. Platoshyn, Y. Yu, M. Sweeney, V. A. Miriel, V. A. Golovina, S. Krick, B. R. Lapp, J.-Y. Wang, and J. X.-J. Yuan Anorexic effect of K+ channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells J Appl Physiol, November 1, 2001; 91(5): 2322 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, J. T. Sylvester, G. M. Booth, T. H. Shimoda, S. Meeker, B. J. Undem, and J. S. K. Sham Inhibition of voltage-gated K+ currents by endothelin-1 in human pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1115 - L1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krick, O. Platoshyn, S. S. McDaniel, L. J. Rubin, and J. X.-J. Yuan Augmented K+ currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L887 - L894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, O. Platoshyn, J. Zhang, S. Krick, Y. Zhao, L. J. Rubin, A. Rothman, and J. X.-J. Yuan c-Jun Decreases Voltage-Gated K+ Channel Activity in Pulmonary Artery Smooth Muscle Cells Circulation, September 25, 2001; 104(13): 1557 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Perchenet, L. Hilfiger, J. Mizrahi, and O. Clement-Chomienne Effects of Anorexinogen Agents on Cloned Voltage-Gated K+ Channel hKv1.5 J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 1108 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Belohlavkova, J. Simak, A. Kokesova, O. Hnilickova, and V. Hampl Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels J Appl Physiol, August 1, 2001; 91(2): 755 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Dipp, P. C. G. Nye, and A. M. Evans Hypoxic release of calcium from the sarcoplasmic reticulum of pulmonary artery smooth muscle Am J Physiol Lung Cell Mol Physiol, August 1, 2001; 281(2): L318 - L325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Coppock, J. R. Martens, and M. M. Tamkun Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L1 - L12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bonnet, A. Belus, J.-M. Hyvelin, E. Roux, R. Marthan, and J.-P. Savineau Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L193 - L201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, D. J. Manalo, J. S. K. Sham, G. L. Semenza, and J. T. Sylvester Partial HIF-1{alpha} deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L202 - L208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Reeve, E. Michelakis, D. P. Nelson, E. K. Weir, and S. L. Archer Alterations in a redox oxygen sensing mechanism in chronic hypoxia J Appl Physiol, June 1, 2001; 90(6): 2249 - 2256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Michelakis, E. K. Weir, X. Wu, A. Nsair, R. Waite, K. Hashimoto, L. Puttagunta, H. G. Knaus, and S. L. Archer Potassium channels regulate tone in rat pulmonary veins Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1138 - L1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. McDaniel, O. Platoshyn, J. Wang, Y. Yu, M. Sweeney, S. Krick, L. J. Rubin, and J. X.-J. Yuan Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction Am J Physiol Lung Cell Mol Physiol, May 1, 2001; 280(5): L870 - L880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Cox, K. Folander, and R. Swanson Differential Expression of Voltage-Gated K+ Channel Genes in Arteries From Spontaneously Hypertensive and Wistar-Kyoto Rats Hypertension, May 1, 2001; 37(5): 1315 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krick, O. Platoshyn, M. Sweeney, H. Kim, and J. X.-J. Yuan Activation of K+ channels induces apoptosis in vascular smooth muscle cells Am J Physiol Cell Physiol, April 1, 2001; 280(4): C970 - C979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Rao, L. Li, V. A. Golovina, O. Platoshyn, E. D. Strauch, J. X.-J. Yuan, and J.-Y. Wang Ca2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration Am J Physiol Cell Physiol, April 1, 2001; 280(4): C993 - C1007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, Y. Yu, V. A. Golovina, S. S. McDaniel, S. Krick, L. Li, J.-Y. Wang, Lewis. J. Rubin, and J. X.-J. Yuan Chronic hypoxia decreases KV channel expression and function in pulmonary artery myocytes Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L801 - L812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Golovina, O. Platoshyn, C. L. Bailey, J. Wang, A. Limsuwan, M. Sweeney, L. J. Rubin, and J. X.-J. Yuan Upregulated TRP and enhanced capacitative Ca2+ entry in human pulmonary artery myocytes during proliferation Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H746 - H755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, J. S. K. Sham, T. H. Shimoda, and J. T. Sylvester L-type Ca2+ channels, resting [Ca2+]i, and ET-1-induced responses in chronically hypoxic pulmonary myocytes Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L884 - L894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Platoshyn, V. A. Golovina, C. L. Bailey, A. Limsuwan, S. Krick, M. Juhaszova, J. E. Seiden, L. J. Rubin, and J. X.-J. Yuan Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1540 - C1549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. Thompson, K. Aguan, G. Pinkas, and C. P. Weiner Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1813 - R1820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Doi, D. S. Damron, K. Ogawa, S. Tanaka, M. Horibe, and P. A. Murray K+ channel inhibition, calcium signaling, and vasomotor tone in canine pulmonary artery smooth muscle Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L242 - L251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. K. Sham, B. R. Crenshaw Jr., L.-H. Deng, L. A. Shimoda, and J. T. Sylvester Effects of hypoxia in porcine pulmonary arterial myocytes: roles of KV channel and endothelin-1 Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L262 - L272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Wang, J. Wang, V. A. Golovina, L. Li, O. Platoshyn, and J. X.-J. Yuan Role of K+ channel expression in polyamine-dependent intestinal epithelial cell migration Am J Physiol Cell Physiol, February 1, 2000; 278(2): C303 - C314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Hulme, E. A. Coppock, A. Felipe, J. R. Martens, and M. M. Tamkun Oxygen Sensitivity of Cloned Voltage-Gated K+ Channels Expressed in the Pulmonary Vasculature Circ. Res., September 17, 1999; 85(6): 489 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, J. T. Sylvester, and J. S. K. Sham Chronic hypoxia alters effects of endothelin and angiotensin on K+ currents in pulmonary arterial myocytes Am J Physiol Lung Cell Mol Physiol, September 1, 1999; 277(3): L431 - L439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Cox and S. Petrou Ca2+ influx inhibits voltage-dependent and augments Ca2+-dependent K+ currents in arterial myocytes Am J Physiol Cell Physiol, July 1, 1999; 277(1): C51 - C63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davis and M. A. Hill Signaling Mechanisms Underlying the Vascular Myogenic Response Physiol Rev, April 1, 1999; 79(2): 387 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Reeve, D. P. Nelson, S. L. Archer, and E. K. Weir Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L213 - L219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Bae, M. K. Park, S. H. Lee, W.-K. Ho, and Y. E Earm Contribution of Ca2+-activated K+ channels and non-selective cation channels to membrane potential of pulmonary arterial smooth muscle cells of the rabbit J. Physiol., February 1, 1999; 514(3): 747 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X.-J. Yuan, A. M. Aldinger, M. Juhaszova, J. Wang, J. V. Conte Jr, S. P. Gaine, J. B. Orens, and L. J. Rubin Dysfunctional Voltage-Gated K+ Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension Circulation, October 6, 1998; 98(14): 1400 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Evans, O. N. Osipenko, S. G. Haworth, and A. M. Gurney Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H887 - H899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. S. Lamb and T. J. Barna Chloride ion currents contribute functionally to norepinephrine-induced vascular contraction Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H151 - H160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Taggart and S. Wray Hypoxia and smooth muscle function: key regulatory events during metabolic stress J. Physiol., June 1, 1998; 509(2): 315 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Shimoda, J. T. Sylvester, and J. S. K. Sham Inhibition of voltage-gated K+ current in rat intrapulmonary arterial myocytes by endothelin-1 Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L842 - L853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-J. Yuan, J. Wang, M. Juhaszova, V. A. Golovina, and L. J. Rubin Molecular basis and function of voltage-gated K+ channels in pulmonary arterial smooth muscle cells Am J Physiol Lung Cell Mol Physiol, April 1, 1998; 274(4): L621 - L635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Szentivanyi Jr, V. Berczi, T. Huttl, R. S. Reneman, and E. Monos Venous Myogenic Tone and Its Regulation Through K+ Channels Depends on Chronic Intravascular Pressure Circ. Res., December 19, 1997; 81(6): 988 - 995. [Abstract] [Full Text]
|
|
|
|
|
|
H. Hamada, D. S. Damron, S. J. Hong, D. R. Van Wagoner, and P. A. Murray Phenylephrine-Induced Ca2+ Oscillations in Canine Pulmonary Artery Smooth Muscle Cells Circ. Res., November 19, 1997; 81(5): 812 - 823. [Abstract] [Full Text]
|
|
|
|
|
|
S. V. Smirnov and P. I. Aaronson Modulatory Effects of Arachidonic Acid on the Delayed Rectifier K+ Current in Rat Pulmonary Arterial Myocytes: Structural Aspects and Involvement of Protein Kinase C Circ. Res., July 1, 1996; 79(1): 20 - 31. [Abstract] [Full Text]
|
|
|
|
|
|
S. L. Archer, J. M.C. Huang, H. L. Reeve, V. Hampl, S. Tolarova, E. Michelakis, and E. K. Weir Differential Distribution of Electrophysiologically Distinct Myocytes in Conduit and Resistance Arteries Determines Their Response to Nitric Oxide and Hypoxia Circ. Res., March 1, 1996; 78(3): 431 - 442. [Abstract] [Full Text]
|
|
|
|
|
|
J. N. Rao, O. Platoshyn, L. Li, X. Guo, V. A. Golovina, J. X.-J. Yuan, and J.-Y. Wang Activation of K+ channels and increased migration of differentiated intestinal epithelial cells after wounding Am J Physiol Cell Physiol, April 1, 2002; 282(4): C885 - C898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V Smirnov, R. Beck, P. Tammaro, T. Ishii, and P. I Aaronson Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries J. Physiol., February 1, 2002; 538(3): 867 - 878. [Abstract] [Full Text] [PDF]
|
|