Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1988;62:1041-1048

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Acad, B. A.
Right arrow Articles by Weiss, H. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Acad, B. A.
Right arrow Articles by Weiss, H. R.

Circulation Research, Vol 62, 1041-1048, Copyright © 1988 by American Heart Association

ARTICLES

Improved distribution of regional oxygenation in denervated ischemic dog myocardium

BA Acad, J Joselevitz-Goldman, PM Scholz and HR Weiss
Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854-5635.

The role of the adrenergic nervous system in the response to coronary artery occlusion has been examined using surgical and chemical denervation techniques. Experiments were conducted on four groups of dogs (n = 18): 1) untreated controls; 2) intrapericardial denervation immediately prior to coronary ligation; 3) surgical denervation 2 weeks prior to the experiment; and 4) chemical sympathectomy 5 days prior to the experiment with 6-hydroxydopamine (50 mg/kg). Small artery and vein O2 saturations were obtained microspectrophotometrically and combined with radioactive microsphere blood flow determinations to calculate regional myocardial O2 consumption in open chest dogs. Denervation significantly reduced the preocclusion heart rate from 165 +/- 16 beats/min in the control to 114 +/- 13 in the chronic surgically denervated and to 137 +/- 15 in the chemically sympathectomized groups. After 2 hours of occlusion, the O2 consumption and flow were similar in the nonischemic area except for lower values in the surgically denervated group. Total coronary blood flow and O2 consumption in the occluded regions were not significantly affected by chronic denervation. However, significant elimination of areas with low venous O2 saturation (less than 20%) were found in the ischemic myocardium of the chronically denervated groups as compared with the control or with the acutely denervated dogs. The mean venous O2 saturation was found to be significantly higher in all regions of these two groups as compared with the control. The O2 extraction was also lowered. Thus, chronic denervation reduced microregional heterogeneity of oxygenation in the ischemic myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 RadiologyHome page
G. K. Lund, M. F. Wendland, A. Shimakawa, H. Arheden, F. Ståhlberg, C. B. Higgins, and M. Saeed
Coronary Sinus Flow Measurement by Means of Velocity-encoded Cine MR Imaging: Validation by Using Flow Probes in Dogs
Radiology, November 1, 2000; 217(2): 487 - 493.
[Abstract] [Full Text]

Home page
 CirculationHome page
M. Kitakaze, T. Minamino, K. Node, K. Komamura, Y. Shinozaki, H. Mori, H. Kosaka, M. Inoue, M. Hori, and T. Kamada
Beneficial Effects of Inhibition of Angiotensin-Converting Enzyme on Ischemic Myocardium During Coronary Hypoperfusion in Dogs
Circulation, August 15, 1995; 92(4): 950 - 961.
[Abstract] [Full Text]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1988 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.