This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schlüter, H. Articles by Zidek, W. Search for Related Content PubMed PubMed Citation Articles by Schlüter, H. Articles by Zidek, W.

(Circulation Research. 1995;76:675-680.)
© 1995 American Heart Association, Inc.

Articles

Coenzyme A Glutathione Disulfide

A Potent Vasoconstrictor Derived From the Adrenal Gland

Hartmut Schlüter, Michael Meissner, Marcus van der Giet, Martin Tepel, Jürgen Bachmann, Isolde Groß, Eckhard Nordhoff, Michael Karas, Claus Spieker, Herbert Witzel, Walter Zidek

From the Medizinische Poliklinik (H.S., M.M., M. van der G., M.T., J.B., I.G., C.S., W.Z.), Institut für Medizinische Physik (E.N., M.K.), and Institut für Biochemie (H.W.), Universität Münster (Germany).

Correspondence to Prof W. Zidek, Medizinische Universität–Poliklinik, Albert-Schweitzer-Str 33, 48129 Münster, Germany.

Abstract The adrenal gland is involved in the regulation of vascular tone by secretion of vasoactive agents such as catecholamines, neuropeptide Y, or endogenous ouabain. A further potent vasoconstrictor is isolated from bovine adrenal glands and is identified by chromatography, mass spectrometry, UV spectroscopy, and enzymatic cleavage as coenzyme A glutathione disulfide (CoASSG). CoASSG is found in chromaffin granules of adrenal glands and is released from adrenal medulla slices by carbachol. At a concentration of 10^-12 mol/L CoASSG increases renal vascular resistance. Intra-aortic injection of 5x10^-10 mol CoASSG increases blood pressure in the intact animal. Besides its vasopressor properties, this substance potentiates the effects of angiotensin II on vascular tone. It is concluded that CoASSG could play a role in blood pressure regulation not only by direct effects but also by modulation of the action of angiotensin II.

Key Words: coenzyme A glutathione disulfide • adrenal gland • vasoactive agents

This article has been cited by other articles:

				J. Jankowski, A. Schroter, M. Tepel, M. van der Giet, N. Stephan, J. Luo, W. Zidek, and H. Schluter Isolation and Characterization of Coenzyme A Glutathione Disulfide as a Parathyroid-Derived Vasoconstrictive Factor Circulation, November 14, 2000; 102(20): 2548 - 2552. [Abstract] [Full Text] [PDF]

				W. Wang and N. Ballatori Endogenous Glutathione Conjugates: Occurrence and Biological Functions Pharmacol. Rev., September 1, 1998; 50(3): 335 - 356. [Abstract] [Full Text] [PDF]