© 1995 American Heart Association, Inc.
Articles |
Preconditioning of Isolated Rat Heart Is Mediated by Protein Kinase C
From the Department of Surgery, University of Colorado Health Sciences Center, Denver.
Abstract Catecholamines have been implicated in the
phenomenon of ischemic preconditioning. We have previously demonstrated
that ischemic preconditioning against postischemic mechanical
dysfunction in the isolated rat heart is mediated by the
1-adrenergic receptor. The purpose of this study was to
delineate the signal transduction of preconditioning distal to the
1-adrenergic receptor. Our results suggest that (1)
transient ischemia and 1-adrenergic receptor–induced
preconditioning is inhibited by protein kinase C (PKC) antagonists, (2)
functional protection against global ischemia/reperfusion injury can be
induced by infusion of diacylglycerol, the second messenger of the
1-adrenergic pathway, and (3) transient ischemia and
1-adrenergic preconditioning are both characterized by
similar translocation of PKC-
to the sarcolemma of myocardium. These
findings suggest that PKC is an effector of preconditioning in the
isolated rat heart.
Key Words: protein kinase C isoforms • 1-adrenergic receptors • ischemic preconditioning • isolated heart • ischemia/reperfusion
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W. Chen, W. Glasgow, E. Murphy, and C. Steenbergen Lipoxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart Am J Physiol Heart Circ Physiol, June 1, 1999; 276(6): H2094 - H2101. [Abstract] [Full Text] [PDF]
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Y. Wang and M. Ashraf Role of Protein Kinase C in Mitochondrial KATP Channel–Mediated Protection Against Ca2+ Overload Injury in Rat Myocardium Circ. Res., May 28, 1999; 84(10): 1156 - 1165. [Abstract] [Full Text] [PDF]
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X. Meng, B. D. Shames, E. J. Pulido, D. R. Meldrum, L. Ao, K. S. Joo, A. H. Harken, and A. Banerjee Adrenergic induction of bimodal myocardial protection: signal transduction and cardiac gene reprogramming Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1525 - R1533. [Abstract] [Full Text] [PDF]
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P. Ping, J. Zhang, X. Cao, R. C. X. Li, D. Kong, X.-L. Tang, Y. Qiu, S. Manchikalapudi, J. A. Auchampach, R. G. Black, et al. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1468 - H1481. [Abstract] [Full Text] [PDF]
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N. L. Bernardo, M. D'Angelo, S. Okubo, A. Joy, and R. C. Kukreja Delayed ischemic preconditioning is mediated by opening of ATP-sensitive potassium channels in the rabbit heart Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1323 - H1330. [Abstract] [Full Text] [PDF]
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P. Ping, H. Takano, J. Zhang, X.-L. Tang, Y. Qiu, R. C. X. Li, S. Banerjee, B. Dawn, Z. Balafonova, and R. Bolli Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits : A Signaling Mechanism for Both Nitric Oxide–Induced and Ischemia-Induced Preconditioning Circ. Res., March 19, 1999; 84(5): 587 - 604. [Abstract] [Full Text] [PDF]
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K. Hu, G.-R. Li, and S. Nattel Adenosine-induced activation of ATP-sensitive K+ channels in excised membrane patches is mediated by PKC Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H488 - H495. [Abstract] [Full Text] [PDF]
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C. J. Albert and D. A. Ford Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H642 - H650. [Abstract] [Full Text] [PDF]
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S. Kawamura, K.-I. Yoshida, T. Miura, Y. Mizukami, and M. Matsuzaki Ischemic preconditioning translocates PKC-delta and -epsilon , which mediate functional protection in isolated rat heart Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2266 - H2271. [Abstract] [Full Text] [PDF]
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N. Maulik, T. Yoshida, Y.-L. Zu, M. Sato, A. Banerjee, and D. K. Das Ischemic preconditioning triggers tyrosine kinase signaling: a potential role for MAPKAP kinase 2 Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1857 - H1864. [Abstract] [Full Text] [PDF]
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S. Perlini, E. P. Khoury, G. R. Norton, E. S. Chung, R. A. Fenton, J. G. Dobson Jr, and T. E. Meyer Adenosine Mediates Sustained Adrenergic Desensitization in the Rat Heart via Activation of Protein Kinase C Circ. Res., October 5, 1998; 83(7): 761 - 771. [Abstract] [Full Text] [PDF]
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B. Z. Simkhovich, K. Przyklenk, and R. A. Kloner Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical review Cardiovasc Res, October 1, 1998; 40(1): 9 - 22. [Abstract] [Full Text] [PDF]
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J. Zhao, O. Renner, L. Wightman, P. H. Sugden, L. Stewart, A. D. Miller, D. S. Latchman, and M. S. Marber The Expression of Constitutively Active Isotypes of Protein Kinase C to Investigate Preconditioning J. Biol. Chem., September 4, 1998; 273(36): 23072 - 23079. [Abstract] [Full Text] [PDF]
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T. F. Rehring, J. I. Shapiro, B. S. Cain, D. R. Meldrum, J. C. Cleveland, A. H. Harken, and A. Banerjee Mechanisms of pH preservation during global ischemia in preconditioned rat heart: roles for PKC and NHE Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H805 - H813. [Abstract] [Full Text] [PDF]
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 A. Clerk, A. Michael, and P. H. Sugden Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein-coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy? J. Cell Biol., July 27, 1998; 142(2): 523 - 535. [Abstract] [Full Text] [PDF]
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T. J. Rohs, K. S. Kilgore, A. J. Georges, and S. F. Bolling Postischemic Function and Protein Kinase C Signal Transduction Ann. Thorac. Surg., June 1, 1998; 65(6): 1680 - 1684. [Abstract] [Full Text] [PDF]
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R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop Circulation, May 19, 1998; 97(18): 1848 - 1867. [Full Text] [PDF]
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L. R. C. Dekker, H. Rademaker, J. T. Vermeulen, T. Opthof, R. Coronel, J. A. E. Spaan, and M. J. Janse Cellular Uncoupling During Ischemia in Hypertrophied and Failing Rabbit Ventricular Myocardium : Effects of Preconditioning Circulation, May 5, 1998; 97(17): 1724 - 1730. [Abstract] [Full Text] [PDF]
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I. Kouchi, T. Murakami, R. Nawada, M. Akao, and S. Sasayama KATP channels are common mediators of ischemic and calcium preconditioning in rabbits Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1106 - H1112. [Abstract] [Full Text] [PDF]
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D. R. Meldrum Tumor necrosis factor in the heart Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R577 - R595. [Abstract] [Full Text] [PDF]
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H. Miyawaki, Y. Wang, and M. Ashraf Oxidant stress with hydrogen peroxide attenuates calcium paradox injury: role of protein kinase C and ATP-sensitive potassium channel Cardiovasc Res, March 1, 1998; 37(3): 691 - 699. [Abstract] [Full Text] [PDF]
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L. R.C Dekker Toward the heart of ischemic preconditioning Cardiovasc Res, January 1, 1998; 37(1): 14 - 20. [Full Text] [PDF]
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J.-F. Bouchard and D. Lamontagne Protection afforded by preconditioning to the diabetic heart against ischaemic injury Cardiovasc Res, January 1, 1998; 37(1): 82 - 90. [Abstract] [Full Text] [PDF]
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M. O. Gray, J. S. Karliner, and D. Mochly-Rosen A Selective epsilon -Protein Kinase C Antagonist Inhibits Protection of Cardiac Myocytes from Hypoxia-induced Cell Death J. Biol. Chem., December 5, 1997; 272(49): 30945 - 30951. [Abstract] [Full Text] [PDF]
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S.-J. O, M. H. Cox, F. A. Crawford Jr., and F. G. Spinale PROTEIN KINASE C ACTIVATION BEFORE CARDIOPLEGIC ARREST: BENEFICIAL EFFECTS ON MYOCYTE CONTRACTILITY J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 651 - 659. [Abstract] [Full Text]
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