Circulation Research, Vol 72, 239-245, Copyright © 1993 by American Heart Association

ARTICLES

Mechanical stress mechanisms and the cell. An endothelial paradigm

PF Davies and SC Tripathi
Department of Pathology, University of Chicago, IL 60637.

There are important physiological and pathological cardiovascular consequences related to endothelial biomechanical properties. The endothelium, however, is not unique in responding to external forces; virtually all cells accommodate or respond to the mechanical environment.

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				G. C. Cheng, P. Libby, A. J. Grodzinsky, and R. T. Lee Induction of DNA Synthesis by a Single Transient Mechanical Stimulus of Human Vascular Smooth Muscle Cells : Role of Fibroblast Growth Factor–2 Circulation, January 1, 1996; 93(1): 99 - 105. [Abstract] [Full Text]

				H. Xie, I. Laher, and J. A. Bevan Intracellular Ca2+ Release in Flow-Induced Contraction of Venous Smooth Muscle Hypertension, December 1, 1995; 26(6): 1051 - 1055. [Abstract] [Full Text]

				H. Tseng, T. E. Peterson, and B. C. Berk Fluid Shear Stress Stimulates Mitogen-Activated Protein Kinase in Endothelial Cells Circ. Res., November 1, 1995; 77(5): 869 - 878. [Abstract] [Full Text]

				A. R. Pries, T. W. Secomb, and P. Gaehtgens Design Principles of Vascular Beds Circ. Res., November 1, 1995; 77(5): 1017 - 1023. [Abstract] [Full Text]

				S. Zhao, A. Suciu, T. Ziegler, J. E. Moore Jr, E. Burki, J.-J. Meister, and H. R. Brunner Synergistic Effects of Fluid Shear Stress and Cyclic Circumferential Stretch on Vascular Endothelial Cell Morphology and Cytoskeleton Arterioscler Thromb Vasc Biol, October 1, 1995; 15(10): 1781 - 1786. [Abstract] [Full Text]

				A. J. Kanai, H. C. Strauss, G. A. Truskey, A. L. Crews, S. Grunfeld, and T. Malinski Shear Stress Induces ATP-Independent Transient Nitric Oxide Release From Vascular Endothelial Cells, Measured Directly With a Porphyrinic Microsensor Circ. Res., August 1, 1995; 77(2): 284 - 293. [Abstract] [Full Text]

				L. Caputo, A. Tedgui, and B. I. Levy Control of Carotid Vasomotor Tone by Local Renin–Angiotensin System in Normotensive and Spontaneously Hypertensive Rats : Role of Endothelium and Flow Circ. Res., August 1, 1995; 77(2): 303 - 309. [Abstract] [Full Text]

				E. Falk, P. K. Shah, and V. Fuster Coronary Plaque Disruption Circulation, August 1, 1995; 92(3): 657 - 671. [Full Text]

				K. J. Williams and I. Tabas The Response-to-Retention Hypothesis of Early Atherogenesis Arterioscler Thromb Vasc Biol, May 1, 1995; 15(5): 551 - 561. [Full Text]